Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Aerosol delivery"”.
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Effervescent proliposomes for aerosol delivery to paranasal sinuses
… potential suitability of liposomes generated for aerosolization to target paranasal sinuses. Novel effervescent proliposomes prepared with Soya phosphatidylcholine (SPC) and Dipalmitoylphosphatidylcholine (DPPC) successfully generated stable liposomes with an improved disintegration time of less …
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Aerosol delivery of Rhodoccocus equi IgG to the lungs of ponies
… using a low volume endoscopic technique prior to aerosolization (time 0), and at 1 hr, 6 hrs, and 24 hours post administration. The BAL fluid total IgG concentration and R. equi specific IgG titers were determined via ELISA and cytologic analysis was performed. No clinically significant local …
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Design of experimental apparatus for generation and measurement of an aerosol
… degree. In this work, a system for generating aerosol delivery into shock tube for interface creation and a method to measure aerosol is developed. In chapter 1, a brief introduction of hydrodynamic instabilities later focussing on shock driven multiphase instabilities (SDMI) and its importance …
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Synthesis and biological studies of a fullerene-Taxol conjugate and fullerene-based transfection vectors
… of C60 as a slow-release system for the liposome aerosol delivery of lipophilic chemotherapeutics to lung cancer. TaxolRTM (paclitaxel), one of the most active anticancer drugs in clinical use, has shown significant potential for treatment of lung cancer when delivered by the liposome aerosol …
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Development Of A Supercontinuum Based Photoacoustic Aerosol Light Absorption And Albedo Spectrometer (PALAAS)
Aerosols are a major contributor to the global radiation budget because they modify the planetary albedo with their optical properties. These optical properties need to be measured and understood, ideally at multiple wavelengths. This thesis describes the ongoing development of a supercontinuum …
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Spray Techniques And Lung Cancer Chemoprevention
… of administration. The primary advantages of aerosol delivery in treating lung diseases include improving the bioavailability of the drug in the lung, decreasing the medicine dose, rapid action, and reducing the systemic toxicity as well as side effects. Spray techniques are widely used for …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
… may potentially result in adverse side effects. Aerosol delivery, on the other hand, offers many advantages over conventional routes of administration for diseases of the respiratory tract and the lungs. These advantages include the extensive pulmonary surface area available for drug deposition, …
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Numerical Analysis of Respiratory Aerosol Deposition: Effects of Exhalation, Airway Constriction and Electrostatic Charge
… particle deposition and medical respiratory aerosol delivery. Computational fluid-particle dynamics (CFPD) can play a critical role in developing a better understanding of particle laden flows, especially in a number of under-explored areas. The applications considered in this study include …
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Strategies to improve BCG-mediated protection from <i>Mycobacterium tuberculosis</i>
… T cell responses in the spleen, only intranasal delivery elicited specific T cell responses in the lung lymph nodes and these responses were further boosted by intranasal delivery of MVA85A. Following aerosol challenge of BALB/c with <i>Mycobacterium tuberculosis</i>, intranasal boosting of BCG …
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Strategies to Target the Bone Morphogenetic Protein Signalling Pathway in Lung Disease
… as a whole. New and refined mechanisms of drug delivery for the prevention, cure or delayed progression of disease, represents a pathway for the delivery of novel style therapies and for the targeted delivery of different of more toxic drugs to the airways in order to increase efficiency of both …