Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 263 for “"Adrenergic"”.
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Adrenergic-cholinergic interactions in the heart
In the mammalian atrial myocardium the muscarinic receptor agonist carbacholcan inhibit the positive inotropic responses to isoproterenol, a f3-adrenoceptor agonist, forskolin, a direct activator of adenylate cyclase, IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor …
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Intrarenal Adrenergic Mechanisms Controlling Renin Release
… In addition, the function of calcium in the adrenergic control of renin release was examined. All studies were carried out in the isolated, nonfiltering, constant-pressure perfused rabbit kidney.
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… (E) and norepinephrine (NE). The α- and β-adrenergic receptors (ARs) are encoded by 6 α- and 3 β-AR genes and these ARs mediate interactions between the stress hormones E and NE and immune cells. However, AR gene expression and function have been studied to a limited extent in bovine immune …
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Sustained Adrenergic Signaling Promotes Cervical Cancer Progression
<p>Background: Chronic stress and sustained adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of …
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Adrenergic control of proteolysis in brown adipocytes
… or proteolysis within mitochondria, under adrenergic influence. Mouse pre-adipocytes in culture differentiated to brown adipocytes. Increased expression of UCP1 was induced by norepinephrine (NE). NE was then removed and the pattern of change in thermogenic capacity evaluated. The number of …
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… downregulation, and recycling of β Adrenergic Receptors (βAR). Several AKAPs have been associated with cardiac function. AKAPs cardiac expression levels and intracellular distribution are altered under pathological conditions; however, AKAP12 cardiac roles are unclear. In this study, …
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Adrenergic regulation of splenic functions in neonatal pigs
The purpose of this study was to assess adrenergic control of splenic hemodynamic function and oxygen metabolism in neonatal pigs (NP). Seventeen piglets, 28-45 days of age, were anesthetized with pentobarbitol (30 mg/kg, i.p.) and prepared for measurement of splenic venous outflow. Simultaneous …
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Characterization of α₂-adrenergic receptor localization and functional responses
The three α₂-adrenergic receptors (α₂-ARs) were studied in both recombinant and endogenous systems. It was my general hypothesis that the three α₂-adrenergic receptor (AR) subtypes exhibit differential tissue and subcellular localization and couple to physiological pathways to directly elicit …
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Investigating the molecular signatures of β1-adrenergic receptor activation
… signatures of receptor activation, using the β1-adrenergic receptor (β1AR) as a prototypical class A G-protein coupled receptor (GPCR). I have used a minimally thermostabilised turkey β1AR and expressed it functionally in insect cells using a baculovirus system. The work described here …
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Effects of Pasteurella haemolytica on Pulmonary Vascular Adrenergic Mechanisms
… by disruption of the pulmonary vascular adrenergic system. However, only a limited amount of research has addressed the adrenergic system and its relationship to the etiology and pathophysiology of this disease. In an attempt to further investigate the contributions of the vascular …
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Sex differences in the cardiac beta-adrenergic receptor contractile response
… is not present following menopause. &beta-adrenergic receptors are pharmaceutical targets in the treatment of cardiovascular disease, and sex differences in &beta-adrenergic responsiveness have been demonstrated. However, limited studies have addressed the mechanism(s) underlying these …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… it has been found that activation of β-adrenergic signaling pathway leads to aggressive variants of prostate cancer. β-adrenergic signaling involves the activation of β-adrenergic receptors (ADRBs), eventually leading to increased activation of cAMP response element-binding protein …
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Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… of heart disease and diabetes are the adrenergic receptors (ARs) and insulin receptors (IR), respectively. Classically considered to elicit separate, and even opposing, cellular processes, increasing evidence suggests that ARs are capable of signaling cross-talk with other G-protein …
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Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
… is primarily under the control of the $\alpha$ adrenergic system. The $\alpha$ adrenergic receptor subtype mediating LHRH release has not been established however. Also, most investigators have used changes in plasma luteinizing hormone to infer changes in hypothalamic LHRH release, rather than …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
… signaling processes. The thermostable turkey β1-adrenergic receptor (tβ1AR) is a prototypical class A GPCR widely used in structural studies and is activated by catecholamine ligands, adrenaline, and noradrenaline. Although many crystal structures of tβ1AR are published, there is little known …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… sympathetic nerve endings. The nerve termini are adrenergic and secrete norepinephrine upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential …
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Role Of The α1A-Adrenergic Receptor In Synaptic Plasticity, Cognition & Neurogenesis
… involved in learning and memory. NE activates adrenergic receptors (ARs) and stimulating the α1A-AR subtype has been known to increase adult neurogenesis (ANG). We hypothesized that α1A-AR-induced ANG would enhance learning and memory. Constitutively active mutant (CAM) α1A-AR, α1A-AR knock-out …
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Interaction between Adrenergic and Nitric Oxide-releasing Nerves in Cerebral Arteries
… intrinsic and extrinsic control factors of which adrenergic and nitric oxide-releasing nerves are components. My research examined the interaction between these two nerve-types with emphasis on the mechanisms involved as well as on changes in their functions as the animal adapts to stress such as …
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