Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"Advanced glycation end-products"”.
-
The relationship between dietary advanced glycation end products and diabetes related complications
… the accumulation of a group of compounds called advanced glycation end products (AGEs). AGEs can be formed in the body and contribute to vascular damage in diabetes. In addition, AGEs can be found in some foods rich in protein and fat (high cooking temperatures increases its formation) and some …
-
Advanced glycation end products as a biomarker for accelerated ocular ageing and glaucoma
Advanced glycation end products (AGEs) have a large impact on the healthy ageing population and those diagnosed with pathology. Studies have linked AGEs to glaucomatous optic neuropathy, however there is little consensus on the role AGEs play in glaucoma development. Furthermore, it is known that …
-
Involvement of The Receptor For Advanced Glycation End Products (Rage) In Progression of Pancreatic Cancer
… the mechanisms by which, the receptor for advanced glycation end products (RAGE) affects and maintains <em>KRAS </em>activity. We observed that RAGE levels were elevated and there was a shift in the levels of specific isoforms upon inflammation in pancreatic cells and PDAC. Furthermore, …
-
Targeting the receptor for advanced glycation end products with a quantitative multimodal imaging method for precision medicine
The Receptor for Advanced Glycation End Products (RAGE) has been shown to contribute to a myriad of pathologies including nephropathy, Alzheimer’s disease, cardiomyopathy, and pulmonary, ocular, arterial, and atherosclerotic diseases. It has been shown that RAGE expression levels are high during …
-
Thiol Dough Conditioners Impact on the Formation of Advanced Glycation End-products in Bagels Containing Sunflower Seed Flour
<p>Baking bagels can increase advanced glycation end products (AGEs), which are linked to increased metabolic and chronic diseases. This research correlated color and the proximate composition with fluorescent AGEs in bagels containing 0-20% sunflower flour (SFF) and 0-90 ppm L-cysteine (Cys) or …
-
The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… of DNA and protein promoting the formation of advanced glycation end products (AGEs). The formation and accumulation of AGEs in different cell types affect intracellular and extracellular structure and function. AGEs can also cause macrovascular and microvascular complications through the …
-
Chlorogenic and Caffeic Acids’ Impact on Formation of Fluorescent and Non-Fluorescent Advanced Glycation End-Products as a Function of Temperature
<p>The glycation of amino acids with carbonyl groups of reducing sugars produces advanced glycation end-products (AGEs). These AGEs can be harmful to health over time. The research objective was to compare the effects of 0-1.00 mM chlorogenic acid (CGA) and caffeic acid (CA) on AGEs formed in …
-
Η συσχέτιση μεταξύ των προϊόντων τελικής γλυκοζυλίωσης και του οξειδωτικού στρες σε άτομα με προδιαβήτη
… παραγωγή τελικών προϊόντων γλυκοζυλίωσης (Advanced Glycation End Products - AGEs) και οξειδωτικό στρες, δύο παράγοντες που εμπλέκονται στην παθογένεση των μικροαγγειακών βλαβών και την εξέλιξη της νόσου. Σκοπός της παρούσας πιλοτικής μελέτης είναι η μελέτη των AGEs και του οξειδωτικού στρες …
-
Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans
… cause of these diseases is the accumulation of advanced glycation end products (AGEs), which are macromolecules that cause irreversible damages. AGEs are a diverse group of highly oxidative byproducts produced from α-dicarbonyl compounds (α-dcs), which are highly reactive molecules that bind …
-
Diet, Adiposity, and Advanced Glycation Endproducts
… which may affect the serum soluble receptor for advanced glycation end products (sRAGE) and to determine whether macronutrient diet composition impacts inflammation and levels of serum n-epsilon-carboxymethyl-lysine (CML), a measure of advanced glycation endproducts. In study I, we tested the …
-
Combinational Therapy to Mitigate α-Dicarbonyl Toxicity
… methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and cardiomyopathy. A recently discovered TRPA-1-Nrf-2 pathway is …
-
Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… At the cellular level, dysfunction of vascular endothelial cells is often associated with diabetic conditions. Multiple agents maintain the endothelium, including vascular endothelial growth factor (VEGF), an endothelial cell mitogen/survival factor, and insulin, which has anti-apoptotic effects …
-
GENETIC AND BIOCHEMICAL ANALYSIS OF TYPE 2 DIABETES AND DIABETIC COMPLICATIONS
… cardiovascular disease (CVD), nephropathy or end-stage kidney disease (ESKD), and cognitive decline. CVD is the most common complication with up to 65% of individuals with T2D dying due to CVD. Individuals with T2D are 2 – 4 times more likely to die due to CVD causes than those without T2D. …
-
Part I: Design, synthesis, and studies of novel age-inhibitors and age-breakers; Part II: Novel synthetic methods for organofluorine compound
… small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their <em>in vitro</em> inhibitory activities have been studied by <sup>13</sup>C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and …
-
Oxidative Stress and Inflammation in the Heterogeneity of Metabolic Health
… by complex biological processes that extend beyond anthropometric indicators such as body mass index (BMI). Chronic low-grade inflammation and oxidative stress are key mechanisms linking metabolic dysfunction to cardiometabolic disease, but their interaction across metabolic health …
-
Fructose and the Maillard reaction
… reaction, specifically the development of Advanced Glycation End-products (AGEs) in vivo, is linked to the pathogenesis of diabetic secondary complications. The same diseases that occur in old age are similarly thought to develop as a function of the accumulation of AGEs. This thesis …
-
Influence of infant milk formula processing on protein digestion and gut barrier health in vitro and in vivo
… the Maillard reaction, with the generation of advanced glycation end products. Denatured and aggregated dairy proteins will be digested differently in the infant gut compared to native dairy proteins. The degree of glycation will also alter digestion. Employing lower temperatures or non-thermal …
-
Μελέτη των τελικών προϊόντων προηγμένης γλυκοζυλίωσης (AGEs) σε άτομα με σακχαρώδη διαβήτη τύπου 2 μικρής διάρκειας με επιπλοκές
… τελικών προϊόντων προηγμένης γλυκοζυλίωσης (Advanced Glycation End-products, AGEs), μηχανισμοί που συμβάλλουν καθοριστικά στην παθογένεση μικροαγγειακών και μακροαγγειακών επιπλοκών. Σκοπός: Η διερεύνηση των επιπέδων AGEs και δεικτών οξειδωτικού στρες σε άτομα με ΣΔτ2 διαφορετικής διάρκειας, …
Page 1 of 2