Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 134 for “"Adhesions"”.
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Dissecting interactions within focal adhesions: studies on vinculin
… and paxillin are proteins that localise to focal adhesions. Focal adhesions are<br/>specialised sites of cell attachment between the cytoplasmic side of the cell membrane and<br/>the extracellular matrix. They consist of receptors that link extracellular matrix ligands to<br/>the actin …
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Fibrin targeting microbubbles for the detection of nascent surgical adhesions
Surgical adhesions are fibrous bands of scar tissue that form as a result of surgically induced damage to the peritoneum. Adhesions occur after 95% of abdominal surgeries and can cause severe complications. Currently, there is no non-invasive way to diagnose surgical adhesions. This thesis examines …
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Abdominal vacuum lift as an aid to diagnosing abdominal adhesions
… organs after surgery or infection. These adhesions can cause pain, discomfort , inflammation, anxiety, depression, problems with conception, trouble eating, and decreased immune function. There are around 300,000 hospital admissions in the U.S. every year for patients due to adhesions.. …
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Detection and tracking of cells and focal adhesions in microscopy images
… or their internal structures. For example, focal adhesions moving inside a single migrating normal human epidermal keratinocyte. In particular, the use of the Interacting Multiple Model (IMM) algorithm is proposed given its ability to take into account several different motion models at every …
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Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions
… mechanisms by which fibroblasts release their adhesions to the extracellular matrix substrata using a permeabilized cell system in which the adhesions remain relatively stable. A large number of different molecules were assayed for their effect on focal adhesion stability using …
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Pathogenesis of post surgical adhesions and prevention using a novel fibrin sealant
Post surgical adhesions (PSAs) are an inevitable outcome of surgery and their presence leads to pathogeneses and significant economic impact. The studies within this thesis utilised standard and reproducible abrasion models, in rabbits, pigs and rats, to investigate the formation and maturation of …
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The potential role of innate immunity in the pathogenesis of post-operative adhesions
… positioning of abdominal organs. Consequently, adhesions are major contributors to small bowel obstruction, infertility, and severe pelvic and abdominal pain. Physiological processes responsible for adhesion formation remain obscure though it is believed to involve cell migration, proliferation, …
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Contributions of type 2 IP3 receptors to intercellular adhesions and invasion of glioblastoma cells
… in a 13% increase in looser intercellular adhesions. To identify candidate proteins that could contribute to reduced intercellular adhesion after loss of IP3R2, I optimised two unbiased approaches, mass spectrometry (MS) and RNA-sequencing (RNA-seq). U87-MG cells treated with IP3R2 shRNA or …
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Pratiques de bullying et adhesions normatives dans quelques classes d'école et de college en Italie
School bullying: does the study of peer harassment in schools delve deeper into the relationships of young people with rules and values? What are the key factors that can help to better identify and understand the phenomenon ? The work starts from a re-definition of school bullying based on the …
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Treatment of prepubertal labial adhesions: a randomized, double-blinded trial comparing topical emollient versus topical estrogen
Labial adhesions are a common finding estimated to occur in 22% of prepubertal girls. Symptoms are related to the accumulation of urine behind partially fused labia and include urinary tract infections, vulvovaginitis, pain with activity, post-void dripping of urine, and, in cases of complete …
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Dynamics of Alpha5 Integrin, Paxillin, and Alpha-Actinin During Formation and Disassembly of Adhesions in Migratory Cells
In this study, I have probed the mechanisms of eukaryotic cell migration by fusing the genes encoding proteins involved in cell migration to the gene for a green fluorescent protein, GFP. I ascertained that the novel fusion protein expressed by cells transfected with alpha5-GFP is correctly …
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Differently charged polypeptides and their impact on peritoneal and pleural postoperative adhesion formation
… adhesion formation Abstract: Abdominal adhesions are formed after previous peritoneal traumas where previous surgery poses the most frequent cause. An increasing number of clinical complications due to adhesions have been detected such as small bowel obstructions, female infertility, and …
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Synechia vulvae v dětském věku - informovanost rodičů o problematice a prevenci
The bachelor's thesis deals with labial adhesions in childhood, parents' awareness of this issue and parents' awareness of prevention options. Synechia vulvae is formed by the joining of the opposite edges of the mucous membrane of the vaginal entrance or labia minora, exclusively on the genital …
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A study of keratinocyte differentiation and adhesion in vitro
… by the formation of cadherin-mediated cell-cell adhesions. The likely importance of the cadherin-mediated adhesions in initiation the differentiation program was confirmed in two ways. Firstly, clustering cell-surface E-cadherin in low extracellular calcium using monoclonal antibodies increased …
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Cell Mechanics: From Cytoskeletal Dynamics to Tissue-Scale Mechanical Phenomena
… matrix depth and stiffness, strength of focal adhesions and makes experimentally testable predictions. In part (c) we combine experiment and theory to reveal how intercellular adhesions modulate forces transmitted to the extracellular matrix. We find that In the absence of cadherin-based …
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… for carcinoma progression, as loss of cell-cell adhesions supports proliferation, aberrant signaling, epithelial-to-mesenchymal transition, invasion, and metastasis. The present work provides strong evidence that CD73-generated adenosine actively promotes cell-cell adhesion in carcinoma cells by …
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Mechanisms of cell adhesion regulation by herpes simplex virus
… and sites of cell-matrix adhesion termed focal adhesions. All three proteins are required for efficient virus assembly, egress and cell-to-cell spread. However, the viral or cellular binding partners required for these functions have not yet been fully identified. Furthermore, very little is …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
… cell-cell junctions and reduced focal adhesions. Endothelial polarity is also rapidly lost upon Cdc42 deletion, as seen by failed localization of apical podocalyxin (PODXL) and basal actin. We link observed failures to a defect in F-actin organization, both in vitro and in vivo, which …
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