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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Adrenocortical"”.
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Uncovering p53 Mutations and Abnormal Gene Expression in Pediatric Adrenocortical Cancer
<p>Pediatric adrenocortical cancer is extremely rare and often fatal (approximately 0.3-0.4 cases per million worldwide; 50% 5-year survival). The incidence of pediatric adrenocortical cancer in southern Brazil is 10-15 times higher than the worldwide incidence. Due to the rarity of adrenocortical …
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Regulation and Function of GATA Transcription Factors in Adrenocortical Tumors and Granulosa Cells
… expression of GATA-4 and GATA-6 is detected in adrenocortical tumors. The aim of this study was to elucidate the function of these factors in adrenocortical tumor growth. In embryonal development, the adrenocortical cells arise and differentiate from a common pool with gonadal steroidogenic …
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THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.
Adrenocortical carcinomas (ACC) are highly aggressive tumors with very limited treatment options. Alterations in cell cycle-related genes have been identified as key ACC drivers, and they are largely present in the most aggressive tumor subtypes. Compared to benign adenomas (ACA), the cytoskeletal …
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The cytology of adrenocortical regeneration in the rat and the effects of x-irradiation
… were obtained from three related studies of adrenocortical regeneration which may be characterized as follows: the cytology of (a) adrenocortical regeneration after immediate autotransplantation, (b) adrenocortical regeneration after in vitro x-irradiation of the adrenal gland and (c) the …
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Exploring the role of molecular imaging in the diagnosis and management of primary adrenocortical disease
… previously been shown to have high affinity for adrenocortical tissue (targeting the key enzymes CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase). This thesis examines the potential roles for molecular adrenal imaging with MTO PET in the management of (i) adrenal incidentalomas which …
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Co-Culture of Amphibian Adrenal Cells: A Model of Medullary Control of Corticosteroidogenesis
Chromaffin-adrenocortical cellular interactions have become recognized as an important component of adrenocortical regulation, however, the mechanisms by which chromaffin cells modulate adrenocortical function are not well understood. To study chromaffin-adrenocortical cellular interactions …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
Adrenocortical tumours (ACT) are a highly heterogeneous class of endocrine cancers, ranging from the common adrenocortical adenoma (ACA) to the rare and aggressive adrenocortical carcinoma (ACC). ACT management is currently relying on the surgical approach; however, the identification of novel …
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Investigating the maintenance of the mouse definitive adrenal cortex
… and the mechanisms by which differentiated adrenocortical cells are replenished in the adult mice. BrdU pulse-chase studies provided valuable information about cell division and cell fate under physiological or pathophysiological stimulations. The distribution of adrenocortical cells with …
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Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
… (ACTH) stimulated 3H-PAH uptake into bovine adrenocortical cells, which could be inhibited by probenecid. Cortisol, glutarate and PAH in the incubation medium also cis-inhibited 3H-PAH uptake, and preincubation with PAH trans-stimulated 3H-PAH uptake. Preliminary studies on human …
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Regulation of cortisol secretion in humans: relation to vasopressin action at the adrenals in macronodular and micronodular adrenocortical tumours; and well-being in Addison’s Disease.
… a convenience sample of patients presenting with adrenocortical hormone hypersecretion states or incidentally discovered adrenal tumours, and an attempt to simultaneously examine the negative predictive value of nocturnal salivary cortisol (NSC) sampling to detect the prevalence of mild CS in …
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Methods and Mechanisms of DNA Methylation in Development and Disease
… have applied the method to gonadectomy-induced adrenocortical neoplasms and to maturing motor neurons. The novel method, called Laser Capture Microdissected-Reduced Representation Bisulfite Sequencing (LCM-RRBS), accurately and reproducibly profiles genome-wide methylation of DNA extracted from …
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CARCINOMA CORTICAL DA ADRENAL NÃO FUNCIONAL COM INVASÃO DA VEIA CAVA CAUDAL EM CÃO
… examination and was confirmed the diagnosis of adrenocortical carcinoma. It is concluded that adrenocortical carcinoma is a rare neoplasm in dogs, however, it is believed that even when detected, they are not properly notified, which makes it necessary the adoption of diagnostic measures in the …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
… mRNA by post-transcriptional mechanisms in human adrenocortical carcinoma cell line (H295R cells). Protein kinase C (PKC) activator, phorbol-12-myristate-13-acetate (PMA), showed that the downregulation of hAT1R mRNA is mediated by the PKC pathway. Experiments performed in the presence of …
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A Study of Pathological Conditions in Wild Rodents (Rattus Norvegicus) with Respect to Seasonal Variations and Endocrine Imbalance
… Pitelka, 1957; Lidicker, 1966; Kalela, 1957); adrenocortical function (Bronson, 1967; Louch and Higginbotham, 1967; Dougherty, 1953; Christian and Davis, 1956; Christian, 1963a; Bronson and Eleftheriou, 1963; Andrews, 1968a); and mortality (Calhoun, 1949; Chitty, 1964; Krebs, 1964; Sadlier, …
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The plasma corticosteroids: their determination and normal variations
… the body. The need for accurate measurement of adrenocortical function has therefore been accentuated in recent years. The purpose of this study was to find out as direct a method as possible for determining the rate of secretion of this gland and to define with this method the norms and normal …
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Studies in cholestrol metabolism
… cholesterol are known. It is a precursor of the adrenocortical hormones (perhaps not an obligatory one ), and is probably important in the biosynthesis of sex hormones too. Present in the skin is 7-dehydrocholesterol, converted to vitamins D by ultraviolet light. Cholesteryl esters are found in …
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