Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Adipogenesis"”.
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Mechanisms of pathological adipogenesis
… of the mechanisms underlying pathological adipogenesis in bone may provide interesting therapeutic targets for disorders such as osteoporosis.
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NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM
Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy …
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Mechanisms underlying enhanced bone marrow adipogenesis in diabetes
… we have shown that diabetes enhances adipogenesis in the bone marrow and reduces the number of marrow-resident vascular regenerative stem cells. In this study, I have determined the mechanisms of deleterious bone marrow adipogenesis, which may alter the cellular composition of the …
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Identification of ITGBL1: A Novel Regulator of Adipogenesis
… was a key step forward in understanding adipogenesis (4). Zfp423 regulates the expression of Pparγ, the "master regulator" of adipogenesis. To understand the localization of Zfp423 in vivo, Gupta et al. derived Zfp423GFP BAC transgenic reporter mice, which express GFP under the control of …
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Identification of ITGBL1: A Novel Regulator of Adipogenesis
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Regulation of PPARgamma Activity by mTOR in Adipogenesis
… roles of mTOR were investigated by using an adipogenesis model system. Herein, I show that mTOR plays a critical role in adipocyte differentiation and the maintenance of mature adipocytes, and that its kinase activity is required. Rapamycin specifically disrupted the positive transcriptional …
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Altered regulation of adipogenesis with respect to disease processes
… detailed investigation using the 3T3-L1 in-vitro adipogenesis model. Preliminary investigations carried out identified a complex endogenous IGFBP5 expression profile in 3T3-L1 differentiation, with IGFBP5 over-expression and knockdown leading to inhibited and enhanced differentiation, …
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Adipogenesis and angiogenesis : roles in tissue engineering and glucose metabolism
… lab has previously shown that angiogenesis and adipogenesis are mutually dependent via a VEGF receptor 2 (VEGFR2)-mediated mechanism. Since then several other studies have reinforced a role for the VEGF-VEGFR system in energy metabolism. For example, genetically obese mice treated with anti-VEGF …
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Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis
… signaling was increased in p27KO MEFs during adipogenesis indicating that the pathways of ERalpha/E2 signaling and p27 activity during adipogenesis might be connected. In conclusion these studies have shown that though ERalpha is the major receptor involved in ER/E2 signaling in adipose …
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
Obesity-related comorbidities, including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) have become a major public health concerns. These complications primarily arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat …
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Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… we demonstrated that PGF2α inhibits adipogenesis via activation of the calcium-regulated protein phosphatase, calcineurin. In this current study, we have now extended these findings to identify the IL-11 cytokine and the Nurr1 orphan nuclear hormone receptor as functionally important …
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Adipogenesis and fibrogenesis in muscle and effects of pregnancy and feeding level on carcass meat quality and development of cattle fetus
O presente trabalho foi desenvolvido a partir de três experimentos.O Objetivo do primeiro estudo foi de avaliar a deposição de tecido adiposo intramuscular e colágeno em músculo esquelético de animais da raça Wagyu em comparação com animais da raça Angus. Os animais foram manejados sob mesmas …
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Phytochemical characterization, antioxidant capacity and in vitro inhibition of adipogenesis and inflammation of phenolic extracts in Vaccinium floribundum and Aristotelia chilensis
Made available in DSpace on 2010-05-18T18:55:54Z (GMT). No. of bitstreams: 4 Schreckinger_Maria.pdf: 1346806 bytes, checksum: 7053a5a1eea626464ebc1c3eb3c5e342 (MD5) Schreckinger_Maria.pdf.pdf: 1346806 bytes, checksum: 7053a5a1eea626464ebc1c3eb3c5e342 (MD5) 1_Schreckinger_Maria.pdf: 1349110 bytes, …
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Effect of yerba mate tea caffeine and green coffee by-products on in vitro adipogenesis and lipid accumulation and their incorporation into functional beverages
In addition to its stimulatory effect, caffeine has been also associated with suppressing lipid accumulation and weight gain, making the well established energy drink market an ideal avenue to expand product health functionality. The objective of this study was to evaluate the effect of caffeine …
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FoxO1 in the regulation of adipocyte autophagy and biology
… that excess adiposity may arise from increased adipogenesis (hyperplasia) and adipocyte size (hypertrophy) . Emerging evidence underscores autophagy as an important mediator of adipogenesis and adiposity. We are interested in the upstream regulator of adipocyte autophagy and how it impacts …
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Role of appetite-regulating peptides in adipose physiology in broiler chicks
… Neuropeptide Y (NPY) is orexigenic and promotes adipogenesis in both birds and mammals, although mechanisms in adipose tissue are unclear. The first objective was thus to evaluate effects of NPY on chick preadipocyte proliferation and differentiation. Preadipocytes were treated with NPY and gene …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
… an antagonist of Hh signaling, promoted adipogenesis. Activating or blocking Hh signaling genetically produced similar effects as pharmacological treatment. Additional study in multipotent cell lines, NIH3T3 and C3H10T1/2, reinforced the inhibitory role of Hh signaling in adipogenesis. …
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Investigating Invadolysin's activity: discerning mechanism and cellular roles
… and investigate its role in metabolism and adipogenesis. Invadolysin has a conserved metalloprotease motif ‘HEXXH’ and a potential lipase motif ‘GXSXS’. One of the aims of my PhD was to generate mutant versions of the conserved motifs to study their role on the activity of the proteins. I …
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Estrogen signaling interacts with Sirt1 in adipocyte autophagy
… that Sirt1 suppressed autophagy and reduced adipogenesis and adiposity via inducing mTOR-ULK1 signaling. Specific activation and overexpression of Sirt1 induced mTOR-ULK1 signaling to suppress autophagy and adipogenesis. And knockdown of Sirt1 exhibited opposite effects. The first and second …
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Mechanisms of growth hormone inhibition of adipose tissue growth
… GH inhibits fat tissue growth also by inhibiting adipogenesis. In this study, stromal vascular fraction (SVF) cells were isolated from subcutaneous fat of lit/+ and lit/lit mice and were induced to differentiate into adipocytes in vitro. Oil Red O staining and gene expression analysis revealed …
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