Global ETD Search
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Showing 1 to 20 of 29 for “"Aflatoxin B1"”.
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… the relationship between DNA repair mechanisms, aflatoxin B1 (AFB1)-induced DNA damage and carcinogenesis. Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed to a single …
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Interaction of aflatoxin B1 with the ribosomal RNA genes of rat liver
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nutrition and Food Science, 1983.
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Interaction of aflatoxin B1 with DNA in vivo in the rat and mouse
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1979
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Chemoprotective action of natural products on cultured human epithelial cells exposed to aflatoxin B1
Submitted in fulfilment of the requirements for the Degree of Doctorate of Technology: Biotechnology, Durban Institute of Technology, Durban, South Africa, 200.
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Design Synthesis and Evaluation Of Diterpenones As Potent Chemopreventive Agents For Aflatoxin B1 Induced Carcinogenesis In Human Liver Cells
… AS POTENT CHEMOPREVENTIVE AGENTS FOR AFB1 INDUCED CARCINOGENISIS IN HUMAN LIVER CELLS By Miguel A. Zuniga, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Major Director: Qibing Zhou, …
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Evaluation of aflatoxin-related products from ozonated corn
… efficacy of the ozonation process in degrading aflatoxin in corn, and investigated the chemical reaction between aflatoxin and gaseous ozone. Ozonation (12-13 wt%) totally degraded aflatoxin B1 in a model system. Conversion of aflatoxin into polar compounds was observed during ozonolysis of 100 …
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Development of a novel monoclonal antibody-based immunoaffinity column for the detction of aflatoxins
… F1 hybrid mice immunised intraperitoneally with aflatoxin B1 and ochratoxin A protein conjugates. The main characteristic of these monoclonal antibodies is their ability to bind sufficiently better to all four main aflatoxins and ochratoxin A than other antibodies already on the market. Past …
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Development of a collagen gel sandwich hepatocyte bioreactor for detecting hepatotoxicity of drugs and chemicals
… EGF in the medium. The toxins we examined were aflatoxin B1, acetaminophen, carbon tetrachloride, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), methyl methane sulfonate (MMS), cadmium, vinyl acetate and dimethylformamide (DMF). The cells were sensitive to aflatoxin B1, MMS, MNNG and cadmium. …
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Human aflatoxin exposure in south-western Ethiopia assessed using serum biomarkers: A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science at Lincoln University
Aflatoxins are secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus. Consumption of aflatoxin-contaminated food can cause hepatocellular carcinoma, immune suppression, child growth impairment, and death. The study aimed to assess aflatoxin exposure in South-western …
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Combining ability study for the development of resistance to Aflation contamination by Aspergillus flavus link ex fries in groundnuts
… infection by Aspergillus flavus and subsequent aflatoxin contamination. Although there are several management strategies that may reduce aflatoxin contamination of groundnuts, the pre-eminent strategy for the prevention of aflatoxin is to develop host resistance to Aspergillus flavus. A …
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Combining ability study for the development of resistance to Aflation contamination by Aspergillus flavus link ex fries in groundnuts
… infection by Aspergillus flavus and subsequent aflatoxin contamination. Although there are several management strategies that may reduce aflatoxin contamination of groundnuts, the pre-eminent strategy for the prevention of aflatoxin is to develop host resistance to Aspergillus flavus. A …
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Post-harvest strategies for the prevention of fungal growth and mycotoxin production in corn
… large inhibitory effect on growth and fumonisin B1 production by the Fusarium isolates. Models were developed that adequately described the interaction observed between the CO2 and water activity on the growth of the Fusarium isolates. Although the initial headspace O2 level did not affect the …
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Osmoregulatory role of the intestine in fish physiology. Evolutionary, environmental, and toxicant implications
… aquafeeds' effects contaminated with aflatoxin B1 on growth performance and intestinal physiology are also examined, using gilthead seabream (Sparus aurata), a well-known farmed biological model.
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Transcriptional response and DNA adduct analysis of murine liver exposed to aflatoxin B₁ by Jeanette Louise Allen Fiala.
Human dietary exposure to aflatoxin B1 (AFB1) is linked to hepatocellular carcinoma (HCC), especially in areas where significant hepatitis B infection is concurrent. Susceptibility to this carcinogen varies among species. Neonatal mice, like rats and most other species, are highly sensitive to the …
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The toxicity and mutagenicity of the aflatoxin B₁ formamidopyrimidine DNA adduct
Aflatoxin B1 (AFB1) is a fungal metabolite that contaminates the food supply in certain areas of the world. It is produced by Aspergillusflavus and related fungi that grow on improperly stored foods such as corn, rice, and peanuts. Epidemiological studies have shown a correlation between exposure …
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Etude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
… plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 …
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Regulation of cytochrome P450 genes in drosophila melanogaster by the chemical environment
… D. melanogaster strain to the fungal toxin, aflatoxin B1, a natural constituent in the diet. Next, I investigate the duplication of a xenobiotic-responsive P450 in D. melanogaster and across 11 Drosophila species and examine the changes incurred in a strain selected for DDT resistance. …
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The ontogeny of the immune response to sheep erythrocytes and resistance to aflatoxins in chickens
… the ontogeny, kinetics, and the influence of aflatoxin B1 on antibody response to sheep erythrocyte (SRBC) antigen in White Leghorn chickens. In the first experiment, chickens from the parental lines and reciprocal crosses between them were fed diets containing graded levels, from 0 to 5697 …
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The Roles of a Conserved MAP Kinase Pathway in the Regulation of Development and Secondary Metabolism in Aspergillus Species
… such as the highly carcinogenic compound aflatoxin B1. This species is considered a major global threat as it is capable of causing contamination of a wide variety of agricultural crops and ingestion of crops contaminated with aflatoxin can lead to the development of hepatocellular …
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