Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Adult bone marrow"”.
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Psycho-social problems identified by adult bone marrow transplant survivors
Bone marrow transplantation (BMT) offers many patients who are diagnosed with leukaemia, lymphoma, myeloma and aplastic anaemia the opportunity of increased survival. Chemotherapy is one of the most common forms of treatment for cancer patients en-route to BMT, which is often a concomitant stressor …
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Isolation of Mesenchymal Stem Cells Derived from Adult Bone Marrow and Umbilical Cord Blood and Their Potential to Differentiate into Osteoblasts
… system. Despite major strides in the field of bone regenerative medicine during the years, current therapies, such as bone grafts, still have several limitations. Multipotent stem cells, such as mesenchymal stem cells (MSCs) are promising candidates for tissue repair because of their …
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
… damaged tissues may be a realistic alternative. Adult bone marrow derived mesenchymal stem cells are undifferentiated, multipotent cells that have the ability to differentiate into the chondrocyte-like cells found within the nucleus pulposus of the adult intervertebral disc. This study examines …
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity
… that assesses the genotoxic effect of drugs on adult bone marrow (BM) using the metric of genotoxic damage to the reticulocyte population in mice. An in vitro correlate to this assay might facilitate extension to human cells and thus provide a highly predictive genotoxicity assay. As first steps …
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Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
Mesenchymal stem cells, harvested from adult bone marrow, are promising in the field of regenerative medicine because of the vast differentiation potential into various cell lines such as: osteoblasts, chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells …
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An in vitro evaluation of tyrosine derived polyarylates and polycarbonate as polymeric scaffold for human mesenchymal stem cells osteogenic differentiation
… mesenchymal stem cells (hMSCs) obtained from the adult bone marrow are multipotential cells that are capable of differentiating along several lineages. They are readily available and abundant source of cells in the field of tissue engineering. For their use in treating certain connective tissue …
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Biology of adult human normal and leukaemia CD133+ stem cells
… investigated the neural differentiation of human adult bone marrow and foetal liver CD133+ stem cells; explored the presence of CD133 and embryonic stem cell marker Oct-4 positive stem cells in adult human normal and malignant tissues, including normal brain tissues, normal and malignant bone …
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
… The work presented here demonstrated that adult bone marrow-derived allogeneic MSC actively prevent the induction of allergen driven pathology in a murine model. Prior stimulation of MSC with IFN-γ increased their protective effect. An increase in IL-10 as a result of MSC delivery suggested …
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Soluble factors and remodeling in a synthetic stem cell niche
… daily, this rare population (<0.01% of human bone marrow) possess the ability to produce multiple cell lines (differentiation) and stem cell daughters (self-renewal). HSCs are found throughout the body but primarily reside in the adult bone marrow, in specialized compartments termed the niche. …
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Vergleich der Differenzierungspotentiale humaner mesenchymaler Stammzellen aus dem Knochenmark und aus der Nabelschnur auf kollagenen Matrices
… as well as the functional behaviour of human bone marrow- and umbilical cord mesenchymal stem cells on three dimensional collagen scaffolds during osteogenic induction. We could draw conclusions from the in vitro characteristics of the stem cell-biomaterial-hybrids as to the in vivo …
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Deciphering the Mechanisms of Heterogeneity within Haematopoiesis in Health, Development & Disease
… such as how HSCs interconvert in murine and adult bone marrow during homeostasis, as well as how HSC dormancy and activity signatures show dynamic changes during fetal/post-natal development and are dysregulated by the pre-leukaemic mutation Jak2 V617F. Moreover, this work reveals that …
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REGULATION OF Fas-MEDIATED APOPTOSIS BY THE Fas ANTI-SENSE NON-CODING RNA "Saf"
… from fetal liver (FL), cord blood (CB), or adult bone marrow (BM) to screen 82 documented lncRNAs. This screen revealed that the Fas Anti-sense (Saf) was consistently increased during maturation and levels high for BM compared to FL or CB. Next, I characterized the regulatory sequence of Saf …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… yolk sac, embryonic and fetal liver, and bone marrow), newborn (cord blood), paediatric (bone marrow), as well as adult (bone marrow and spleen). Our prenatal and neonatal analysis revealed unique surface protein profiles and differentiation biases already present in the prenatal tissues. …
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Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
… speculated to be more primitive in comparison to adult stem cells. However the limited amount of HSCs is limiting their application for stem cell therapy in clinic. Therefore, people started to utilize extra-embryonic tissue to harvest more fetal stem cells, while people also tried to optimize the …
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Clonal Studies of Human B Cells
… I studied B-cell development in both fetal and adult tissues.</p><p>In human fetal liver, most CD19+ cells co-express CD10, a marker of human developing B cells. Some CD19+CD10+ B cells express CD27, and these fetal CD27+ cells are present in the pro-B, pre-B, and immature/transitional B-cell …