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Showing 1 to 20 of 44 for “"Adipokines"”.
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Exploring the influence of adipokines on neuronal function in Alzheimer’s disease
… has shown that adipocytes can actively secrete adipokines and these adipokines may possess the ability to influence AD pathology, but it remains poorly understood how adipokines impact neural functioning. The current study was focused on the potential neuroprotective effect of adipokines on the …
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The Association of Adipokines and Insulin Resistance in Women with Polycystic Ovarian Syndrome
… between measures of insulin resistance and adipokines (leptin, adiponectin, and visfatin) in women with PCOS. Secondarily this study assessed association between adipokines and markers of obesity in women with PCOS. METHODOLOGY: Plasma concentrations of insulin, leptin, adiponectin, and …
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Relationship of the glycation gap to diabetes and its complications, and the potential role of adipokines
… to the release of high level of inflammatory adipokines and this is the link between obesity and CVD. Adipokines are believed to have a role in diabetic complications. This research intends to understand the role some specified adipokines plays in insulin secretions and beta cell failure. …
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The role of adipokines (leptin and adiponectin) and lipids in the interaction between obesity and prostate cancer
… objective of providing an overview of how the adipokines (leptin and adiponectin) and lipid profiles contribute to the interaction between obesity and prostate cancer, with each chapter using a different study design and research question in order to get a more complete picture of how obesity …
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The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases.
… shown that fat cells produce proteins called adipokines which have various influences on the human metabolism and has helped to change the perspectives of researchers on the concept of the adipose tissue being just a store of energy. As a result of this, adipokines have been reported to …
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The effects of the adipocyte-secreted proteins resistin and visfatin on the pancreatic beta-cell
Adipose tissue secreted proteins (adipokines) have been proposed to form a link between obesity and type 2 diabetes (T2D). Resistin and visfatin are two adipokines which have been previously suggested as having roles in the pancreatic islet. The aim of this study was therefore to investigate the …
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Uždegimo žymenų reikšmė ankstyvam ūminio pankreatito eigos prognozavimui: perspektyvinio daugiacentrio kohortinio tyrimo rezultatai /
… the least studied group of predictors are adipokines. Adipokines are cytokines produced in white adipose tissue as well as in peripancreatic fat and involved in inflammatory response. Increase of fatty tissue due to obesity is associated with the amplified systemic inflammatory response in …
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The value of inflammation markers in early acute pancreatitis course prediction: the results of prospective multicenter cohort study /
… the least studied group of predictors are adipokines. Adipokines are cytokines produced in white adipose tissue as well as in peripancreatic fat and involved in inflammatory response. Increase of fatty tissue due to obesity is associated with the amplified systemic inflammatory response in …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… than weight gain. We have identified a number of adipokines linked to MRD risk and weight gain in our patient cohort, these include Leptin, IL-8, pref-1, endocan and adiponectin in weight gain. Also, resistin, serpin A12, IGFBP4, cathepsin-S and Angiopoetin-2 in MRD risk. We have shown that …
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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
… by adipose tissue, collectively referred to as adipokines, remain uncharacterized. We employed bio-orthogonal non-canonical amino acid tagging (BONCAT) and mass spectrometry to comprehensively characterize the secretome of murine visceral and subcutaneous white adipocytes and interscapular brown …
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Altering the ADIPO: LEP Ratio Secreted by Obese Adipose Tissue affects the Tumor Growth Microenvironment of MCF7 Breast Cancer Cells
… depot, we now know it produces and secretes the adipokines adiponectin (ADIPO) and leptin (LEP). Lean individuals have been shown to have higher circulating levels of ADIPO and lower levels of circulating LEP, while the opposite is found in obese individuals, which ultimately alters the ratio …
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The Effect of Aberrant Inflammation During Pregnancy on Subsequent Risk of Maternal Metabolic Disease Development
… disease. Plasma concentration of various adipokines were also measured. Overall, the results of this study did not support the hypothesis, as the animals who experienced a non-inflammatory pregnancy followed by a HFD exhibited the highest instances of metabolic disease development. This …
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Diabetes and Obesity Induce Transcriptomic and Metabolomic Changes Enhancing Pancreatic Cancer Aggressiveness
… array showed an induced secretion of several adipokines in the obese and diabetic mice compared with lean mice. Our co-culture system showed a direct impact of adipocytes on the growth of pancreatic cancer cells. In conclusion, obesity and diabetes have adverse effects that promote pancreatic …
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Molecular aspects of the link between obesity and endometrial cancer.
… studies related to the role of circulating adipokines and inflammatory molecules in EC. Cochrane Central Register of Controlled Trials (CENTRAL), Cinahl, Web of Science, Medline and Embase databases were searched using key words: endometrial cancer, obesity, adiponectin, leptin, …
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Molecular aspects of the link between obesity, insulin resistance and breast cancer.
… of cytokines released from fat tissue, called adipokines. Epidemiologically, the risk of developing postmenopausal breast cancer is increased in obese individuals. The molecular link between obesity and breast cancer however is not well understood. The study presented here aimed at identifying …
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HORMONE AND FLAVONOL REGULATION OF MAMMALIAN METABOLIC SIGNALING PATHWAYS
… the effects of weight loss on secretion of adipokines in an older, obese human population. We asked whether the 2- to 3-fold higher serum leptin levels previously reported in younger women, compared to younger men, were maintained in this older population. The sexual dimorphism of leptin was …
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Physiological and Performance Effects of 11 Weeks of Training in Division 1 Collegiate Throwers: An Exploratory Study.
… hormones (testosterone and cortisol), and adipokines (adiponectin, leptin, and resistin) were taken at weeks 1, 7, and 11. The throwers demonstrated several statistically significant alterations over time for performance variables. The throwers realized increases across time in maximum …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
Leptin and adiponectin are the adipokines that are shown to exert pro-hypertrophic and anti-hypertrophic effects respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and …
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The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity
… endocrine organ that releases a variety of adipokines that affect whole body metabolism. While much research has focused on adipose storage of TG in the past, this dissertation focuses on cholesterol. Adipocytes can account for up to 50% of the body’s free cholesterol storage, but the effect …
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