Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 551 for “"Aetiology"”.
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Eating behaviour and the aetiology of obesity
… of the association between EB and the aetiology of obesity. Across 5 studies, a combination of approaches was used to interrogate: (1) the role of EB in genetic predisposition to obesity, (2) the interaction between infant EB and maternal attitudes in the determination of infant milk …
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Elucidating the genetic aetiology of Bipolar Disorder
Introduction: Bipolar disorder (BD) is a debilitating mood disorder with substantial genetic contributions. However, while the existence of its heritability is well-established, the precise genetic components and mechanisms of BD remain unknown. This is a pilot study aimed at optimising the use of …
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The aetiology and pathogenesis of tropical ulcer
Tropical ulcer is a very specific form of cutaneous ulceration. It occurs worldwide in most tropical and a number of subtropical areas. The disease occurs mainly in older children and young adults with children under the age of 5 and adults over 45 years rarely being affected. Ulcers occur most …
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Peripheral Arterial Disease from Aetiology to Surgical Management
The work presented includes over thirty peer reviewed published manuscripts based on studies undertaken during my surgical career. As Principal Investigator, I led the study conception/design/data acquisition/analysis/interpretation and was involved with writing the final drafts of all manuscripts …
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The Genetic Aetiology of Ectopic Maxillary Canine Teeth
… appearing in 1-2% of the Western population The aetiology is controversial with opinion divided as to a genetic or environmental mechanism. This study addresses the hypothesis that genetic factors play an important role in the aetiology of ectopic maxillary canines. Elucidation of the extent of …
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Studies in Aetiology and Historical Methodology in Herodotus
… existing scholarly paradigms regarding aetiology in the Histories of Herodotus in order to open up new avenues to approach a complex and varied topic. Since aetiology has mostly been treated as the study of cause and effect in the Histories, this work expands the purview of aetiology to …
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Aetiology of fatigue during maximal and supramaximal exercise
The aim of this thesis was to investigate the extent of peripheral and central components in the development of fatigue during maximal exercise. Fatigue during maximal and supramaximal excercise has traditionally been modelled from the peripheral context of an inadequate capacity to supply …
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The role of genetic factors in breast cancer aetiology
Breast cancer is the most common cancer in women and is also the leading cause of cancer<br/>mortality in women. There are several known risk factors for breast cancer including genetic<br/>factors which account for at least 25% of the incidence of breast cancer, although only a …
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The aetiology of pain in chronic midportion Achilles tendinopathy
Background Achilles tendinopathy (AT) is a common injury in athletes and sedentary individuals, which presents as pain and loss of function in the lower limb. Tendon pathology can exist without pain, but the hallmark of the condition is pain, which is classically of insidious onset, related to …
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Posterior Laryngitis- Aetiology,Treatment and Health-Related Quality of Life
Posterior laryngitis (PL) is defined as an inflammation involving the posterior part of the glottal region in conjunction with symptoms. The cause is multifactorial. The aims of the work presented in this thesis were to examine symptoms, physical signs, different aetiologies and health-related …
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Respiratory Tract Infections: Aspects of Aetiology, Virulence, and Communicable Disease Control
… these bacteria. Pneumococci are the predominant aetiology of bacterial respiratory tract infections and a major cause of morbidity and mortality, in the most severe cases due to invasive pneumococcal disease (IPD; mainly sepsis and meningitis).The development and spread of resistant pneumococci …
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Current Concepts in the Aetiology, Pathogenesis and Management of Kienbock’s Disease
… by the Viennese radiologist, Robert Kienböckthe aetiology, pathogenesis and management of Kienbock’s Disease has been debated. The disease encompasses a spectrum of age and gender but is classically considered to affect young-to-middle-aged male manual laborer’s. Both mechanical and vascular …
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Concussion, neck, and hamstring injury aetiology and injury prevention in Rugby Union
ABSTRACT Background Concussion and hamstring injuries are two of the most frequently diagnosed injuries in Rugby Union. Neck and hamstring strength have been identified as a modifiable risk factor to decrease the severity and incidence of these injuries. As such, there is an increasing interest in …
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Statistical Techniques to Fine Map the Related Genetic Aetiology of Autoimmune Diseases
Genome Wide Association Studies (GWAS) have uncovered many genetic regions which are associated with autoimmune disease risk. In this thesis, I present methods which I have developed to build upon these studies and enable the analysis of the causal variants of these diseases. Colocalization methods …
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Understanding the Aetiology of Metabolic Diseases and Related Phenotypes through Human Genetics
A key objective in human genetics is to elucidate how inherited genetic variations contribute to the phenotypic variations and disease susceptibility in the population. Whole-exome sequencing (WES) is a pivotal approach for uncovering gene-disease associations by analysing rare variants that can …
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Delayed graft function in renal transplantation : aetiology and impact on graft outcome
The optimal therapy for most patients with end stage renal disease is renal transplantation. This form of therapy results in improved quality of life, decreased medical expense, and perhaps a survival advantage for the recipient. Renal transplantation is however a complex form of therapy which may …
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Investigating the role of rare genetic variants in the aetiology of haemostasis disorders
… investigate the role of genetic variants in the aetiology of haemostatic diseases. To explore the contribution of rare coding variants to the different phenotypes, I selected all the pathogenic and likely pathogenic variants from a few well-curated resources. Then, I identified carriers of these …
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Incidence, prevalence and aetiology of chronic exercise induced lower back pain in runners
… and any initiating or aggravating factors. The aetiology of low back pain in runners was also investigated. A random sample population of 225 roadrunners were interviewed following the completion of six local road races. A further subgroup (n = 52) (LBP group as well as control group) of these …
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