Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Aggregate degradation"”.
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Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
The accumulation of intraneuronal aggregated tau protein underlies many common neurodegenerative diseases and is a key target in therapeutic development. Whilst promising in pre-clinical models, tau targeting antibodies have performed poorly in clinical trials, potentially due to low target …
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Advanced image analysis and techniques for degradation characterization of aggregates
… or shape properties of virgin and recycled aggregate sources are known to affect pavement and railroad track mechanistic behavior and performance significantly in terms of strength, modulus and permanent deformation. Under repeated traffic loading aggregate particles used in construction of …