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Showing 1 to 17 of 17 for “"Advanced glycation end products (AGEs)"”.
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… of DNA and protein promoting the formation of advanced glycation end products (AGEs). The formation and accumulation of AGEs in different cell types affect intracellular and extracellular structure and function. AGEs can also cause macrovascular and microvascular complications through the …
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Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans
… cause of these diseases is the accumulation of advanced glycation end products (AGEs), which are macromolecules that cause irreversible damages. AGEs are a diverse group of highly oxidative byproducts produced from α-dicarbonyl compounds (α-dcs), which are highly reactive molecules that bind …
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Combinational Therapy to Mitigate α-Dicarbonyl Toxicity
… methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and cardiomyopathy. A recently discovered TRPA-1-Nrf-2 pathway is …
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Targeting the receptor for advanced glycation end products with a quantitative multimodal imaging method for precision medicine
The Receptor for Advanced Glycation End Products (RAGE) has been shown to contribute to a myriad of pathologies including nephropathy, Alzheimer’s disease, cardiomyopathy, and pulmonary, ocular, arterial, and atherosclerotic diseases. It has been shown that RAGE expression levels are high during …
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Part I: Design, synthesis, and studies of novel age-inhibitors and age-breakers; Part II: Novel synthetic methods for organofluorine compound
… small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their <em>in vitro</em> inhibitory activities have been studied by <sup>13</sup>C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and …
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Fructose and the Maillard reaction
… reaction, specifically the development of Advanced Glycation End-products (AGEs) in vivo, is linked to the pathogenesis of diabetic secondary complications. The same diseases that occur in old age are similarly thought to develop as a function of the accumulation of AGEs. This thesis …
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Chlorogenic and Caffeic Acids’ Impact on Formation of Fluorescent and Non-Fluorescent Advanced Glycation End-Products as a Function of Temperature
<p>The glycation of amino acids with carbonyl groups of reducing sugars produces advanced glycation end-products (AGEs). These AGEs can be harmful to health over time. The research objective was to compare the effects of 0-1.00 mM chlorogenic acid (CGA) and caffeic acid (CA) on AGEs formed in …
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Η συσχέτιση μεταξύ των προϊόντων τελικής γλυκοζυλίωσης και του οξειδωτικού στρες σε άτομα με προδιαβήτη
… παραγωγή τελικών προϊόντων γλυκοζυλίωσης (Advanced Glycation End Products - AGEs) και οξειδωτικό στρες, δύο παράγοντες που εμπλέκονται στην παθογένεση των μικροαγγειακών βλαβών και την εξέλιξη της νόσου. Σκοπός της παρούσας πιλοτικής μελέτης είναι η μελέτη των AGEs και του οξειδωτικού στρες …
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The relationship between dietary advanced glycation end products and diabetes related complications
… the accumulation of a group of compounds called advanced glycation end products (AGEs). AGEs can be formed in the body and contribute to vascular damage in diabetes. In addition, AGEs can be found in some foods rich in protein and fat (high cooking temperatures increases its formation) and some …
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Advanced glycation end products as a biomarker for accelerated ocular ageing and glaucoma
Advanced glycation end products (AGEs) have a large impact on the healthy ageing population and those diagnosed with pathology. Studies have linked AGEs to glaucomatous optic neuropathy, however there is little consensus on the role AGEs play in glaucoma development. Furthermore, it is known that …
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Μελέτη των τελικών προϊόντων προηγμένης γλυκοζυλίωσης (AGEs) σε άτομα με σακχαρώδη διαβήτη τύπου 2 μικρής διάρκειας με επιπλοκές
… τελικών προϊόντων προηγμένης γλυκοζυλίωσης (Advanced Glycation End-products, AGEs), μηχανισμοί που συμβάλλουν καθοριστικά στην παθογένεση μικροαγγειακών και μακροαγγειακών επιπλοκών. Σκοπός: Η διερεύνηση των επιπέδων AGEs και δεικτών οξειδωτικού στρες σε άτομα με ΣΔτ2 διαφορετικής διάρκειας, …
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Thiol Dough Conditioners Impact on the Formation of Advanced Glycation End-products in Bagels Containing Sunflower Seed Flour
<p>Baking bagels can increase advanced glycation end products (AGEs), which are linked to increased metabolic and chronic diseases. This research correlated color and the proximate composition with fluorescent AGEs in bagels containing 0-20% sunflower flour (SFF) and 0-90 ppm L-cysteine (Cys) or …
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Diabetes Mellitus and Limited Joint Mobility in the Upper Extremity
… tissue due to non-enzymatic accumulation of advanced glycation end-products (AGEs), and resultant cross-link formation in the collagen. Specific implications of these structural changes on movement in people with DM are not known. The objectives of this research were to characterize the upper …
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Endocrine, cellular and molecular effects of diabetes mellitus on male fertility
… evaluate the effects of diabetes on functional, endocrine, cellular and molecular aspects of male reproduction.<br/><br/>Sexual function, assessed using a validated multi-dimensional questionnaire, and the reproductive endocrine axis were compared in diabetic and nondiabetic subjects. This study …
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Protective effects of regular exercise and Korea red ginseng against high-fat diet-increased renal injury in ᴅ-galactose-induced aging rats
… is progressive accumulation of oxidative agents. Advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) formation has been implicated in the aging process. Obesity induced by a high-fat diet (HFD) may reduce renal function. However, the impact of obese on the …
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Defining the molecular, genetic and transcriptomic mechanisms underlying the variation in glycation gap between individuals
… been observed and is referred to as the glycation gap (G-gap). This could be explained by the higher activity of the fructosamine-3-kinase (FN3K) deglycating enzyme in the negative G-gap group (patients with lower than predicted HbA1c for their mean glycaemia) as compared to the positive …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… and fluorescent compounds, termed "Maillard products" or advanced glycation end products (AGEs). AGE formation has been observed on long-lived proteins such as collagen, eye lens crystalline, and in pathological protein deposits in Alzheimer's (AD) and Parkinson's disease (PD) and …