Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 153 for “"Adipocyte"”.
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Transcriptional Regulation Of Adipocyte Function
… result of both hyperplasia and hypertrophy of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte progenitor cells and the development of the adipose organ have not been …
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Effects of Neuropeptide Y on Adipocyte Metabolism
… obesity. However, the role of NPY in regulating adipocyte metabolism is poorly understood. The present study examined the effects of NPY on adipocyte metabolism using 3T3-L1 adipocytes. We found that NPY potentiated isoproterenol (P-adrenergic agonist) stimulated lipolysis. This potentiation …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. Adipocytes also take up fatty acids from the …
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Estrogen signaling interacts with Sirt1 in adipocyte autophagy
… a method to monitor autophagy flux during adipocyte differentiation, which better reflected the dynamic process of autophagy. Compared with preadipocytes, autophagy flux activity was increased in mature adipocytes after differentiation. And then, my thesis project has addressed three main …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… with obesity, the hypertrophic expansion of adipocytes, the main cell type within AT, is not matched by new vessel formation, leading to AT hypoxia. As a result, hypoxia inducible factor-1⍺ (HIF-1⍺) accumulates in adipocytes inducing a transcriptional program that upregulates profibrotic …
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FoxO1 in the regulation of adipocyte autophagy and biology
… from increased adipogenesis (hyperplasia) and adipocyte size (hypertrophy) . Emerging evidence underscores autophagy as an important mediator of adipogenesis and adiposity. We are interested in the upstream regulator of adipocyte autophagy and how it impacts adipocyte biology. Given that …
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Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
Insulin acts on adipocytes to control whole-body lipid and glucose metabolism. Following binding to its receptor on adipocytes, insulin activates a signalling cascade that promotes glucose uptake and inhibits lipolysis. These processes rely on changes in protein localisation. For example, insulin …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
… and function of thermogenic beige and brown adipocytes, lowering energy expenditure and worsening metabolic disease. Beige adipocytes arise within white adipose tissue in response to environmental and hormonal cues, whereas brown adipose tissue is a dedicated thermogenic organ; both depots …
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MicroRNAs: Tissue Expression and Role in 3T3-L1 Pre-Adipocyte Differentiation
… whether microRNAs regulate 3T3-L1 pre-adipocyte differentiation. The expression of microRNAs during 3T3-L1 pre-adipocyte differentiation was detected by microarrays and confirmed by northern blot and quantitative real time PCR. Several microRNAs, including let-7, were up-regulated at …
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The role of adiponectin and the adipocyte in energy metabolism and inflammation
… early in the growth curve. Incubating pig adipocytes for 6 hours with recombinant pig adiponectin also resulted in an approximate 30% reduction (P < 0.05) in lipogenesis compared with adipocytes under basal conditions and with those incubated in the presence of insulin.^ Based on in vivo …
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Investigation of the role of BACE1 in adipocyte and immune cell function
… of BACE1 from either the myeloid cells or adipocytes may mediate the advantageous phenotype of the global BACE1 KO mouse and once the key cell type was identified allow investigation into the mechanism underlying this phenotype. <br/><br/>This project, alongside a parallel study, aimed to …
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Adipocyte hyperplasia and fat deposition in high-weight and low- weight chickens
Four experiments were conducted to compare adipocyte dynamics and body composition among adult chickens from lines differing in growth rate and feed consumption. In Experiment I, forced caloric overconsumption increased weight gain and fat deposition, with concomitant increases in the total …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… exogenous mitochondria into NIH3T3-L1 adipocytes on various aspects of adipocyte function. The key discoveries of this study include a remarkable upregulation of energy expenditure genes, notably Ucp1, Dio2, Ppara, and Ppargc1a, upon exposure to exogenous mitochondria, thereby promoting …
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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
… and many types of cancers. Whereas white adipocytes efficiently store energy in the form of triglycerides, thermogenic brown and beige adipocytes can dissipate energy into heat. Adipose tissue is now considered an important endocrine organ, and increasing evidence suggests that divergent …
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Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays
… adipogenic, and antioxidant status in adipocytes, respectively. Two polyphenolic xanthones, α-mangostin (α-MG) and γ-mangostin (γ-MG) from mangosteen fruit, have been reported to have anti-adipogenic and anti-inflammatory activities. We validated inflammatory and adipogenic properties …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… that age and obesity, conditions associated with adipocyte accumulation in the bone marrow, are linked to increased risk of developing PCa and progressing to metastatic disease. Studies presented in this dissertation were based on the hypothesis that metastatic progression in bone is a result of a …
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Obesity and neuroinflammation : the impact of adipocyte-derived extracellular vesicles on microglial cell signalling
… cell types and aid in cell-cell communication. Adipocyte-derived extracellular vesicles (AT-EVs) are known to be involved in interorgan crosstalk during obesity and therefore may be a key component in obesity induced neuroinflammation.Aim and Hypothesis: To understand the effects of AT-EVs on …
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
… risk and progression, and high accumulation of adipocytes is increasingly recognized as an active facilitator in the interaction between the tumor and the adipose tissue in the breast. Adipocytes may act as a therapeutic obstacle and can be viewed as a target in breast cancer, as they affect …
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