Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 591 for “"Adipose"”.
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ADIPOSE TISSUE GROWTH AND MAINTENANCE
… new importance. Characterized by an increase in adipose tissue to the point where it is associated with adverse health effects, the prevalence of obesity has nearly tripled over the past fifty years. Though for many years adipose tissue was considered to be merely a storage depot for fatty acids, …
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Transcriptional regulation of adipose insulin resistance
… epidemic. The obesity association also makes adipose tissue the target of interest for ongoing research. Previous work on adipose insulin resistance has largely been focused on deciphering the signaling defects and abnormal adipokine secretion profiles. There is increasing awareness that …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, we …
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White Adipose Tissue Remodeling by Intermittent Fasting
… regulator of energy balance, understanding white adipose tissue (WAT) homeostasis and its response to dietary challenges is crucial to reveal the mechanisms of IF-mediated metabolic benefits. Particularly, recent studies highlighted the role of dysfunctional adipocyte progenitors (APs) in …
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Genetic Analysis of Adipose Lineage and Development
Adipose tissues protect t against traumatic and thermal insults, and regulate lifespan, reproduction and metabolism. The importance of forming the appropriate number of adipocytes is highlighted by the significant metabolic disturbances that accompany too few (lipodystrophy) or too many (obesity) …
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Enhancement of Hiv Persistence By Adipose Tissue
… and gastrointestinal lymphoid tissues, but adipose tissues could potentially harbor HIV as well. Adipose tissues are ubiquitous connective tissues and major sites of infiltration and immune activity by T cells and macrophages. As adipose tissue regulates CD4 T cell migration and functions, …
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Anti-Obesity Effects of Adipose-Targeting Resveratrol Nanocarriers
… excess energy is stored in the form of fat in adipose tissue, and weight gain occurs. Since induced brown-like/beige adipocytes have the same thermogenesis and metabolic sink functions as classical brown adipocytes, browning subcutaneous white adipose tissue (WAT) might be a practical and …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… and chronic activation of immune cells into adipose tissue as well as many other tissues such as liver, skeletal muscle and pancreas. Therefore, targeting immune cells to reduce inflammation is an important weapon to treat obesity related syndrome. Interestingly, deficiency of fatty acid …
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Characterization of porcine adipose tissue-derived stem cells
… not been identified in stem cells from porcine adipose tissue, an easily attainable tissue resource. The phenotypic profile of cell surface proteins and chromosomal stability of porcine adipose tissue-derived stem cells (pASCs) through in vitro culture have not been described. Also, research has …
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Obesity, visceral adipose tissue, and cognition in childhood
… In addition to weight status, central adipose tissue is particularly dangerous, with visceral adipose tissue being linked to higher risks of metabolic diseases and cardiovascular complications. However, the relationship between central adiposity and brain health and cognition during …
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The role of the mitofusins in adipose tissue
… It is not known why this mutation affects adipose tissue when other mutations in MFN2 cause a peripheral neuropathy. More generally, it is not clear how mitochondrial dynamics affect adipogenesis and adipokine secretion. Therefore, we aimed to broaden and deepen our understanding of the …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
Background: Excess white adipose tissue (WAT) in humans is considered as a harmful health index. However, increased brown adipose tissue (BAT) and brown-like adipose tissue activity are associated with increased resting energy expenditure (REE) that may help to control body weight. Exercise may …
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THE ASSOCIATION OF VISCERAL ADIPOSE TISSUE WITH PULSE PRESSURE
Background: Obesity and aortic stiffness (AS) contribute to cardiovascular disease (CVD). Central obesity as measured by VAT is thought to be a more specific measure of deleterious adiposity independent of body mass index (BMI). However, the nature of the relationship between VAT and AS in …
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The Aging-Induced Decline in Beige Adipose Tissue Development
… and obesity are associated with dysfunctional adipose tissue leading to the pathogenesis of numerous comorbidities including heart disease, type 2 diabetes, and numerous cancers. Unlike energy-storing white adipose tissue, beige adipose tissue burns energy in the form of heat and thus has …
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Hormone-Sensitive Lipase - New roles in adipose tissue biology
… the HSL gene in mice, with a focus on the white adipose tissue (WAT). The initial study demonstrated a mild insulin resistance in multiple tissues of the HSL null mice, which was almost fully compensated for by increased insulin secretion by the pancreatic beta-cells. The HSL null mice were …
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Interventions against obesity through increased lipolysis in adipose tissue
… intervention against obesity in which adipose tissue lipolysis will be combined with increased energy expenditure: the approach is also designed to consider agents that will benefit glycaemic control in coexistent obesity and diabetes by improving insulin sensitivity. Rodent and human …
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