Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Adult Offspring"”.
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Intergenerational dynamics of adult offspring living in the parental home
… was to contribute to a base of information about adult offspring who reside in the parental home, with particular emphasis on intergenerational relationships. The variables investigated included intimacy with parents, individuation from family of origin, triangulation, intimidation, and personal …
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The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… nutrient supply and growth can programme the offspring to develop altered metabolic health in later life. Despite this, little is known about the role of the endocrine placenta in fetal nutrient supply, growth and the programming of adult metabolism. To study this, we conditionally disrupted …
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Prenatal exposure to maternal obesity and SFLT-1 overexpression and cardiovascular function in the adult offspring
… the leading cause of death in the United States. Adult smoking, type II diabetes, and other environments and conditions, have been identified as risk factors for cardiovascular diseases; however, the effects of prenatal development cannot be overlooked. In the 1980s Barker proposed a hypothesis …
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Prenatal PolyI:C induced schizophrenia-like cognitive inflexibilities in the male, but not female, rat adult offspring
… risk to develop psychiatric disorders in the adult offspring. One study found that schizophrenic patients pre-exposed to a prenatal infection perseverated more during the WCST, than non-pre-exposed patients. Despite these findings, there are still numerous limitations (e.g., ethical concerns) …
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The Impact of Maternal Methyl-Donor Nutrient Supplementation on Vitamin D Status and Inflammation among Adult Offspring
… lactation on VD status and inflammation among offspring. Our results suggest a critical role of prenatal MS in mediating VD status among offspring and suppressing systemic inflammation in offspring. We further demonstrated that prenatal and postnatal diets differentially regulate renal and …
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The Role of Maternal High Fat Diet in the Pathogenesis of Metabolic and Bone Disease in the Adult Offspring
… with an increased risk of chronic diseases in adult life. The studies presented in this dissertation sought to exploit this phenomenon to determine the extent to which gestational and lactational exposure to a high fat diet predisposes the offspring to certain diseases in later life and if the …
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A Model of the Relationship of Perceived Mental and Emotional Problems in the Family-of-Origin on Marital Satisfaction of Adult Offspring
… (psychopathology) in the family-of-origin on adult offspring marital satisfaction was tested in a model considering the mediating variables of parental marital satisfaction, mother-child relationship quality, father-child relationship quality, and resolution of issues from the …
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A maternal high fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats
… of developing metabolism-related diseases in adult offspring, including chronic liver disease. The present study tested the hypothesis that maternal high fat diet leads to a decreased antioxidant defense capacity and causes cellular senescence in liver of adult offspring rats, which might …
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The Developmental Timing of Divorce and Adult Children's Romantic Relationship Quality
… has positive or negative long-term effects for adult children is at the heart of this study. Although previous studies suggest an association between parental divorce and the divorce of adult offspring, less known is about whether the timing of divorce influences the relationship outcomes of …
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The effects of leptin on placental development and function, and offspring behavior in mice
… the effect of maternal hyperleptinemia on offspring behavior. We compared wildtype offspring from two hyperleptinemic mouse models. Adult offspring from hyperleptinemic dams weighed less, and were more active than their controls. Female offspring from these dams consumed more food and had …
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Effect of a maternal inflammatory challenge during the preimplantation period on offspring development and phenotype
… metabolic and behavioural abnormalities in the adult offspring.<br/>Do other types of maternal challenge similarly impact on the developmental programme with long-lasting consequences? Infection and injury are common in everyday life and normally result in altered homeostasis and generation of …
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Where do all the spoons go? : perceptions of parents of adult heroin users
… for parents when their problematic drug using adult offspring were mandated into drug treatment programmes in the community, and when their offspring engaged with treatment in the prison setting. In addition, this research aims to develop an understanding about whether or not these types of …
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Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring
… induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet and reversed by neonatal leptin treatment. Evidence is now accumulating which indicates that …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… with the development of schizophrenia in adult offspring. Epidemiological evidence indicates that elevated maternal levels of the chemokine interleukin- 8 (IL-8) during MIA contribute to the neurodevelopmental alterations underlying the disorder. The present experiments used an animal …
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Prenatal stress alters fear-conditioned behaviors and the response to serotonergic drugs
… prenatal stress) modifies the behavior of the adult offspring. Several behaviors were evaluated in adult prenatally stressed (PS) rats, most notably the acoustic startle response and behavioral inhibition (i.e. freezing). PS rats do not differ in baseline peak startle responding, or in the …
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Prenatal dexamethasone exposure: glucocrticoid programming of the brain
… of developing neuropsychiatric disorders in adulthood. This phenomenon has been studied and known as ‘fetal programming of adult diseases’. According to the theory, environmental insults occurring at critical periods of pregnancy can permanently alter the structure and physiology of the …
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Long-term impacts of antenatal corticosteroid exposure and preterm birth
… to antenatal betamethasone. We followed up the adult offspring of participants in this trial using a health questionnaire and routinely collected data. Of 1,218 infants born to 1,115 women, 424 participants were included at mean age 49.3 years (46% of survivors). Forty-six participants deceased …
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ROLE OF STRESS EARLY IN LIFE AND OF INFLAMMATION IN THE RISK TO DEVELOP DEPRESSION LATER IN LIFE
… vulnerability to psychiatric disorders in the offspring. Specifically, I focused on maternal inflammation, placental immune signaling, and long-term neuroimmune outcomes. Using a multi-level approach that integrates behavioral, molecular, immunological, and transcriptomic analyses, I …
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Moderate Ethanol Consumption by the Pregnant Guinea Pig Increases Ethanol Preference in Offspring
… functional deficits in the fetus and postnatal offspring. The objective of this thesis was to test the hypotheses that moderate CPEE produces in postnatal offspring: (i) structural and functional teratogenic effects; (ii) increased ethanol preference; (iii) altered responsiveness to acute …
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Three Essays on Social Stratification, Gender and Health
… relationship between mortality of parents and offspring's educational attainment, and the association between adult literacy and self-rated health in 17 developed countries. Methodologically, I use multinomial regression, quantile regression, Cox proportional hazards models, and country …
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