Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"Adiponectin"”.
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Dietary, Genetic and Metabolic Determinants of Serum Adiponectin
The role of adiponectin, a cytokine produced in adipose tissue and its relationship to risk factors for the metabolic syndrome, and dietary influences on its production are reviewed. The thesis examines the hypothesis that the amount and type of fatty acids in the diet affect serum adiponectin …
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Measurement and validation of the nature of salivary adiponectin
Adiponectin (Ad) is an adipocyte-derived hormone that plays an essential role in regulating insulin sensitivity, inflammation and atherogenesis. Levels of some hormones in saliva change in a fashion similar to that in plasma in response to a disease or physiological change. Since saliva is an easy …
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
Adiponectin is an adipocyte-derived pro-inflammatory adipokine that regulates metabolic homeostasis, although it has been reported to modulate platelet function and thrombosis. In this study the effects of globular adiponectin (gAd), a novel platelet agonist that stimulates platelet aggregation was …
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Detailed Characterization of Structure-Activity Relationships in the Human Adiponectin Molecule
Adiponectin is an abundant circulating adipose tissue-derived hormone, or adipokine, that elicits distinct biological functions through its different oligomeric forms. Posttranslational modifications within its non-globular region have been demonstrated to be crucial for its formation of multimers …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… factor is altered adipokines profiles. Adiponectin is the most abundant adipokine in the circulation and a low serum adiponectin level is implicated in multiple diseases. Adiponectin acts on various tissues by improving energy metabolism and conferring protective effects. Majority of …
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The role of adiponectin and the adipocyte in energy metabolism and inflammation
… conducted to characterize the autocrine role of adiponectin in modulating fatty acid metabolism and inflammation in the pig. In the first study, we cloned and sequenced the porcine adiponectin open reading frame and evaluated the regulation of adiponectin, in vitro and in vivo. The porcine …
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Influence of Gender and Aerobic Training Background on Exercise-Induced Increase in Adiponectin
Adipose tissue secretes the adipokine, adiponectin (ADPN), which is insulinsensitizing, anti-inflammatory, and anti-atherogenic. Exercise training improves insulin sensitivity and lowers the risk of cardiovascular complications. As some of the metabolic effects of exercise training and ADPN …
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Investigation of High Molecular weight adiponectin in HIV -Infected patients on antiretroviral therapy
… the role of multimeric (high molecular weight) adiponectin in the development of metabolic disease resulting from anti-retroviral therapy. Specifically, the aim is to quantify the circulating levels of both total and high molecular weight (HMW) adiponectin and to establish whether a link exists …
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Adiponectin and Toll-Like Receptor 4: Important Adipocyte Modulators of Systemic Glucose and Lipid Metabolism
… hypertrophic adipose tissue are decreased adiponectin secretion and increased adipose tissue inflammation. Released almost exclusively from adipocytes, adiponectin exerts potent insulin sensitizing effects on peripheral tissues. Using a series of inducible mouse models, we identified an …
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Genetische und metabolische Regulation von Adiponectin : Resultate von in vitro und humanen in vivo Studien
… Fettstoffwechselstörungen sind mit erniedrigten Adiponectinspiegeln assoziiert. Eine Modulation des Adiponectins kann durch genetische und metabolische Gegebenheiten erfolgen. Das Ziel dieser Arbeit war die Analyse von Faktoren, welche die Adiponectinspiegel beeinflussen können, sowie eine …
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… of GDM. In addition, low levels of serum adiponectin are associated with increased risk for GDM. Adiponectin is an adipose tissue derived cytokine that improves systemic insulin sensitivity. Since adiponectin has a role in hepatic lipid metabolism, we hypothesize that adiponectin …
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The effects of chronic and acute exercise modalities on substrate utilization and plasma adiponectin concentration
… of plasma concentration of the hormone adiponectin. However, it has been suggested that increasing fatty acid oxidation at rest, via exercise or otherwise, may augment plasma adiponectin. The current literature addressing changes substrate utilization and possible direct effects on …
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GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY
… of a candidate gene, ADIPOQ, encoding the adiponectin protein. Adiponectin is an adipocytokine that has been implicated in a wide variety of biomedical pathways, including glucose homeostasis and energy metabolism.
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The role of adipokines (leptin and adiponectin) and lipids in the interaction between obesity and prostate cancer
… an overview of how the adipokines (leptin and adiponectin) and lipid profiles contribute to the interaction between obesity and prostate cancer, with each chapter using a different study design and research question in order to get a more complete picture of how obesity is linked to prostate …
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Assessment od Adiponectin and Endothelial Nitric Oxide Synthase levels in Black Zambian patients with Hypertension at the University Teaching Hospital, Lusaka
… in the pathophysiology of hypertension. Low adiponectin levels have been associated with hypertension and this might be due to its effects on endothelial nitric oxide synthase levels. Aims - In this study we aimed to assess plasma adiponectin and endothelial nitric oxide synthase in patients …
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The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases.
… not fully understood. The effect of leptin and adiponectin, which are two adipokines with opposing effects, has been explored in this study. In the present study, therefore, the concentrations of leptin and adiponectin with significant effect on beta cell and endothelial cell function and the …
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Les effets de traitements aux acides gras polyinsatures omega-3 a longue chaine sur la secretion d'adiponectine de preadipocytes humains differencies
… polyunsaturated fatty acids (LCn-3PUFA) on adiponectin levels has been observed in several animal and human studies after dietary treatment. The purpose of this study was to observe the effect of LCn-3PUFA on the secretion of adiponectin in differentiated human preadipocytes and determine if …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
Leptin and adiponectin are the adipokines that are shown to exert pro-hypertrophic and anti-hypertrophic effects respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and …
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Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… depot, adipose tissue is an endocrine tissue. Adiponectin and leptin are two adipokines that control insulin sensitivity and energy balance. In spite of their importance, there are still questions about their secretion. I hypothesized that leptin and adiponectin follow different secretory …
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