Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Aggregation inhibition"”.
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Isolation, engineering, and characterization of intracellular antibodies specific for the huntingtin protein
… and adopt a conformation which is prone to aggregation. Intracellular antibodies (intrabodies) against htt have been shown to reduce htt aggregation by binding to the htt fragment and inactivating it or preventing its misfolding. Intrabodies may therefore be a useful gene therapy approach to …
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The Role of Reactive Oxygen Species in Crotalus atrox Venom-induced Cell Death
… effects such as vascular hemorrhage, platelet aggregation inhibition, and the activation of inflammatory mediators. However, hemorrhagic snake venom also causes a loss of cellular adhesion to extracellular matrix components resulting in massive local tissue damage. To better understand the …
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Targeting Tau Aggregation for the Diagnosis and Treatment of Alzheimer’s Disease
The aggregation of tau protein in the brain is a defining pathological characteristic of several diseases, known as tauopathies, the most common of which is Alzheimer’s disease. Because the temporal and spatial progression of tau lesions correlates with neurodegeneration and cognitive decline, they …
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Model-Based Measures Of Interrater Agreement
… has demonstrated both AChE inhibition and M2 receptor antagonism at submicromolar concentrations in in vitro assays, which provides a prototypical compound for a new class of MTDLs for the potential therapy of AD. In the present study, JWS was resynthesized utilizing …
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Drug discovery for misfolding diseases using structure-based iterative learning
… Numerous clinical trials targeting α-synuclein aggregation, a process implicated in Parkinson’s disease and other synucleinopathies, have failed, at least in part due to the challenges in identifying potent compounds in preclinical investigations. In Chapter 2, I describe machine learning …