Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Adverse Drug Reactions"”.
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Adverse drug reactions in hospital inpatients
Adverse drug reactions (ADRs) are a significant public health problem. This thesis examined the incidence and nature of adverse drug reactions following admission to hospital. An initial pilot study was conducted to develop methodology, which was then utilised in a study of 3695 patients. …
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Pharmacist input into patients' self-reporting of adverse drug reactions.
Adverse drug reactions (ADRs) are common and should be reported to the CSM, particularly for newly marketed drugs. There is under-reporting of ADRs by doctors. Involving the patient in self-reporting, particularly when initiated by pharmacists is feasible and could help to improve reporting rates. …
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The burden of serious adverse drug reactions in South Africa
Background The burden of serious adverse drug reactions (ADRs) in South Africa (SA) is not well characterised, and may be influenced by the high HIV prevalence. This thesis aims to describe this burden, by reporting findings of three hospital-based surveys of (1) ADRs causing death among adult …
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Predicting unknown adverse drug reactions using an unsupervised node embedding algorithm
… that occur during or after usual clinical use, Adverse Drug Reactions (ADRs) pose a major health risk and result in the hospitalization of millions of patients each year. While pre-marketing clinical trials evaluate the safety and efficacy of a new drug, post-marketing surveillance identifies …
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Strategies to prevent potentially inappropriate prescribing and adverse drug reactions in older patients
… prescribing (PIP) is a major contributor to adverse drug reactions and overall increased healthcare costs. The aim of this thesis was to identify, develop and implement strategies with the potential to prevent PIP and ADRs in older patients. METHODS: A systematic review of the qualitative …
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A multi-agent intelligent system for detecting unknown adverse drug reactions through communication and collaboration
<p>Several thousands of drugs are currently available on the U.S. market. A complete understanding of the safe use of drugs is not possible at the time when drug is developed or marketed. At that time, the safety information is only obtained from a few thousand people in a typical pre-marketing …
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The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study
Lithium is regarded as the first-line pharmacotherapy for the treatment of acute mood episodes, suicide prevention and prophylactic treatment in patients with bipolar disorder (BPD). Response to lithium has a strong genetic component and lithium-responders have an increased frequency of BPD among …
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Prevalence of anxiety and depression in a predominantly HIV-infected population with severe cutaneous adverse drug reactions
… and depression in subjects with severe cutaneous adverse drug reactions (SCADR), in a predominantly HIV - infected population. The aim of the study was to prospectively investigate the prevalence of anxiety and depression and quality of life in patients with SCADR. Methods: In this prospective …
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Evaluation of the costs of managing cutaneous adverse drug reactions to first-line TB therapy in South African TB patients
… of effective TB control programmes. However, TB drugs are often associated with adverse drug reactions (ADR) that affect treatment adherence and cure. Cutaneous adverse drug reactions (CADR) are more commonly associated with Human Immunodeficiency Virus (HIV)/TB co-infection, occurring in up to …
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“I never thought there could be anything worse than cancer but chemo is": Adverse Drug Reactions in a Children's Oncology Unit
Adverse drug reactions (ADRs) are common in children and young people and contribute significantly to morbidity, mortality and hospital costs more so in children who are cared for within the speciality of oncology. There is little research that addresses how ADRs impact on children and young people …
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Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with presence of depression.
… has not been studied in severe cutaneous adverse drug reactions (SCAR). Objective: To determine DHEA/HCC correlation with SCAR-associated depression and compare the ratio with published values. Methods: Depression was assessed using M.I.N.I. and DHEA/HCC measured in epidermal necrolysis …
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Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with presence of depression.
… has not been studied in severe cutaneous adverse drug reactions (SCAR). Objective: To determine DHEA/HCC correlation with SCAR-associated depression and compare the ratio with published values. Methods: Depression was assessed using M.I.N.I. and DHEA/HCC measured in epidermal necrolysis …
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Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms
… that catalyse a diverse range of biological reactions. They are responsible for over 80% of primary metabolism of currently available drugs and are therefore central to its medical importance. Investigating the effects of these enzymes on drugs by metabolite detection and kinetic studies is a …
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The Prevalence of Antiretroviral-Therapy-related Adverse Reactions, Hospitalisation, and Mortality among People Living with HIV in Africa-A systematic review and Meta-Analysis
… one of the major concerns remains the risk of adverse drug reactions when used by consumers. Adverse drug reactions place a burden on the healthcare system, usually as a result of complications requiring hospital admission or extended hospital admissions. In Africa, about 28.6% of adverse drug …
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Does the inclusion of the cost and burden of adverse drug reactions associated with drug-resistant TB treatment affect the incremental cost-effectiveness of new treatment regimens? A case study from the introduction of bedaquiline in South Africa National TB Programme
… highest burdens of TB, HIV/TB co-infection, and drug-resistant TB. Second-line TB treatment is less effective, more expensive, and more toxic than treatment for drug-sensitive TB. Nearly 1 in every 5 persons who starts treatment for drug-resistant TB in South Africa will die; 1 in every 3 persons …
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A Clinical Characteristics of Adverse Drug Reaction in Pediatrics
PURPOSE: The drugs used for prevention of disease, medical treatment and research sometimes show the undesired adverse drug reactions. These unexpected adverse drug reactions are typically not related with the used capacity nor with pharmacological mechanism of individual drug. Thus, attention …
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Extensively drug resistant tuberculosis in South Africa
… of another 115 patients, retrospectively, for adverse drug reactions (ADRs). It was found that a significant proportion of XDR-TB patients are HIV unrelated, and prognosis, regardless of HIV status, poor. Nevertheless, survival in HIV infected patients is better than previously reported, and …
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An Expandable Stage-Based Machine Learning and Statistical Pipeline for Detecting Adverse Drug Reaction Risks on Complex Multidimensional Datasets
Adverse Drug Reactions (ADRs) are a persistent challenge to patient safety, often escaping detection in aggregate analyses. This research introduces expandable, modular pipeline that identifies statistically significant drug–ADR associations through a multivariable, propensity-adjusted framework …
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Drug prescribing and administration changes in hospitalized geriatric patients : analysis of three drug utilization review programs
… patients or 0.5% of the population. The use of drugs in this population comprises approximately 25% of the prescription drug market in the United States which is directly related to the greater occurrence of pathological problems associated with the aging process. While it is evident that the …
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Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином
… several medications often increases the risk of adverse reactions and can compromise the treatment. Because of this, the identification and assessment of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs …
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