Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Adult Stem Cells"”.
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Adipose-Derived Adult Stem Cells as Trophic Mediators of Tendon Regeneration
… tendonitis. This heterogeneous population of cells may improve tendon healing via the production of growth and chemotactic factors capable of recruiting endogenous stem cells and increasing extracellular matrix production by tendon fibroblasts (TFBL). The purpose of this study was to evaluate …
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An insulin-like peptide regulates size and adult stem cells in planarians
… status is uncoupled from moderation of adult stature after adult size is achieved. However, some long-lived animals continue to regulate adult size and fertility in a nutrition-dependent manner. For example, the regenerating flatworm Schmidtea mediterranea becomes smaller, or degrows, …
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Application and Development of Advanced Genetic Tools to Study Adult Stem Cells
… Development of Advanced Genetic Tools to Study Adult Stem Cells By: Amanda Andersson Rolf In adult mammals, the gastrointestinal (GI) epithelium exhibits the highest turnover rate among the endodermal tissues. The harsh luminal environment of the GI tract necessitates replenishment of epithelial …
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The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
… to investigate the therapeutic efficacy of adult, adipose derived stem cells (ADSC). The paralyzed mice that received ADSC transplantation demonstrated significantly improved motor function, likely due to stromal support provided by ADSCs. The ultrastructure of the nerve was not …
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The detection of immortal DNA strand co-segregation as a method of adult stem cell identification
The study of stem cells is one of the most fascinating topics in biology. Adult stem cells (ASC), which play the prime role in the maintenance and restoration of tissues, are thought to hold great potential for the advancement of medicine. It has been postulated that adult stem cells are able to …
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Investigation of growth factors and cytokines that suppress adult stem cell asymmetric cell kinetics
Adult stem cells are potentially useful in many biomedical applications that can save lives and increase the quality of a patient's life, such as tissue engineering, cell replacement, and gene therapy. However, these applications are limited because of the difficulty in isolating and expanding pure …
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Genetic regulation of neuronal stem cell differentiation: a single-cell sequencing study in planarians
… is incredibly prominent in the nervous system, where even in a single brain region, individual neurons may differ deeply in their molecular, anatomical, and functional features. Platyhelminthes like Schmidtea mediterranea continuously turn over all their tissues, including the brain, and …
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
<p>Adult stem cells are endowed with the remarkable ability to maintain, regenerate and repair tissues throughout the lifetime of the organism. Whether parsimonious utilization of adult stem cells is necessary to preserve their long-term potential has not been fully explored. I investigated this …
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Transcriptional regulators in stem cell biology
Adult stem cells support tissue regeneration by both self-renewing and differentiating into specialized cell types. Analogous self-renewal and differentiation processes enable cancer stem cells to promote tumorigenesis. Transcriptional modulation, enacted by proteins including epigenetic regulators …
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Investigating Adult Stem Cell Lineage Specification in the Freshwater Flatworm Schmidtea mediterranea
Adult stem cells (ASCs) serve to facilitate tissue turnover during the lifespan of an organism. The goal of my research has been to deepen our understanding of how ASCs become specified towards differentiation to produce physiologically functional cell types. To this end, I have chosen to use the …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
Adult stem cells become less efficient at maintaining tissue integrity and repairing tissue damage with age. Oligodendrocyte progenitor cells (OPCs) are the largest population of stem cells in the adult CNS and give rise to oligodendrocytes. OPCs play a critical role in myelin regeneration …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
<p>Adult stem cells reside in niches, which control their long-term ability to selfrenew and produce the differentiated cell lineages necessary to regenerate and repair their tissues. Following injury, culture or transplantation, stem cells outside their niche often acquire broader plasticity in …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
Human mesenchymal stem cell (hMSC) is an attractive source of adult stem cells for the therapeutic use in regenerative medicine. These cells are usually culture expanded prior to their application. However, their proliferation and differentiation potential were gradually decreased during in vitro …
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Self-renewal pattern-associated genes and their role in adult stem cell functions
Molecular markers for adult stem cells (ASCs) are highly demanded for research and clinical applications. The development of specific molecular markers for ASCs has been difficult mainly due to the technical barriers in the identification and isolation of rare ASCs. Previously, reported …
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Investigation of a suppression of asymmetric cell kinetics (SACK) approach for ex vivo expansion of human hematopoietic stem cells
Ex vivo expansion of hematopoietic stem cells (HSCs) is a long-standing challenge faced by both researchers and clinicians. To date, no robust, efficient method for the pure, ex vivo expansion of human HSCs has been demonstrated. Previous methods primarily induced the expansion of committed …
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Optimization of culture conditions for equine bone marrow mesenchymal stem cells and their differentiation into osteoblasts
… advancements in research, including the use of adult stem cells; specifically, mesenchymal stem cells (MSC), in fracture healing. The main focus of previous research in this area has been in rodent and human models. The previous research has shown that MSC are an accessible and functional source …
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Physicochemical characterization of immortal strand DNA
Adult tissue differentiation involves the generation of distinct cell types from adult stem cells (ASCs). Current understanding of tissue differentiation mechanisms is based on studies of protein and RNAs that asymmetrically segregate between daughter cells during embryogenesis. Whether or not …
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Isolation, characterization, and functional assessment of novel smooth muscle like stem progenitors
Vascular smooth muscle cells (VSMC) are one of the key players in the pathogenesis of cardiovascular diseases. The origin of neointimal VSMC has thus become a prime focus of research. VSMC originate from multiple progenitors cell types. In embryo the well-defined sources of VSMC include; neural …
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Investigating The In Vivo Role Of Wnt Acylation
… in embryonic patterning, the maintenance of adult stem cells, and the evolution of cancers. Mammalian genomes contain 19 unique Wnt proteins which undergo post-translational acylation at a highly-conserved serine residue. All Wnts bind to the Frizzled (Fz) family of seven-pass transmembrane …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… recognized and attacked by the host immune system while the PNF is characterized as the loss of islet viability and function caused by non-immune reasons, such as the disruption of islet microvasculature during islet isolation and purification process, hypoxia in the core of islet grafts and …
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