Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Adipose-derived Stem Cells"”.
-
Functional Tissue Engineering of Cartilage Using Adipose-derived Stem Cells
… a functional tissue engineering approach using adipose-derived stem cells (ASCs). ASCs are an abundant progenitor cell source easily obtained through a minimally invasive liposuction procedure. When appropriately stimulated, ASCs have demonstrated significant potential for chondrogenic …
-
Characterization and application of adipose derived stem cells following burn injury
… prolonged inflammatory response in subcutaneous adipose tissue that modulates signaling in adipose-derived stem cells (ASCs), which hold potential for healing burn wounds or generating skin substitutes. Using a 60% rat scald burn model, we investigated the cellular source of inflammation within …
-
Development of Delivery Strategy for Adipose-Derived Stem Cells in the Treatment of Myocardial Infarction
Cell-based therapies involving adipose-derived stem cells (ASCs) have shown promise in stimulating cardiovascular regeneration, including in the treatment of myocardial infarction (MI) and ischemic heart disease. However, previous studies involving the delivery of ASCs following MI have indicated …
-
Modulation of human adipose-derived stem cells and dermal fibroblasts in co-cultures by activation of the IL-6 trans-signalling pathway via the soluble IL-6Rα receptor
… between human dermal fibroblasts (DF), human adipose-derived stem cells (ADSC), IL-6 and activation of the IL-6 trans-signalling pathway under four different cell culture conditions. The two cell types were co-cultured to assess cell migration when pre-treated with the soluble human IL-6Rα …
-
Towards an autologous tissue engineering construct for craniofacial bone repair
… such as scaffolds, growth factors and adult stem cells, can be derived from patient blood and adipose tissue and are potential autologous therapeutic options. This dissertation investigates a prospective procedure to improve craniofacial bone healing using fibrin scaffolds and platelet rich …
-
Characterization of human adipose tissue-derived adult multipotent precursor cells
… the existence of a putative subpopulations of stem cells in the adipose tissue stroma. These adipose derived stem cells (ADSCs) under certain conditions express characteristics of various mesenchymal lineages. This thesis showed that 1,25a??dihydroxyvitamin D3 worked synergistically with …
-
Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process
Mesenchymal stem cells (MSC) are an important component of many tissue engineering and regenerative medicine (TE/RM) strategies. Their multipotential characteristics make them extremely useful as a source of cells for TE/RM applications. Adipose-derived stem cells (ADSC) represent one type of MSC …
-
Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases
… liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) …
-
The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
… investigate the therapeutic efficacy of adult, adipose derived stem cells (ADSC). The paralyzed mice that received ADSC transplantation demonstrated significantly improved motor function, likely due to stromal support provided by ADSCs. The ultrastructure of the nerve was not significantly …
-
Impact of obesity on stromal vascular fraction in adipose tissue as it relates to ovarian cancer
… in addition to the adipocytes, abdominal white adipose tissue contains the stromal vascular fraction (SVF) which includes stem and progenitor cell populations, immune cells, and fibroblasts. Since the SVF can also be recruited by the cancer cells, we investigated how obesity affects the survival …
-
3D printing of hyaluronic acid scaffolds for tissue engineering applications
… modulus of articular cartilage. Porcine adipose derived stem cells (ASCs) are cultured on HAGM scaffolds with the aim of inducing chondrogenic differentiation. Cartilage formation on 3D printed scaffolds is better distributed within the scaffolds relative to 2D controls, and new tissue is …
-
Label free imaging of cell attachment by photonic crystal enhanced microscopy
… of a photonic crystal for imaging live cells. The imaging instrument utilizes a monochromatic angle-tunable illumination to achieve resonant conditions within the crystal sensor in order to image cells by their higher reference index than the surrounding media. Due to evanescent decay, …
-
Adipose Tissue And Its Role In Modulating The Mammary Tumor Microenvironment
Targeting cancer cells has been the primary focus of most cancer therapies, and only recently has the interaction of cancer cells with host stroma been recognized as a driving force for cancer evolution. In the presence of tumor-derived physicochemical cues, the host stroma fails to fulfill its …
-
Establishing a Model of Organ regeneration in the Adult Mammal: Age Dependence and the Utility of Non-Invasive Imaging
… was not reversed by local administration of adipose derived stem cells at the time of STC. These studies establish an age-dependent model of mammalian organ regeneration that may be utilized to identify molecular regulators of (un)successful regeneration. While targetable pathways specific to …
-
PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
… enhancing the therapeutic potential of stem cells injected into ischemic microenvironments by novel preconditioning (PC) techniques is critical for improving cellular therapy. Recent studies have shown that inhibition of phosphodiesterase-5 (PDE-5) is a powerful strategy to precondition …
-
Antimicrobial PLA and Calcium Phosphate Coatings and Thin Film Composites for Implants Applications
… requires the use of large doses of antibiotics systemically. Large doses can lead to a number of side effects including antibiotic resistance and adverse effects on the other organs. These infections delay healing, worsen functional outcome and incur significant socioeconomic costs. Bone implant …
-
Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
… address its underlying pathology; however, stem cell-based approaches aimed at repairing diseased tissues may overcome this limitation. Therapeutic effects of stem cells may be due in part to paracrine actions, including some mediated by exosomes – extracellular vesicles secreted by cells …
-
Adipose stromal cells enhance keratinocyte survival and migration in vitro, and graft revascularization in mouse wound healing model
… factor application. We propose the delivery of adipose derived stem cells (ASC) in combination with endothelial progenitor cells (EC) via Integra Dermal Regenerative Template (DRT) to promote faster graft vascularization and thus faster healing of wounds. Integra DRT is an acellular skin …
-
Cardiac Organogenesis: 3D Bioscaffolds, Bioenergetics and Regeneration
… could be successfully seeded using endothelial cells for acellular vasculature and stem cells for other acellular tissues, both as a 2D matrix and within a constantly perfused 3D Langendorff setup bioreactor. In order to best understand cell-cell and cell-matrix interactions, cellular …
-
Development of Bioelectronic Technologies for the Investigation of Extracellular Vesicle Function and Anti-Cancer Drug Discovery
… the transfer of active biomolecules between cells, both in the vicinity of the source cell and at distant sites, to elicit a variety of phenotypic responses. Tumour-derived (T)EVs facilitate the transfer of information between tumour and non-malignant cells to initiate and drive metastasis …
Page 1 of 2