Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Adoptive immunotherapy"”.
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Cellular and Molecular Aspects Of Naïve T cell Priming for Adoptive Immunotherapy
Over the past decade immunotherapy has emerged as a powerful tool in the treatment of advanced cancer and recurrent viral diseases. In particular, clinical success with Immune Checkpoint Blockade has led to the rapid approval of immunomodulating drugs for the treatment of metastatic cancers. …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
… and antitumor activity</strong></p> <p>Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by the expression of a chimeric antigen receptor (CAR). Infusion of CAR-modified T cells for the treatment B-cell malignancies …
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
… activity, hence are an attractive choice for immunotherapy applications. Owing to small numbers of NK cells in peripheral blood (1-32%, with a 6% median), ex vivo expansion of NK cells is critical for NK cell adoptive immunotherapy, various expansion platforms have been explored over the …
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A novel model system for the study of anti-tumour T-cell memory
An adoptive immunotherapy (ADI) protocol was developed where the fate and requirements of longterm persisting memory T-cells can be monitored. Anti-tumour immune peritoneal exudate cells (iPEC) were produced by injecting a subtumorigenic dose of the highly metastatic, ß-gal<sup>+</sup> T-Iymphoma …
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High-Throughput Single-Cell Functional and Molecular Profiling of Immune Cells in Cancer Immunotherapy
Immunotherapy has revolutionized the treatment of cancer and newer approaches including the adoptive transfer of genetically modified T cells reprogrammed to target tumor antigens have shown remarkable responses. Despite their promise, the efficacy of adoptive immunotherapy remains unpredictable …
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Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells
… enhance T cell activity. For successful cancer adoptive immunotherapy, a coordinated approach of BsAb arming of retrovirus-gene-modified T cells can be utilized for delivery of beneficial, tumoricidal molecules to the tumor site.
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Selezione e processazione di cellule Natural Killer da donatore aploidentico "KIR-ligand" incompatibile per l'immunoterapia adottiva di pazienti con Leucemia Acuta Mieloblastica ad alto rischio
… risk AML patients entered a phase I-II study of adoptive NK-cell based immunotherapy and were screened for the availability of one haploidentical KIR ligand mismatched donor. Thirteen of them resulted as having one suitable donor. NK cells were enriched from steady-state leukaphereses by using a …
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In vitro generation and programming of human CD8+ memory T cells
… protocol with potential implications for adoptive immunotherapy. With this priming regime, a short duration of IL-2 supplementation was found to augment the expansion of naïve CD8+ T cells without significantly altering cellular attributes. Transcription factor expression was also examined …
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Stimulation of donor t-cells with leukemic blast-loaded dendritic cells for the generation of leukemia-specific immunity in the context of allogeneic stem cell transplantation
… by the infusion of donor lymphocytes (DLI). Adoptive immunotherapy involving DLI, the current approach in relapsed allogeneic transplant patients, leads in this situation to a complete remission rate of 42%. Unfortunately, DLI is often complicated by graft versus host disease (GVHD), a …
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THE DESIGN OF A NOVEL ANTI-TUMOUR DRUG DELIVERY SYSTEM USING IMMUNE-DERIVED CELLS.
… specifically to tumours and metastases and the adoptive immunotherapy of monocytes and/or macrophages. It involves encapsulation of chemotherapeutic drug within a liposomal matrix which affords protection from the host-immune response by uptake of the drug-liposome, combination into macrophages. …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
A patient’s own T cells can be genetically modified and amplified in the laboratory to target antigens expressed on tumour cells through the introduction of chimeric antigen receptor (CAR) genes. Despite considerable advances in the treatment of B cell leukaemia using chimeric antigen receptor T …