Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"Affymetrix"”.
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Probe Level Analysis of Affymetrix Microarray Data
The analysis of Affymetrix GeneChip® data is a complex, multistep process. Most often, methodscondense the multiple probe level intensities into single probeset level measures (such as RobustMulti-chip Average (RMA), dChip and Microarray Suite version 5.0 (MAS5)), which are thenfollowed by …
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DNA Microarray Data Analysis and Mining: Affymetrix Software Package and In-House Complementary Packages
… challenge for microarray studies. In this study, Affymetrix software was used to analyze an HIV-infection data. The microarray analysis shows remarkably different results when using different parameters provided by the software. This highlights the fact that a standardized analysis tool, …
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Single nucleotide polymorphism array analysis in copy number variant detection: assessment of its feasibility in the diagnostic setting
… identified with conventional cytogenetics. The Affymetrix® Cytoscan™ High Density (HD) Array (Affymetrix, Santa Clara, CA) containing over 2.4 million markers for copy number (CN) was used to detect genome-wide high resolution CN and single nucleotide polymorphisms (SNPs) in a cohort of 27 …
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Molecular cytogenetics and genetic characterisation of chromosomal rearrangements
… nucleotide polymorphism (SNP) microarrays; Affymetrix 250K SNP microarrays (n=14) and Affymetrix SNP6.0 (n=2). Assuming complete penetrance, a critical region for congenitalheart disease (CHD) susceptibility gene was refined to approximately 200 kb and a candidate critical region for mental …
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An Interactive Natural Host Model System for a Swine Alphaherpesvirus: Aujeszky's Disease Virus Cell Interactions in Immortalized Porcine Olfactory Neuroblasts
… a non-neuronal cell line, again by utilizing the Affymetrix array chip. The conducted studies exerted a highly cell-specific transcriptional response with neuron-specific attributes in the swine neuronal cell line.
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Extending the Graphical Representation of four KEGG Pathways for a Better Understanding of Prostate Cancer Using Machine Learning of Graphical models
… networks are discussed. The work is based on Affymetrix gene expression microarray profiles and penalised Gaussian linear models. Penalisation in linear models includes choosing the most important parents and estimating the associated coefficients simultaneously using L1-regression. The sparse …
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Studies of Genetic and Epigenetic Determinants of Prostate Cancer
… second study, Jianfeng Xu et al. performed an Affymetrix SNP microarray analysis of 78 human PCa tissues to determine the correlation between genetic alteration and PCa occurrence/progression. From their analysis, we focused on chromosome 8p found to be frequently loss in ~60% of human PCa …
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BMEA: Bayesian Modelling For Exon Array Data
The development of Affymetrix Exon Arrays was a signifcant step forward from 3' Microarray technology, however detection of alternate splicing events proved challenging. In this work a novel method, Bayesian Modelling for Exon Arrays (BMEA), is described which shows an improvement in performance …
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Molecular genetics of abdominal aortic aneurysm
… the Human Genome (HG) -U133 plus 2.0 microarray (Affymetrix) that interrogates the whole human genome. The robustness of the genearray was assessed using data output quality control as defined by Affymetrix. Statistical analysis was then carried out using the GeneSpring software. Genes were …
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An Analysis of the Arabidopsis Aquaporin TIP1;1 and Analysis of Stress Response Signaling in Arabidopsis
… were studied, using publically available Affymetrix ATH1 microarray data. The salt stress signaling pathways were dissected, by comparing the salt stress response to other abiotic/biotic stress responses or the response to plant hormones. The analysis, focused on the salt regulated genes, …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… and cRNA was prepared and hybridised to Affymetrix HG-133A (Exp.1) and HG-133A_2 (Exp.2) gene chips. Data were analyzed using a combination of the MAS 5.0 (Affymetrix) and GeneSpring (Agilent) software programmes. Significant change in gene expression was defined as greater than two fold …
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Statistical methods for genetics and genomics studies
… our approach used the probe intensities that the Affymetrix software associates with each microarray. The effectiveness and improvements of the proposed method over the existing methods are illustrated by the application of the method to the previously published 19 human Affymetrix microarray data …
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Non-parametric algorithms for evaluating gene expression in cancer using DNA microarray technology
… derived from different research groups using the Affymetrix GeneChip^{TM} platform. A key finding of this study is that selectively expressed genes are very powerful when used for disease classification. A model was designed to reduce noise and eliminate false positives from true results. With …
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Genome-wide Association Study of TDI-Induced Asthma in a Korean Population : Signofocant Association of a T-catenin(CTNNA3) and TRP channel gene-gene interaction
"연구목적: Affymetrix 500K 유전자칩을 이용하여 TDI 천식환자와 정상인 간의 전체 게놈 연관성 연구 (genome-wide association study)를 진행하여 TDI 천식의 병인기전에 관여하는 유전적 변이를 찾아보고 유의한 의미를 가지는 유전적 변이에 대해 유전자-유전자 (gene-gene) 상호작용 분석을 통하여 유전적 변이간의 관계를 알아보고자 한다. 연구방법: 직업성 천식인 TDI천식 환자 84명과 건강한 정상인 263명에 대하여 Affymetrix 500K 유전자칩을 사용하여 대량의 유전적 변이들의 …
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Plant responses to environmental stimuli: A screen for mutants aberrant in TCH4 expression behavior, and a full-genome assessment of touch and darkness inducibility
… large-scale gene expression experiment utilizing Affymetrix ATH1 microarrays which focuses on the short-term responses of plants to touch and darkness. These chips enable an expression level survey of over 22,000 genes simultaneously. We identify 589 genes that have increased expression in plants …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… in mediating GC effects at the growth plate. Affymetrix microarray has been used to identify and characterise the expression of lipocalin 2, a novel GC-responsive chondrocyte gene which may contribute to GC-induced growth retardation in the growth plate. In vitro and in vivo studies have also …
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Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
… mice was investigated using a whole mouse genome Affymetrix array.
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Detecting Changes in Alternative mRNA Processing From Microarray Expression Data
… <p>Adaptation of SplicerAV to the new Affymetrix Human Exon arrays has resulted in the creation of SplicerEX, the first program that can automatically categorize microarray detected changes in alternative processing into biologically pertinent categories. We use SplicerEX's automatic …
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Utilizzo della tecnologia microchip per l'identificazione di geni candidati responsabili dell'aumento di HbF.
… were run on 14 TD and 14 NTD patients using the Affymetrix 500K (500,568 SNPs) SNP chip platforms. The average sample cali rates were 94.3% for the 500K chip. Additional samples are being analyzed in an attempt to achieve sufficient power to reach genome-wide significance.
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Development of a software infrastructure to mine GeneChip expression data and to combine datasets from different Medicago truncatula expression profiling platforms
… expression of thousands of genes in parallel. Affymetrix GeneChips®, more recently designed gene-specific chips, make it easier for the researcher to compare and evaluate gene expression and thus will most certainly lead to more accurate results. Not surprisingly, Medicago GeneChips® are moving …
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