Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Adrenoceptors"”.
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Central Alpha-Adrenoceptors and Behaviour
A range of agonists and antagonists were found to show selectivity peripherally for α1 and α2 receptors in vitro. Further studies showed that drugs showing elective effects at a2 receptors were able to modify the release of noradrenaline from central neurones. Behavioural studies were undertaken …
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The role of the catecholaminergic projections to the forebrain in the modulation of autonomic responses to stress
… amygdala (CeA). Injections of an antagonist of Ý-adrenoceptors into each of these regions reduced the magnitude of the increase in HR induced by tail pinch. Injections of an agonist of Ý-adrenoceptors in the MFC, AIC and NAC increased basal HR but did not affect the pinch response. Injections of …
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Exploring the effect of alpha2 receptor on brain 5-HT via a mechanism-based pharmacodynamic model
… in depression. It is believed that α 1 and α 2 adrenoceptors mediate the 5-HT level in the brain. The mechanism is complex and not well explored. Especially in different combination treatments, the receptor systems may show varied modulation capability. Additionally, some research has suggested …
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Reciprocal Relationships Between the Neuroendocrine System and Lymphoid Cells
… cortisol increases the number of (beta)-adrenoceptors on non-stimulated splenocytes. Cortisol prevents the concanavalin A-induced increase in glucocorticoid receptors while the (beta)-agonist, isoproterenol, prevents the mitogen-induced increase in (beta)-adrenoceptors. Both cortisol and …
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Dual Mechanism Analgesia-Enhancing Agents
… have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. MD-354, …
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Intrarenal Adrenergic Mechanisms Controlling Renin Release
… to investigate the role of alpha- and beta-adrenoceptors in the control of renin release. In addition, the function of calcium in the adrenergic control of renin release was examined. All studies were carried out in the isolated, nonfiltering, constant-pressure perfused rabbit kidney.
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Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
… specific activation of hypothalamic $\alpha\sb1$ adrenoceptors sharply stimulates the release of LHRH. This effect occurred in hypothalami from proestrus and ovariectomized rats with or without estrogen.
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The role of eicoapentaenoic acid in cancer cahexia
… transduction pathway involving, possibly, β3-adrenoceptors. Oral administration of the n-3 polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA) attenuated the progression of cachexia, but not the production of LMF, in MAC16 tumour-bearing mice, and was significantly incorporated into …
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Interventions against obesity through increased lipolysis in adipose tissue
… was mediated via a pathway involving the f3 adrenoceptors and components of the lipolytic signalling pathway, including protein kinase A and p38 MAP kinase. In addition, M2 and mazindol were capable of increasing glucose uptake into insulin sensitive tissues. M2 and mazindol can act directly …
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Impact of Glycemic Therapy on Myocardial Sympathetic Neuronal Integrity and Left Ventricular Function in Insulin Resistant Diabetic Rats: Serial Evaluation by 11C-meta-Hydroxyephedrine Positron Emission Tomography
… evaluated serially and expression of NET and β-adrenoceptors were tested at the terminal endpoints. Diabetic rats exhibited a 52-57% reduction of [11C]HED standardized uptake value (SUV) at 8 weeks after STZ, with a parallel 2.5-fold elevation of plasma NE and a 17-20% reduction in cardiac NET …
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In vivo and in vitro aspects of imidazoline-2(1/2)sites within the central nervous system
… associated with the selective activation of α1-adrenoceptors and possibly 5-HT receptors. 2-BFI trained rats recognise reversible MAO-A but not MAO-B inhibitors. However, data within this thesis indicates the autoradiographical distribution of I2 sites bears a closer resemblance to that of MAO-B …
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The electrophysiology of the atrioventricular node in normal and failing rabbit hearts
… with evidence of downregulation of beta ()-adrenoceptors in the left ventricular myocardium. I therefore explored the possibility of β-adrenoceptor downregulation in the AV node as a mechanism underlying the abnormal AH interval prolongation in LVD. There was no evidence of β-adrenoceptor …
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Optimising therapeutic strategies for chronic rhinosinusitis
The aim of this thesis is to evaluate and optimise current pharmacotherapeutic options in rhinosinusitis. There is often a marked variation in treatment response in those afflicted with chronic rhinosinusitis, both within and between patients, attributable in part to different disease …
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How does pulmonary exposure to particulate matter predispose the heart to increased injury after myocardial infarction?
… to involve secondary activation of systemic β1 adrenoceptors.