Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Age-Related Macular Degeneration"”.
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Advanced imaging biomarkers in age-related macular degeneration
Η ηλικιακή εκφύλιση της ωχράς κηλίδας, είναι μία κύρια αιτία σημαντικής μείωσης της όρασης παγκοσμίως, ενώ η επίπτωση της εκτιμάται ότι θα αυξηθεί σημαντικά. Η αναγνώριση πρώιμων βιοδεικτών που θα σημάνουν την αυξημένη πιθανότητα μετάπτωσης από πρώιμα σε πιο προχωρημένα στάδια της νόσου, που …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… in rat that mimics pathologic conditions such as age-related macular degeneration (AMD) using amyloid-beta (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics …
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Effects of combination therapies on age-related macular degeneration
Age-related macular degeneration (AMD) is the most common cause of vision loss in America for people over the age of 60. Due to damage to the retina, symptoms normally include blurred central vision, difficulty reading, and seeing shadows. While there is no cure for the disease, there are …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… wellbeing. Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments responsible for blindness worldwide. There is currently no effective treatment available to cure AMD completely. Anti-VEGF therapy is currently considered the treatment of choice. …
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Rare genetic variants in patients with age-related macular degeneration
Contains fulltext : 148918.pdf (Publisher’s version ) (Open Access)
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Visual field and structural alterations in age-related macular degeneration
… of patients with varying degrees of agerelated macular degeneration (AMD). The relationships between structure and function were investigated for both standard and short-wavelength automated perimetry (SWAP). Factors known to influence the measure of visual field progression were …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on a global scale as one of the major back-of-the-eye disorders being responsible for blindness in elderly patients over 60 years. As there is no efficacious cure to completely prevent AMD, the …
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Investigating the genetic and molecular basis of age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors contribute to the development of AMD. An AMD-risk locus on chromosome 10q26 spans two genes, ARMS2 and HTRA1, …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. There is currently no cure for AMD although several risk factors have been implicated in the pathogenesis and progression of the disease. These include oxidative stress, inflammation and vascular changes. …
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Improving face perception and quality of life in age-related macular degeneration
… social interactions and good quality of life. Age-related macular degeneration (AMD) is a progressive eye condition that damages central vision required to see faces clearly. This thesis aims to investigate potential means to improve quality of life in AMD, via a two-pronged approach. The first …
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Improving face perception and quality of life in age-related macular degeneration
… social interactions and good quality of life. Age-related macular degeneration (AMD) is a progressive eye condition that damages central vision required to see faces clearly. This thesis aims to investigate potential means to improve quality of life in AMD, via a two-pronged approach. The first …
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Potential of endothelial progenitors to reverse choroidal atrophy during age related macular degeneration
… their ability to integrate with and repair damaged vasculature. Overall this could improve the probability of a successful procedure. This approach of cell functional improvement may bring us closer to developing a viable, cell based therapy to prevent the vision loss caused by dry AMD. The …
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Genetics of age-related macular degeneration and Stargardt disease in South African populations
… points of particular note have emerged regarding Macular Degenerations (MD) : (i) that more than 58% of juvenile MD, notably Stargardt Disease (STGD) , in Caucasian populations may have the underlying causative genetic defect identified , while only 1 1 % of the similar phenotype in indigenous …
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Drug Loaded Multifunctional Microparticles for Anti-VEGF Therapy of Exudative Age-related Macular Degeneration
<p>Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness in people over age 65 in industrialized nations. The exudative AMD accounts for only 10% to 20% of AMD cases, but causes 80 to 90% of cases with severe vision loss related to AMD. The current intravitreal …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
Age-related macular degeneration (AMD), typically manifesting as a loss of central vision in elderly persons, is a leading cause of blindness in highly developed nations. AMD is a multifactorial disease associated with aging, oxidative stress, complement dysregulation, dsRNA toxicity, among many …
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DOSE RANGING STUDY OF LUTEIN SUPPLEMENTATION IN ELDERLY WITH AND WITHOUT AGE RELATED MACULAR DEGENERATION
Age-related macular degeneration (AMD) is the leading cause of blindness among people over the age of 65. Epidemiological studies have indicated that people with a high intake of two dietary carotenoids, lutein and zeaxanthin that accumulate in the human macula, are at a reduced risk of AMD. …
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Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration
PURPOSE: Age-related macular degeneration (ARMD) is a leading cause of irreversible blindness in the industrialized world. Studies suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the …
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Structure-function relationships in Age-related macular degeneration in an era of multi-modal retinal imaging
Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the western world. Multimodal imaging has contributed a lot into disease detection, diagnosis and management. The availability of multimodal imaging is an unprecedented advantageous opportunity into …
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