Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Ageing and Disease"”.
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Psychophysical aspects of clinical perimetry: studies in ageing and disease
… CS change with age across the VF? Are static and kinetic perimetry results actually the same? Can factors causing increased measurement variability in perimetry be systematically quantified and eliminated? Thus, the aim of this thesis is to address these specific limitations of clinical …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… Yet, through developmental growth to adulthood and into ageing, the mammalian heart undergoes extensive physiological, morphological and biochemical remodelling. Pivotal to the age-associated alterations in cardiac phenotype is a decline in the proliferative capacity of cardiac myocytes (CMs), …
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How to Mend a Broken Mitochondrial Genome: Mitochondrial Recombination And Its Applications
Animal mitochondria produce cellular energy and rely on genes encoded within their own genome (mtDNA) in addition to those in the nucleus. mtDNA mutations are linked to mitochondrial and age-related diseases. Therefore, safeguarding mechanisms are crucial to limit mtDNA mutations and curtail ageing …
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Natural variation in the human plasma lipidome signature using mass spectrometry: relevance to healthy ageing
Population ageing and the associated increase in neurodegenerative diseases has made brain health an important research priority. Lipidomics, a subfield of omics, involves characterisation and quantification of total lipids in biological systems. Since brain lipids influence protein function and …
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The in vivo effects of copper, manganese and mercury mixtures on the heart, lung and brain and the coagulation system in the Sprague-Dawley rat model
… contributing to cardiovascular, respiratory and neurodegenerative diseases. There is some data on the effects of metal exposure and potential toxic effects, but more information is needed regarding copper, manganese and mercury exposure, especially as part of metal mixtures. The aim of this …
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Age-dependent regulation of hippocampal excitatory synaptic transmission by leptin
… of hippocampal synaptic function (Irving and Harvey, 2014). Previous studies demonstrate that leptin can regulate hippocampal excitatory synaptic transmission in an age-dependent manner at Schaffer collateral (SC)-CA1 synapses (Moult and Harvey, 2011). In addition, recent evidence …
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Identification of Novel Drivers of Haematopoietic Stem Cell Fate Using Low Cell Number Proteomics and Single Cell Profiling
The abrogation and de-regulation of cellular decisions in adult haematopoietic stem cells (HSCs) have been widely recognised as key contributing factors in ageing and disease. In particular, acquired mutations altering HSC self-renewal contribute to the formation of pre-leukaemic disorders, such as …
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Blood Pressure, Arterial Stiffness and Cardiovascular Risk Prediction
… need to improve current cardiovascular (CV) disease risk prediction algorithms, allowing better stratification models for disease prevention and, ultimately, a personalised medicine approach. This is particularly important for ‘moderate risk’ individuals, where relatively few people will …
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Signal Transduction in Skeletal Muscle Mediating Responses to Phenotype Altering Signals
Skeletal muscle phenotype, size and function respond to exercise, disease and ageing. The aim of this thesis was to investigate the signal transduction pathways responsible for selected skeletal muscle phenotype and size changes. Myostatin, recently identified as a negative regulator of muscle mass …
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Lattice Boltzmann method for integrating the Bloch equation in muscle fibers and microvessels
Reduction in lean body mass and increase in fat mass lead to decline in strength and physical function and are therefore largely associated with aging and obesity. Recent research has demonstrated that Magnetic Resonance Imaging (MRI) can measure the local properties of directional water diffusion …