Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Advanced Pancreatic Cancer"”.
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The Effects of Curcumin On Body Composition of Patients With Advanced Pancreatic Cancer
<p>Cachexia is very common among patients with advanced pancreatic cancer and is a marker of poor prognosis. Weight loss in cachexia is due to both adipose and muscle compartments, and sarcopenia (severe muscle depletion) is associated with worse outcomes. Curcumin has shown a myriad of biological …
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The experience and communication of symptoms in advanced pancreatic cancer patients and their families
… the main focus of care for patients living with advanced pancreatic cancer (APC). However, evidence shows that symptom management is far from satisfactory for this population. Poorly managed symptoms have had a profound negative impact on APC patients’ and caregivers’ life. While communicating …
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Prognostic Significance of Xct Polymorphisms and Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy
… glutamate and is highly expressed by pancreatic cancer cells. The <em>xCT</em> gene, encoding the cystine-specific xCT protein subunit of x<sub>c</sub><sup>-</sup>, is important in regulating intracellular glutathione (GSH) levels, critical for cancer cell protection against oxidative …
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Informed Decision Making for Patients with Advanced Pancreatic Cancer Considering Chemotherapy: Development and Evaluation of a Clinical Decision Aid for Patients
Pancreatic cancer is the fourth leading cause of cancer death in Canada. Significant advancements in chemotherapy for advanced pancreatic cancer have resulted in the need for a quantitative comparison between these treatments on a relative scale. Therefore, a systematic review and Bayesian network …
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Design, development, and evaluation of a web-based information tool to support decisions on treatment options for people with advanced pancreatic cancer: A mixed-methods study.
… is complex, especially for people diagnosed with advanced pancreatic cancer (APC), because of the associated low incidence and high mortality rates of the disease compared to other cancers. APC is incurable, and patients usually receive palliative systemic anticancer treatment (SACT). …
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Proteasome Inhibition Enhances The Effect of Bikdd Gene Therapy
… amplifier) system under the control of a cancer specific promoter, previous studies have verified the specific killing effect of BikDD in cancer cells both in <em>in vitro</em> and <em>in vivo</em> models. C-VISA-BikDD delivered by liposome has been approved by FDA for clinical trial in …
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Statistical modelling for the prognostic classification of patients with pancreatic cancer for optimisation of treatment allocation
Pancreatic cancer is a common cause of cancer death and is difficult to diagnose and treat. A prognostic index can be used in clinical practice to predict survival. Thirty six prognostic factor studies were identified but size and statistical methods were inappropriate. Continuous variables are …
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Development and In-Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma
Pancreatic cancer is a solid malignancy which is one of the leading cause of cancer related deaths in the United States of America. While recent therapeutic advances for patients with advanced pancreatic cancer have shown some potential, but prognosis remains grim with the 5-year survival is much …
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Analyzing the Effect of Neoadjuvant Stereotactic Ablative Body Radiotherapy on Pancreatic Tumour Perfusion Using Computed Tomography Perfusion
… is currently the primary curative treatment for pancreatic ductal adenocarcinoma (PDAC). However, surgery is only feasible for patients who have resectable pancreatic cancer (RPC), which is nonmetastatic, well-localized, and has minimal involvement of the critical vessel structures around the …
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Repurposing itraconazole as a novel and promising therapeutic strategy for pancreatic cancer
Pancreatic cancer has the highest mortality rate among all main cancer types and is the 3rd leading cause of cancer death in Australia. Standard chemotherapy for advanced pancreatic cancer only imparts a modest clinical benefit as the overall 5-year survival of all stages of the disease remains …
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Application of pharmaceutical technologies to improve the activity of cancer chemotherapeutic agents
Cancer is a leading cause of death worldwide. Chemotherapy remains a major therapeutic modality in cancer treatment. Conventional chemotherapeutic agents usually have limited efficacy. Furthermore, chemotherapeutic agent- and/or excipient-related toxicities comprise a serious problem that may, in …