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Showing 1 to 12 of 12 for “"African horse sickness"”.
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Development of plant-produced African horse sickness vaccines
African horse sickness is a devastating disease that causes great suffering and many fatalities amongst horses in sub-Saharan Africa. It is caused by nine different serotypes of the orbivirus African horse sickness virus (AHSV) and it is spread by Culicoid midges. The disease has significant …
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Echocardiographic evaluation of horses challenged with African horse sickness virus
African horse sickness (AHS) is an infectious, often fatal viral disease of equids with a severe impact on the equine industry in sub-Saharan Africa. Clinicopathological mechanisms are poorly understood, and there is limited information on the degree and type of cardiac involvement. This study …
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Characterisation and expression of ORF2 in genome segment 10 of African horse sickness virus
… open reading frame, ORF2, was identified in African horse sickness virus (AHSV) Seg-10 which encodes the non-structural protein NS3. The ORF2 conservation, size, nature, expression, function and potential subcellular localisation of the putative protein product AHSV is not known and is …
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Investigating the production of a particulate plant-produced vaccine candidate against African horse sickness
African horse sickness (AHS) is a non-communicable, infectious disease that affects equids and is mainly prevalent in sub-Saharan Africa. The disease has a major impact on the economy of the equine industry as well as an emotional impact on horse owners. There are nine known serotypes of African …
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The Development of an African Horse Sickness Virus VP7 Quasi-Crystal Vaccine Candidate in N. benthamiana
African horse sickness (AHS) is a debilitating viral disease affecting equines and has resulted in many disastrous epizootics. To date, no successful therapeutic treatment exists for AHS and the commercially used live-attenuated vaccines (LAVs) have various side effects. Insoluble particulates have …
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Identifying B-cell epitopes of African horse sickness virus serotype 4 recognised by antisera of immunised horses
African horse sickness is an infectious, insect-borne but non-contagious disease of equids responsible for more than 95% mortality in naïve horses. The African horse sickness virus has ten segments of double stranded RNA encoding seven structural and three non-structural proteins. There is …
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Characterizing the effect of mutation recombination and reassortment on the genetic diversity of African horse sickness virus genomes
African horse sickness virus (AHSV) is a member of the Orbivirus genus within the Reoviridae family and the aetiological agent for African horse sickness (AHS). It is an arthropod-borne virus transmitted by biting midges belonging to various Culicoides spp. Nine antigenically distinct AHSV (AHSV …
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Reagents and Tools to Identify Epizootic Hemorrhagic Disease Virus-2
… which also includes Bluetongue Virus and African Horse Sickness, which are all transmitted through arthropod vectors. EHDV causes significant morbidity and mortality in white-tailed deer, but has recently been found to infect cattle. EHDV recently caused significant outbreaks affecting …
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Use of baculovirus surface display for characterization of AHSV4-VP2 antigenic structure
African horse sickness is an infectious, non-contagious, insect vector-borne disease of equids. It is highly lethal and mortality rates can exceed 90% in susceptible populations. The disease is caused by African horse sickness virus (AHSV), which is mostly endemic in sub-Saharan Africa. However, …
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Expression and characterization of plant produced AHSV nanoparticles encapsulating EGFP
… protein (EGFP), to the VP3 structural protein of African horse sickness virus (AHSV). Plant-based transient expression of the AHSV EGFP-VP3 and AHSV VP7 structural proteins has been used to generate CLPs from N. benthamiana leaves that successfully encapsulate the EGFP protein. However, …
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The characterisation of aspects related to the single stranded RNA binding ability of African horsesickness virus nonstructural protein NS2
African horsesickness virus (AHSV) is a member of the Orbivirus genus and part of the family Reoviridae. It is a double stranded RNA virus with ten genome segments that encode seven structural and four nonstructural proteins. AHSV nonstructural protein NS2, encoded by segment eight, is a single …
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Development of a single real-time RT-PCR method for the group-specific identification of African horsesickness virus and bluetongue virus
African horsesickness is an infectious but non-contagious disease caused by an orbivirus belonging to the Reoviridae family. The disease is classified as notifiable by the OlE because of the potential severe economic consequences that can result from outbreaks. Bluetongue, an arthropod-transmitted …