Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Adipokine"”.
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Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… endocrine tissue. Adiponectin and leptin are two adipokines that control insulin sensitivity and energy balance. In spite of their importance, there are still questions about their secretion. I hypothesized that leptin and adiponectin follow different secretory routes. I found adiponectin …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… work has been designed to identify changes in adipokine profiles at diagnosis and after the intense phase of induction therapy to investigate if dysregulated adipokine profiles contribute to weight gain and MRD risk. To achieve this weight status and BMI was recorded and blood plasma was tested …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
… Increasing visceral adipose tissue augments adipokine secretion provoking an enduring low-grade inflammatory response that negatively impacts on the insulin signalling cascade. In an intervention study of a murine diet-induced model of type 2 diabetes, a novel compound, RTC-1, designed to …
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Serum Omentin As A Potential Biomarker For Complex Atypical Hyperplasia and Endometrioid Endometrial Adenocarcinoma
… cancer. Omentin, a recently discovered adipokine, has been shown to be present in lower levels in patients who are obese and/or insulin resistant. A case-control study was conducted using the serum of 140 women with endometrial cancer and 75 women with endometrial hyperplasia who were …
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Das Adipokin fasting-induced adipose factor/angiopoietin-like protein 4 in Abhängigkeit von der Nierenfunktion
… verschiedene Proteinhormone, sogenannte Adipokine, ausschüttet, welche metabolische und vaskuläre Komplikationen bei pathologisch erhöhtem Körpergewicht direkt beeinflussen. Im Jahr 2000 wurde fasting-induced adipose factor/angiopoietin-like protein 4 (FIAF/Angptl4) als ein neuartiges …
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The Association of Adipokines and Insulin Resistance in Women with Polycystic Ovarian Syndrome
… resistance in women with PCOS is unknown, but adipokine levels may play a role. PURPOSE: The primary purpose of this pilot study was to evaluate the relationships between measures of insulin resistance and adipokines (leptin, adiponectin, and visfatin) in women with PCOS. Secondarily this study …
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Gain And Loss Of Progranulin Have Opposite Effects On Autophagy
… has recently emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity. Individuals with obesity and type 2 diabetes were shown to have increased serum PGRN levels. Heterozygous loss of function mutations in the gene encoding PGRN (GRN) have been described as the …
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Adiporedoxin, an upstream modulator of endoplasmic reticulum oxidative folding and protein secretion
… knock down decreased the secretion of numerous adipokines, extracellular matrix, and transmembrane proteins and over expression increased secretion. Together, these results suggest Adrx regulates an early step in protein secretion from the ER. Immunofluorescence and proteolytic protection assays …
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Transcriptional regulation of adipose insulin resistance
… deciphering the signaling defects and abnormal adipokine secretion profiles. There is increasing awareness that transcriptional control is a source of dysregulation as well as an avenue of therapeutic intervention for insulin resistance. However, knowledge of transcriptional regulation and …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… and one contributing factor is altered adipokines profiles. Adiponectin is the most abundant adipokine in the circulation and a low serum adiponectin level is implicated in multiple diseases. Adiponectin acts on various tissues by improving energy metabolism and conferring protective …
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The role of adipokines (leptin and adiponectin) and lipids in the interaction between obesity and prostate cancer
… objective of providing an overview of how the adipokines (leptin and adiponectin) and lipid profiles contribute to the interaction between obesity and prostate cancer, with each chapter using a different study design and research question in order to get a more complete picture of how obesity …
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Influence of Gender and Aerobic Training Background on Exercise-Induced Increase in Adiponectin
Adipose tissue secretes the adipokine, adiponectin (ADPN), which is insulinsensitizing, anti-inflammatory, and anti-atherogenic. Exercise training improves insulin sensitivity and lowers the risk of cardiovascular complications. As some of the metabolic effects of exercise training and ADPN …
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The role of adiposity in the association of branched-chain amino acids and metabolic and clinical markers in healthy adults on controlled diets.
… and CRP, and (3) markers of BCAA catabolism, adipokines (leptin and adiponectin), and markers of inflammation (CRP, IL-6, and SAA). Adiposity was positively associated with leucine (p=0.043), isoleucine (p=0.035), valine (p=0.034), pyruvate (p=0.015), alanine (p=6e-4), glutamic acid (p=8e-7), …
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Diabetes and Obesity Induce Transcriptomic and Metabolomic Changes Enhancing Pancreatic Cancer Aggressiveness
… AKT/mTOR pathway activation and tumor growth. Adipokine profile array showed an induced secretion of several adipokines in the obese and diabetic mice compared with lean mice. Our co-culture system showed a direct impact of adipocytes on the growth of pancreatic cancer cells. In conclusion, …
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Anti-Insulin Resistance Treatments Suppress Her2+ Breast Cancer Growth Via Altering Metabolism
… Anti-insulin resistance treatments also affected adipokine expression profiles and may reveal potential targets for further research. In conclusion, our results indicate the therapeutic effect of anti-insulin resistance treatments on breast cancer metabolism and this animal model also shed the …
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Influence of dietary interventions on the immune system: an investigation of the impact of omega-3 fatty acids, dietary fermentable materials and high energy diets
… had relatively less influence on cytokine and adipokine profiles associated with diet-induced obesity. Taken together, dietary interventions are capable of subtly influencing varied immune outcomes in animal models and in human subjects, however the interpretation of these dietary influences …
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The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
… pathway, and adiponectin –an insulin sensitizing adipokine, and down-regulates inflammatory cytokine expression. E4orf1 increases glucose uptake in, preadipocytes and adipocytes. In hepatocytes, E4orf1 reduces glucose output and the metabolic studies indicate it favors less hepatic lipid storage. …
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Different dietary approaches for the treatment of obesity and the phenotypic responses to these diets.
… body composition, cardiovascular risk factors, adipokines, liver and kidney function, and health and lifestyle factors were measured. Those with metabolic syndrome were also examined. It was hypothesised that there are alternative ways of treating obese subjects depending on their phenotype. …
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Effects of Growth Hormone on Circulating Resistin Levels in Mice
… proinflammatory hormones collectively known as adipokines. With obesity, the balance shifts towards an increase in proinflammatory hormones. One such adipokine, resistin, is found to have a positive correlation with inflammation and with insulin resistance. The aim of this study was to …
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