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Showing 1 to 13 of 13 for “"Adipose tissue metabolism"”.
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Lipogenesis in the Ruminant and the Influence of Diethylstilbestrol on Adipose Tissue Metabolism
Made available in DSpace on 2014-12-10T22:30:23Z (GMT). No. of bitstreams: 1 7212225.pdf: 3450549 bytes, checksum: 4ce2a4afddf3572a2782e7d050d46f60 (MD5) Previous issue date: 1971
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
Numerous studies have investigated how bulk lipid metabolism is influenced in obesity and in particular how the composition of triglycerides found in the cytosol change with increased adipocyte expansion. However, in part reflecting the analytical challenge the composition of cell membranes, and in …
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Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, <i>Ictidomys tridecemlineatus</i>.
Brown adipose tissue (BAT) is the major thermogenic tissue in small eutherian mammals. In hibernators, seasonal modifications of BAT are well documented but little is known about its functional regulation during hibernation. BAT metabolism is activated by sympathetic stimulation, so I hypothesized …
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Depot differences in adipose tissue metabolism and function in obese black South African women and changes in response to an exercise training intervention
… associated with depot-specific alterations in adipose tissue function. This thesis aimed to evaluate the differences in fatty acid (FA) composition and gene expression between abdominal (aSAT) and gluteal subcutaneous adipose tissue (gSAT), and the changes in response to exercise training in …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… Mitochondria, central to ATP production, lipid metabolism, and thermogenesis, play a crucial role in modulating white adipose tissue metabolism. This thesis explores an innovative strategy for addressing mitochondrial dysfunction in obesity which is a critical aspect of this multifactorial …
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… vital role in regulating energy homeostasis and adipose tissue metabolism. It has been demonstrated that ERα is abundantly expressed in the ventrolateral region of the ventromedial hypothalamus (vlVMH), a sex-dimorphic structure that directly modulates brown adipose tissue (BAT) thermogenesis. We …
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Altered regulation of adipogenesis with respect to disease processes
Dysregulation of adipose tissue metabolism is associated with multiple metabolic disorders. One such disease, known as Dunnigan-type familial partial lipodystrophy (FPLD2) is characterised by defective fat metabolism and storage. FPLD2 is caused by a specific subset of mutations in the LMNA gene. …
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Molecular and cellular mechanisms of energy homeostasis in birds
Hypothalamus and adipose tissue are essential central and peripheral sites regulating energy homeostasis. Disruption of energy homeostasis can lead to diseases like anorexia and obesity in humans and reduced productivity in animals. Therefore, integrating knowledge in hypothalamic appetite …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… nutrition. 2) effects of genetic merit on lipid metabolism in adipose tissue. For the objective of first experiment, we examined mRNA expression via qPCR of endocannabinoid receptors (CNR1, CNR2), enzymes that synthesize FAE (HRASLS5, NAPEPLD), enzymes that degrade FAE (FAAH, NAAA, MGLL), and the …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… with a focus on the mechanisms involving lipid metabolism, oxidative stress and inflammation, intestinal permeability, and telomere integrity. The research was structured into three main chapters, combining both in vitro and in vivo approaches. In Chapter 1, the mechanisms of action of selected …
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
Estrogen plays an important role in adipose tissue (AT) metabolism. Post-menopausal estrogen loss leads to increased abdominal fat and worsened metabolic outcomes. Exercise, known to enhance energy expenditure and promote AT browning, may offer therapeutic potential to mitigate these adverse …
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The Functional Cellular Identity and Interconversion of Human White, Beige, and Brown Adipocytes
… invasive. With the recent discovery of brown adipose tissue activity in human adults, adipocyte thermogenesis has received significant interest due to its therapeutic potential for reversing obesity, or in assisting orthogonal treatment approaches. However, while metabolic changes in the form …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… analyzed the role of this enzyme in obesity and metabolism. Studies in the past 5-10 years utilizing various knock- out or over-expression mouse models have analyzed the role of different secretory phospholipase A2s (sPLA2) in metabolic diseases. From these studies, it is known that at least …