Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"African trypanosome"”.
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Folate transport and drug resistance in the African Trypanosome
… of action and resistance of antifolate drugs in African trypanosomes with a specific focus on transport mechanisms. A media deficient in folate and thymidine was established which enabled the assessment of their modulation on antifolate in vitro potencies and also screen a small set of antifolate …
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
Sleeping sickness, caused by Trypanosoma brucei, is a deadly disease that affects some of the poorest countries in sub-Saharan Africa. Although the disease prevalence is declining, strengthening of the current control efforts, including introduction of more adequate chemotherapeutic options, is …
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African Trypanosome Genes Specifically Required for Fitness <i>in vivo</i>
… a specific loss of fitness in vivo. Analyses of African trypanosome biology are often carried out in HMI culture medium which is rich in nutrients and may not necessarily be representative of the environments encountered in vivo. We reasoned that parasites in vivo are likely to display increased …
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Tracking the In Vivo Dynamics of Antigenic Variation in the African Trypanosome
<p>Trypanosoma brucei, a causative agent of African sleeping sickness in humans and nagana in animals, constantly changes its dense variant surface glycoprotein (VSG) coat to avoid elimination by the immune system of its mammalian host, using an extensive repertoire of dedicated genes. Although …
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Proteomic, Bioinformatic and Functional Characterization of the Nuclear Pore Complex of the African Trypanosome
… analysis of the protein components of the trypanosome NPC. Towards this end, we used several biochemical and proteomic strategies to identify the proteins that associate with a preparation of enriched T. brucei NEs. Discerning authentic trypanosome Nups from the 859 proteins identified was …
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Expression and behaviour of GPI-anchored surface proteins in trypanosomes
… and tissue spaces of vertebrate hosts. African trypanosome species have evolved a variant surface glycoprotein (VSG) coat which underpins a population survival strategy based on antigenic variation. However, the vast majority of trypanosome species do not use this strategy and our …
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Investigation of the interactions between Trypanosoma congolense invariant surface glycoproteins and components of the mammalian immune system
African trypanosomes are single-celled eukaryotic pathogens of humans and animals. As they are extracellular in vertebrate hosts, their cell surface forms the primary host-pathogen interface. Invariant surface glycoproteins (ISGs) are a large family of cell surface proteins with recent expansion …
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Epidemiological role of indigenous dogs in the transmission of animal and human African trypanosomiasis in Zambia: a case study of dogs from Mambwe District
In Zambia, African trypanosomiasis (AT) is endemic in tsetse-infested Mambwe district. Although cases are common in livestock, they are rarely reported in dogs. However, recent studies have detected trypanosomes in Zambian dogs. As a follow-up, the current research was designed to investigate what …
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A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly immunity factors are key determinants in the success and failure of infection …
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Functional characterisation of cohesin subunit SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei
The genome of the African trypanosome, Trypanosoma brucei, presents an unusual karyotype in which two main classes of chromosomes, large and small minichromosomes, need to be faithfully replicated and segregated during the cell cycle. Although the large and minichromosomes are colocalised and …
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Structure of the trypanosome transferrin receptor and insights into ligand binding and therapeutic strategies
African trypanosomes are extracellular protozoan pathogens that have evolved a complex and sophisticated interface with hosts to acquire nutrients and protect against the host immune system. The variant surface glycoprotein (VSG) forms a dense and dynamic protective coat, which serves to defend …