Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Adp Receptors"”.
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ADP regulation of insulin secretion and beta-cell apoptosis
… β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 …
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The Regulation of Phosphorylation Events in Platelets
… released from dense granules such as ADP, and serotonin, play an essential role in potentiating the platelet response through activation of other surface receptor mediated pathways. Importantly, downstream of all these separate pathways, kinases become activated and play a crucial role …
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CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS
… selectively binding to adenylate cyclase-coupled ADP receptors. It is indicated for the reduction of atherosclerotic events. Its structure contains a stereocenter: since only the S(+) isomer is biologically active, the compound must be prepared in the enantiomerically pure form. Although it is …
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Pharmakologie der ADP-Rezeptoren auf humanen Thrombozyten
… lange Zeit auf die Beschreibung als ADP-Rezeptorantagonist beschränkt. Im Zuge neuerer Erkenntnisse zum Mechanismus der Auslösung einer Aggregation, insbesondere der ADP-vermittelten Aggregation, sollte im Rahmen dieser Dissertation der Wirkmechanismus der Thienopyridine genauer …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… Clopidogrel on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules and is released upon platelet activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class …