Global ETD Search
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Showing 1 to 7 of 7 for “"Adrenocortical carcinoma"”.
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CARCINOMA CORTICAL DA ADRENAL NÃO FUNCIONAL COM INVASÃO DA VEIA CAVA CAUDAL EM CÃO
… neoplasms, which the benign adenoma and malign carcinoma are the most found between adrenal gland tumors. The present work aims to describe the case of a dog diagnosed with carcinoma in the cortex of the adrenal gland with invasion of caudal vena cava. A male dog with 15 kg, mixed breed was …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
… mRNA by post-transcriptional mechanisms in human adrenocortical carcinoma cell line (H295R cells). Protein kinase C (PKC) activator, phorbol-12-myristate-13-acetate (PMA), showed that the downregulation of hAT1R mRNA is mediated by the PKC pathway. Experiments performed in the presence of …
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The use of whole exome sequencing data to identify candidate genes involved in cancer and benign tumour predisposition
… ii) sweat duct proliferation tumours, iii) adrenocortical carcinoma, and iv) breast cancer. Each set underwent germline whole exome sequencing followed by additional tumour or targeted sequencing to identify associated predisposition genes. Variants within a cluster of risk genes that are …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
Adrenocortical tumours (ACT) are a highly heterogeneous class of endocrine cancers, ranging from the common adrenocortical adenoma (ACA) to the rare and aggressive adrenocortical carcinoma (ACC). ACT management is currently relying on the surgical approach; however, the identification of novel …
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Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… in increased aldosterone secretion from an adrenocortical carcinoma cell line, H295R, when transiently transfected with the mutants. I also showed that CaV1.3 can play a role in physiological aldosterone secretion, finding that CYP11B2 expression is reduced by 50% in the adrenals of CaV1.3 …
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Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
… of germline TP53 mutations in children with adrenocortical tumors, choroid plexus tumors and early childhood rhabdomyosarcomas and investigate whether these may be early manifestations of Li-Fraumeni syndrome (LFS). Germline TP53 mutations were found in few children with adrenocortical tumors …