Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Adoptive T-cell Therapy"”.
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
Immunotherapy in general and adoptive cell transfer in particular have recently been in the spotlight of cancer research. Recent FDA approval of the first immunotherapeutic drugs and promising results in clinical trials suggest that this therapeutic modality holds great promise in fighting cancers. …
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Evaluation of Adoptive T Cell Therapy and Oncolytic Virotherapy for Treatment of Brain Tumors
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2013-01-22T11:00:26Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 3 Thomas_Diana.pdf.txt: 257425 bytes, checksum: …
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Activating The 4-1Bb Pathway For The Expansion of Tumor-Infiltrating Lymphocytes For Adoptive T-Cell Therapy For Metastatic Melanoma Patients
… the tumor-infiltrating lymphocytes (TIL) used in Adoptive T-cell therapy by understanding the role of 4-1BB/CD137 co-stimulation during the expansion of the tumor-infiltrating lymphocytes (TIL). Adoptive T-cell therapy using TIL is a promising therapy for late stage melanoma patients, resulting in …
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Characterization and Optimization of Antigen-Specific T Cell Responses During Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes
… of metastatic melanoma with tumor reactive T cells (adoptive T cell therapy, ACT) is a promising approach associated with a high clinical response rate. However, further optimization of this treatment modality is required to increase the clinical response after this therapy. ACT in melanoma …
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Immunotherapy for murine glioma
Oncolytic viral immunotherapy is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We …
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The Characterization of T-Cell Manufacturing For Adoptive T-Cell Therapies
<p>Adoptive T-cell therapy using genetically modified T cells has emerged as a potential therapeutic option for several malignancies. Central to the production of the cellular therapy is the manufacturing using a stimulation, genetic engineering, and expansion methodology. Within this framework, …
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Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines
… release levels by antigen specific effector T cells when antigen is crosspresented by dendritic cells (DC) which absorbed mBD2 vaccine (mBD2 fused antigen protein) over antigen alone. We move unto an in vivo model and note significant increases in the expansion of antigen specific class I T …
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Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma
… have shown promising results, including therapy with adoptive cell transfer (ACT) of T lymphocytes. T cell immunotherapy is highly attractive because T cells have the ability to selectively recognize and destroy malignant neoplastic cells. Although a promising approach, one of the …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… have seen important advances in the area of T cell-based therapy for human malignancies. Epstein Barr virus-associated tumours like Hodgkin’s Lymphoma provide important models in this field. If a T cell-based therapy is to be effective however, T cells must be capable of trafficking to the …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… Professor: Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier against effective T cell mediated cytotoxicity is immunosuppression in the tumor micro-environment. It has been described …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
Regulatory T cells are one of the integral components of the adaptive immune system that contribute to the regulation of anti-tumor T cell responses. However, studies have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of …
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… metastatic melanoma patients. Clinical trials of adoptive T-cell therapy (ACT) using autologous <em>ex vivo </em>expanded TIL have demonstrated the great potential of this immunotherapy with an overall clinical response rate 40-50% for stage IV metastatic melanoma patients. We have investigated a …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… regulated pathway involved in embryogenesis, cell polarity, and migration. Dysregulation of Wnt signalling is associated with abnormal cellular growth contributing to cancer formation. Especially in colorectal cancer (CRC) mutations in the Wnt pathway that enhance signalling are driving forces …
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Developing Novel Approaches to Improve Response to T Cell Based Cancer Immunotherapy
<p>Recently, T cell based immunotherapies have moved to the forefront of cancer immunotherapy with the success of Adoptive T cell therapy (ACT) and Immune checkpoint blockade.ACT, where patients are treated with tumour infiltrating T cells (TILs), conferred a clinical response rate of ~50%. …
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Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients
… unmet need for a treatment that can target chemotherapy-resistant blasts with low off-tumor toxicity. Approaches to prevent GvHD while maintaining or enhancing graft-versus-leukemia (GvL) are the ‘Holy Grail’ for allo-BMT patients. CD3+ CD4- CD8- double negative T cell (DNT) is an unconventional …
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Engineering human single-chain T cell receptors
The alpha-beta T cell receptor (TCR) is responsible for mediating T cell recognition of self and non-self tissues, through recognition between a complex of a peptide and a product of the major histocompatibility complex (pepMHC) on target cells. In the immune response to cancerous tissue, the …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared CD8<sup>+</sup> TIL against the T cells from matched melanoma patients’ peripheral blood. We discovered a novel subset of CD8<sup>+</sup> TIL co-expressing early-differentiation markers, CD27, CD28, and …