Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Aggregation kinetics"”.
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On the reaction coordinate optimality for reversible aggregation kinetics
… atomic cluster transitions, macromolecular aggregation, and protein folding. As a consequence, potential applications related to these transitions span a myriad of scientific areas, from the development of phase change materials in material science to the treatment and prevention of …
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Bayesian Approaches for the Mechanistic Analysis of Protein Aggregation Kinetics
… how mathematical modelling based on chemical kinetics can be used to overcome current challenges in deducing the microscopic mechanism of amyloid formation, in particular in the context of how external perturbations may affect this process. Furthermore, I extended this state-of-the-art …
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An investigation into the behaviour, kinetics & mechanisms involved in the precipitation of a moderately soluble system
… technique, (ii) Determination of growth and aggregation kinetics and (iii) Determination of the induction period.
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Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
… including Alzheimer's disease. Understanding the kinetics of this aggregate build up, how it varies across patients, and how aggregation might be influenced by intracellular pathways is critical for both a deeper knowledge of these disorders as well as identification of potential therapeutic …
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
… to understand and be able to manipulate their aggregation behaviour. In vivo, protein- and peptide-based drugs suffer from different problems, such as short lifetimes and low stability. Lipidation of peptides is widely established as a means of increasing stability in vivo. However, relatively …
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Interfacial behavior of RNA-free MS2 bacteriophage particles
… and RNA removed. Electrophoretic mobility, aggregation kinetics and kinetics of deposition on silica surface were studied for these two nanoparticles. The isoelectric point of MS2 and RNA-free MS2 were found to be 3.4 and 3.2 respectively, found by varying pH at a constant ionic strength. …
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Structural Polymorphism of Alpha-Synuclein in Conditions Resembling the Cellular Environment
… remains elusive. Evidence points towards the aggregation of a small presynaptic protein, alpha-synuclein (aSyn), from its functional disordered form into amyloid fibrils with characteristic β-sheet structure, as being at the centre of PD. However, many unanswered questions remain with regards …
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On the theory of Brownian aggregation in colloidal dispersions
Brownian aggregation kinetics is a topic of interest for colloidal dispersions, macromolecular fluids, nanoparticle self-assembly, and biochemical reactions. The manipulation of colloidal dispersion stability by containing or promoting aggregation rates is manifest in several natural phenomena and …
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Stability and precipitation of diverse nanoparticles
… and water dispersed DNDs is investigated. The aggregation behavior of these two colloidal systems is quite different from that of hydrophilic, water soluble functional ized CNTs (F-CNTs). The values of the Fuchs stability ratio or the critical coagulant concentration are determined …
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An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders.
The misfolding and aggregation of proteins is closely associated with more than fifty human disorders, including Alzheimer's and Parkinson's diseases, all of which are currently incurable and many represent a major threat to human life. The mechanism of protein aggregation is subject to extensive …
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Optimizing the Toehold-Mediated Strand Displacement Reaction on the Nanoparticle Surface by Altering the Surface DNA Density for the Design of a microRNA NanoOptical Sensor
We present a method for modulating the kinetics and thermodynamic properties of aggregation and disassembly processes of DNA-functionalized nanoparticles. Specifically, we examine factors influencing the toehold strand-displacement reaction on nanoparticle surfaces. Gold nanoparticles were …
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Transthyretin Amyloidosis: Proteolytic cleavage accelerates G53A TTR misfolding and aggregation
… was previously demonstrated to promote aggregation as a result of tetrameric structure destabilization. Type A and B fibrils were detected in vivo, suggesting alternative TTR misfolding and aggregation mechanisms. The main component of the fibrils was the residue 49-127 fragment. In the …
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Effects of glycosylation on the structure and fibrillization of prion protein fragments
… in high yields. Comparison of the structure, aggregation kinetics, fibril formation capabilities and redox susceptibility of Cys 179 has shown that the N-linked glycan (at Asn 181) significantly reduces the rate of fibrillization by promoting intermolecular disulfide formation via Cys 179. …
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Assessing the impact of N-terminal acetylation on the aggregation of alpha-synuclein and its disease-related mutants
… disease is associated with the aberrant aggregation of α-synuclein within neurons. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role. Since α-synuclein is constitutively N-terminally acetylated, we …
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Modelling Early Events In Amyloid Aggregation
… this. By contrast, the initiation of the aggregation reaction has been comparatively understudied, despite the involvement of oligomeric intermediates that are considered to be the key pathogenic agents in many amyloidogenic diseases. This is due in large part to the key quantities …
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Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
… sections of the thesis focus on AD-linked Aβ42 aggregation kinetics and mechanisms on lipid membranes. By applying chemical kinetics approach, I found that rates of distinct microscopic Aβ42 aggregation steps depend on the composition of cell membrane mimetic liposomes. Furthermore, the results …
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Protein Biophysics in Hollow-Core Photonic Crystal Fibres: Label-Free Monitoring of Biomolecules in Optofluidic Waveguides
… interactions that determine their aggregation mechanisms. In this PhD dissertation, we study the use of hollow-core photonic crystal fibre (HC-PCF), a class of optofluidic waveguides, to optically detect and monitor proteins in microfluidic environments without labels. Within this …
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Engineering Superparamagnetic Iron Oxide Nanoparticles for Environmental Applications
… to transfer efficiency (into the aqueous phase), aggregation kinetics (varying ionic types/strengths), and long-term aqueous stabilities. Further, for IONPs with oleic acid bilayer coatings, before and after surface (oxidative) aging, extensive evaluation of surface/collector deposition and …
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Understanding protein misfolding diseases through the development of biophysical methods
… is associated with the aberrant misfolding and aggregation of the Aβ peptide into amyloid plaques in the brains of affected individuals. Despite substantial progress in the understanding of the mechanism of aggregation of Aβ, the variety of ways in which imbalances in brain metabolism can …
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Aggregation Behavior of Chiral Single-Walled Carbon Nanotubes and their Transport in Landfill Conditions
… effects of variation in electronic structure on aggregation of chiral single-walled carbon nanotubes (SWNTs) and their transport in landfill conditions. This study involves four key tasks: functionalization of chirally separated SWNTs, aggregation kinetics of covalently and non-covalently …
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