Global ETD Search
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Showing 1 to 20 of 53 for “"African trypanosomiasis"”.
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Population dynamics of African Trypanosomiasis
… of his book The Role of the Trypanosomiases inAfrican Ecology, Ford (1971) argued that quantitative methodsin the tradition of the work of Ross and MacDonald, should beadopted in the study of the epidemiology of thetrypanosomiases. This is now feasible in light of recentadvances in our …
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Macrophage cytokines as correlate of differential resistance to African trypanosomiasis
… macrophages play a central role in resistance to trypanosomiasis. The expression of mRNA and/or production of cytokines (IL-6, IL-10, TNF-α, TGF-β1 and IL-12) and nitric oxide (NO) by macrophages from C57Bl/6 and BALB/c mice in response to 'T. congolense' or 'T. brucei' were studied. The bone …
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African trypanosomiasis : its effect on platelet morphology, function and survival
Thrombocytopenia, occurring sometimes in conjunction with disseminated intravascular coagulation, has been reported sporadically in both human and animal trypanosomiases. The extent of the thrombocytopenia and its relationship to the anaemia and parasitaemia has been investigated in experimental …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
African trypanosomiasis is a disease caused by the Kinetoplastida parasites Trypanosoma brucei rhodesiense and T. b. gambiense. The distribution of the disease is split geographically with T. b. rhodesiense found in eastern sub-Saharan Africa and T. b. gambiense in the west of the continent. …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
<p>Human African Trypanosomiasis (HAT) or African Sleeping Sickness is a disease prevalent in many parts of Sub-Saharan Africa. HAT is a parasitic infection caused by two species, <em>Trypanosoma brucei gambiense</em> and <em>T. b. rhodesiense</em>. Clinical diagnosis is not sufficient as symptoms …
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Examination and management of human African Trypanosomiasis propagation using geospatial techniques
Human African Trypanosomiasis (HAT) is a vector-borne disease transmitted by the bite of the tsetse fly that results in high human morbidity and mortality. The propagation of the disease has been linked to environmental factors, and understanding the vector’s habitat is vital to its control. There …
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Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
A growing problem with drug resistance in Human African Trypanosomiasis has necessitated the implementation of screening programmes to monitor for its spread. This thesis describes the study of several factors that can influence the selection and propagation of drug resistance in T. brucei. Human …
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Determination of the role of cytokines using gene deficient mice in African trypanosomiasis infection
African trypanosomiasis encompasses diseases caused by pathogenic trypanosomes, infecting both humans and animals alike. To determine the immunological role of IL=12 family members in Trypanosoma brucei brucei, Trypanosoma evansi and Trypanosoma congolense infections, IL-12p35¯/¯, IL-12p40¯/¯ and …
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Economic and social consequences of human african trypanosomiasis in Muchinga, Lusaka and Eastern provinces of Zambia
Human African Trypanosomiasis (HAT) causes severe economic production losses in humans due to loss of man power and death. In Zambia most of the studies that have been done have focused on analysing the parasite while none have been conducted to establish the economic consequences of the burden of …
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Prevalence of human African trypanosomiasis and its associated risk factors in Itezhi-tezhi district of Zambia.
Human African Trypanosomiasis (HAT) is a debilitating zoonotic disease caused by trypanosomes which are transmitted by tsetse flies of the genus Glossina. This study aimed to determine the prevalence and risk factors of HAT in Itezhi-Tezhi (ITT) District of Zambia through active surveillance. Human …
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Economic and social consequences of human african trypanosomiasis in Muchinga, Lusaka and Eastern provinces of Zambia
Human African Trypanosomiasis (HAT) causes severe economic production losses in humans due to loss of man power and death. In Zambia most of the studies that have been done have focused on analysing the parasite while none have been conducted to establish the economic consequences of the burden of …
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Epidemiological role of indigenous dogs in the transmission of animal and human African trypanosomiasis in Zambia: a case study of dogs from Mambwe District
In Zambia, African trypanosomiasis (AT) is endemic in tsetse-infested Mambwe district. Although cases are common in livestock, they are rarely reported in dogs. However, recent studies have detected trypanosomes in Zambian dogs. As a follow-up, the current research was designed to investigate what …
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A comparative study on the capacity of Health Workers and Health Centers to diagnise Human African Trypanosomiasis in Tsetse infected Chama and Mambwe Districts of Eastern Zambia
… and compare the levels of knowledge on Human African Trypanosomiasis (HAT), disease awareness among health personnel and factors affecting the diagnostic capacity of HAT in tsetse infested Chama and Mambwe districts of Eastern Zambia. Structured questionnaires were used to collect information …
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An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk in sub-Saharan Africa and up to 50,000 deaths per year caused by …
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Studies of anti-trypanosomal active triterpenoids from some African propolis
… improved drugs for parasitic diseases such as African Trypanosomiasis which is a major global health problem with high endemicity in developing countries due to the alarming rate of resurgence of the disease, drug related adverse effects and drawbacks of the existing useful drugs. Natural …
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Structure- based inhibitor design for key enzymes of <em>Tryposoma brucei</em>
<p>Human African trypanosomiasis (HAT) also known as sleeping sickness is caused by a subspecies of <em>Trypanosoma brucei</em>. These parasites are transmitted by tsetse flies and endanger over 60 million people in Sub-Saharan Africa. Untreated, sleeping sickness is fatal, causing at least 48.000 …
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Investigation of Nigerian Ethno-medicinal Plants as Potential Sources of Cytotoxic and Anti-plasmodial Compounds. Biological activity of Vitellaria paradoxa, Cyperus articulatus, Securidaca longepedunculata and semi-synthetic halogenated analogues of cryptolepine isolated from Cryptolepis sanguinolenta
… of diseases such as cancer, malaria, and human African trypanosomiasis. However, health burdens of such diseases still remain high, with drug resistance leading to failure of current medication. Therefore, there is a need for new treatments, and this project considers the potential of Nigerian …
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Probing Orthologue and Isoform Specific Inhibition of Kinases using In Silico Strategies: Perspectives for Improved Drug Design
… kinase orthologues for treatment in Human African Trypanosomiasis and structural morphology differences between two kinase isoforms that can potentially be exploited for cancer therapeutic design.
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Ferrocenic metal chelators : synthesis, biological and electrochemical studies
… as well as against the causative agent of African trypanosomiasis, Trypanosoma brucei (T. brucei). Of the intermediate thiosemicarbazone thioesters, compound 44y a bipyridyl compound was the most active against both K1 and 307 strains with ED50 values of 0.18 /lg/ml (0.625 /lM) and 0.021 …
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… genus Trypanosoma, the causative agents of human African trypanosomiasis (sleeping sickness) and Chagas disease, while exhibiting no observable cytotoxicity against the MRC-5 human cell line. The side effects associated with most current antitrypanosomal drugs mean that there is an urgent need for …
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