Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Adult neurogenesis"”.
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The Role of Adult Neurogenesis in Cocaine Addiction
New neurons are born in the adult hippocampus in a region known as the subgranular zone (SGZ). This process is dynamically regulated and new neurons are thought to be important for certain types of spatial learning and memory. Proliferation of SGZ neural progenitors is decreased by drugs of abuse, …
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
Neurogenesis in the adult brain is a complex and lifelong process that is regulated by multiple pathways and is sensitive to many external stimuli. Two critical regulatory factors in this process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and …
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Cadmium exposure impairs adult neurogenesis, cognition, and olfactory memory in mice
… olfactory functions. In this study, by exposing adult male mice to 3 mg/L Cd through drinking water, I found that Cd exposure induces persistent impairments of hippocampus-dependent learning and memory in the novel object location test, the T-maze test, and the contextual fear memory test, but …
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Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
… this work we investigated the role of mAChRs in adult neurogenesis and further clarified the regulation of muscarinic agonist-induced seizures. We first investigated the role of mAChRs in adult neurogenesis in the subventricular zone (SVZ) and the subgranular zone (SGZ). We were unable to detect …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
While compensatory striatal neurogenesis is well documented in many injury models, cells of the correct lineage for endogenous repair are not always regenerated. To understand why, the molecular profile of subventricular zone (SVZ)-derived neural progenitor cells (NPCs), and their response to …
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Determinants of cns adult neurogenesis are sex, hormones, mouse strain, age, and brain region
… indicate testosterone is a major regulator of adult neural proliferation. At 6-8mo, the ratio of PDGFRa+ cells in the CC to BrdU+ cells in the DLC of both strains, sexes, estrous cycle and castrated mice was essentially the same, suggesting BrdU+ cells in the DLC differentiate into CC …
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Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse
Neurogenesis is the process of generation of neurons during embryonic development and adulthood. The focus of this doctoral work is the study of the cell biological aspects of neurogenesis and the mechanisms regulating the switch of neural stem cells from proliferation to differentiation. During …
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Manganese Toxicity: Accumulation in Bone, Effect on Brain Neurochemistry, and Impact on Adult Neurogenesis
… in Bone, Effect on Neurochemistry, Impact on Adult Neurogenesis. Major Professor: Wei Zheng.
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A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells
<p>Neurogenesis persists in restricted regions of the adult vertebrate brain. The largest region of adult neurogenesis is the subventricular zone (SVZ) of the lateral ventricle wall. Neural stem cells reside in the SVZ. The SVZ cell types and molecular signals necessary for this neurogenic niche …
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ANALYSIS OF ADULT NEUROGENESIS AND HIPPOCAMPUS-DEPENDENT MEMORY IN MOUSE MODELS FOR AGING, ALZHEIMER’S DISEASE AND CRANIAL IRRADIATION-INDUCED NEUROINFLAMMATION
… The hippocampus is one of the few areas in the adult brain where new neurons are continuously produced throughout life. Furthermore, hippocampal neurogenesis has been shown to support neighboring neurons and correlate with hippocampal learning and memory performance. However, it is unknown how …
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
Adult neurogenesis is a life-long developmental process occurring in two discrete regions in the adult mammalian brain, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) along the lateral ventricles. External stimuli including environmental enrichment activities and …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… the past decade, growing evidence indicates that adult neurogenesis (the production of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative and psychiatric disorders. Studies have shown that neurogenesis is clearly a …
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
… new neurons throughout life. This process of adult neurogenesis has been thoroughly documented in several species including birds, rodents and humans. Adult neurogenesis is not a global process, but is confined to two subcompartments of the brain; the subventricular zone lining the lateral …
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Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability
… is by now an accepted fact, the function of adult-generated neurons still largely remains a mystery. The ability of new neurons to form synapses with preexisting neurons without disrupting circuit function is central to the hypothesized role of adult neurogenesis as a substrate for learning …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… form a neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… form a neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG …
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Neurogenesis Dependent Learning And Implications For Episodic Memory In Rodent Models.
… hippocampus as it relates to episodic memory, neurogenesis, and their potential functional intersection. Chapter 2 presents a novel model for episodic-like memory in rats, and relates it to previous models and its potential application for human episodic memory. In chapter 3, we present …
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Investigation of RNA-Binding Protein Expression Changes in the Hippocampus Following Doxorubicin and Cyclophosphamide Treatment
… pronounced vulnerability in regions critical for adult neurogenesis and memory processing, thereby providing molecular targets for developing neuroprotective strategies to mitigate cognitive impairment in cancer patients undergoing chemotherapy.<strong></strong></p>
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HIV-1 INFECTION OF NEURAL STEM CELLS RESULTS IN COGNITIVE DEFICITS THROUGH ADULT NEUROGENIC MODULATION
… neurocognitive impairments through dysregulating adult neurogenesis. Adult neurogenesis is a dynamic process that describes the generation of new neurons and glial cells from NSCs and neural progenitor cells (NPCs). This process mainly takes place in two areas of the brain: the SVZ around the …
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Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus
… spatial memory and navigation and also exhibits adult neurogenesis. In wild-living species, HPC volume and neurogenesis have been found to differ between the sexes and vary seasonally in tandem with spatial behaviours such as food-caching and mating. However, few studies have simultaneously …
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