Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"African sleeping sickness"”.
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A Pharmacological Strategy Against African Sleeping Sickness
… and is the causal agent of the disease known as African sleeping sickness, transmitted via the bite of a tsetse fly. If left untreated, the parasite ultimately crosses the blood-brain eventually leading to death. Currently there are 5 approved drugs used to treat it, each with toxic side effects …
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The role of transition fibre proteins in regulating CEP164C assembly and localisation to the flagellum in the African Sleeping Sickness parasite Trypanosoma brucei
… Trypanosoma brucei, a paristie responsible for African trypanosomiasis. We focus on proteins within the transition fibres of the basal bodies, essential for flagellum assembly and cell division in the procyclic cycle.. In particular, CEP164C is thought to be a key organiser of the transition …
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Small molecule inhibitors of parasitic enzymes
… proteases from the causative agents of Malaria, African sleeping sickness and Chagas disease, (ii) development of potential new and novel anti-trypanosomal inhibitors of trypanosome alternative oxidase, and (ii) synthetic and methodological studies.
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Developing New Chemotherapeutic Agents Against Bone Resorption and Parasitic Diseases Through Computer -Aided Drug Design
… of Trypanosoma brucei, the causative agent of African sleeping sickness. These predictive models aid in optimizing existing inhibitors and ultimately designing novel ones.
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RNA genome annotation with a focus on T. brucei
… is an interesting organism, and as the cause of African sleeping sickness -- which infects 300,000-500,000 people and a significant number of cattle annually -- is currently the subject of considerable research. Using existing algorithms, several patterns have been found that may lead to more …
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Canada's Contribution to Neglected Tropical Disease Research: A Co-authorship Network Analysis
… NTD researchers specialize in Leishmania and African sleeping sickness research and are mainly affiliated with academic institutions within Canada (McGill University, Laval University and University of British Columbia). International co-authorship activity is largely with OECD countries …
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New Chemotherapeutic Approaches for the Treatment of Parasitic Protozoan Diseases
… falciparum. These parasites are responsible for African sleeping sickness, South American trypanosomiasis (Chagas' disease), toxoplasmosis, leishmaniasis, and malaria, respectively. The studies contained within this thesis were carried out in three main areas: (a) demonstration of selective …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
<p>Human African Trypanosomiasis (HAT) or African Sleeping Sickness is a disease prevalent in many parts of Sub-Saharan Africa. HAT is a parasitic infection caused by two species, <em>Trypanosoma brucei gambiense</em> and <em>T. b. rhodesiense</em>. Clinical diagnosis is not sufficient as symptoms …
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NMR, Crystallographic and Quantum Chemical Studies of Metalloproteins and Bisphosphonate Inhibitors
… from Trypanosoma brucei (the causative agent of African sleeping sickness) is expressed in E. coli and purified for crystallographic studies. Single crystals of both drug-free and drug-bound FPPSs are obtained and diffract to 3.3 A and 2.5 A, respectively, using synchrotron radiation. A …
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Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
… of several neglected tropical diseases such as African sleeping sickness, Chagas disease, and Leishmaniasis. Newly available sequences of many kinetoplastid genomes were used to reconstruct evolution of trafficking across this lineage, using three central paralogous trafficking families: Rabs, …
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Determination of the roles of the Trypanosoma brucei lipin homologue TbLpn
African Sleeping Sickness is caused by Trypanosoma brucei. T.b is a parasitic protozoan that affects humans and other animals alike in sub-Saharan Africa. Epidemics have occurred throughout the 20th century, including Uganda and Kenya in 1900 and Alego and Kenya from 1976 to 1983. Due to its …
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Tracking the In Vivo Dynamics of Antigenic Variation in the African Trypanosome
<p>Trypanosoma brucei, a causative agent of African sleeping sickness in humans and nagana in animals, constantly changes its dense variant surface glycoprotein (VSG) coat to avoid elimination by the immune system of its mammalian host, using an extensive repertoire of dedicated genes. Although …
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Proteomic Approaches For Profiling Cofactor-Dependent Proteins In Mycobacterium Tuberculosis
… therapeutic targets for pathologies ranging from African sleeping sickness to epilepsy. A full catalog of all PLP-dependent enzymes in Mtb has been compiled and references provided on any drug discovery done at that target. Given the broad nature of the activities within this family of enzymes, we …
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Systems biology approaches to the computational modelling of trypanothione metabolism in Trypanosoma brucei
… Trypanosoma brucei, the parasite responsible for African Sleeping sickness. Trypanothione has previously been identified as an essential compound for parasitic protozoa, however the underlying metabolic processes are poorly understood. Structural modelling allows the study of the network …
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Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
… Anopheles mosquito, which feeds on human blood. African Sleeping Sickness is an acute disease 8 caused by Trypanosoma brucei that typically leads to death within weeks or months if not treated. Microtubule-associated proteins (MAPs) and their alteration of the unique microtubule (MT) systems play …
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Seventy years of changes in riverine woodland cover: Responses to elephants and human legacy effects in Gonarezhou National Park, Zimbabwe
… and overpopulation can occur. In southern African savanna systems, large populations of savanna elephant (Loxodonta africana) are transforming woodland and reducing vegetation diversity. While historically large, the elephant population in Gonarezhou National Park in Zimbabwe has grown at …
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Telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
… In Trypanosoma brucei, the causative agent of African trypanosomiasis, the surface coat consists of a dense layer of Variant Surface Glycoproteins (VSG). The actively transcribed VSG is found in one of ~20 telomeric Expression Sites (ES). Antigenic variation can occur by transcriptional …