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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Adenoviruses."”.
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Investigating the epidemiology of adenoviruses in free-ranging turtles in Illinois
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Investigating the epidemiology of adenoviruses in free-ranging turtles in Illinois
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Mucosal and systemic immune responses induced by immunisation of cotton rats with recombinant adenoviruses
… efficacy of immunisation with these recombinant adenoviruses in conferring protection against BHV-1 infection, a cotton rat (Sigmodon hispidus) model for intranasal BHV-1 challenge was developed. I used this model to assess the ability of different routes of immunisation with the recombinant …
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Human Adenoviruses As Indicators Of Faecal Contamination And Pathogen Indices In The Environment And Shellfish
… aim of this study was to assess the use of human adenoviruses (HAdVs) as occurrence indicators of human enteric viruses in the environment and shellfish. The second aim was to consider human polyomaviruses (HPyVs) for the same roles. To gain a better understanding of the ecology of HAdV, their …
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
<p>Glioblastoma is the most common malignant primary brain tumor in adults; the current aggressive treatment results in a 5% five-year survival rate. More effective therapies should be developed. One promising alternative is oncolytic adenovirus, Delta-24-RGD, which elicits cancer cell lysis and …
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Kinetics and Mechanisms of Human Adenovirus 2 Inactivation With UV and Chlorine
… to potable water. Of particular interest are adenoviruses, which are on the CCL2 issued by the EPA. Unfortunately, the recently-adopted method of irradiation by ultraviolet (UV) light is largely ineffective against adenoviruses. Research is therefore required to find whether any of the other …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… immunotherapy with recombinant, oncolytic adenoviruses is under investigation for the treatment of cancer. Evidence indicates adenoviruses induce autophagy that is required for oncolysis, but the molecular regulation of autophagy in infected cells remains under investigation. Our data …
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Construction of bovine adenovirus type 3 E1 and E3, substitution plasmids and the sequencing analysis of DNA pol and pTP /
The relative ease to concentrate and purify adenoviruses, their well characterized mid-sized genome, and the ability to delete non-essential regions from their genome to accommodate foreign gene, made adenoviruses a suitable candidate for the construction of vectors. The use of adenoviral vectors …
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Hepatitis B Virion and cccDNA Formation in Primary Tupaia Hepatocytes and Human Hepatoma Cell Lines upon HBV Genome Transduction with Replication-defective Adenovirus Vectors and in vivo Infection of Tupaias
… and adult tupaias were infected with recombinant adenoviruses by intravenous injection. In two of the newborn animals, HBV antigens and HBV virions were detectable for more than 4 months. As in transduced PTHs, in vivo infection was dose dependent and subject to dynamic changes. It seems that …
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Characterization of Avirulent Turkey Hemorrhagic Enteritis Virus: A Study of the Molecular Basis for Variation in Virulence and the Occurrence of Persistent Infection
… found that distinguish this genus from all other adenoviruses, and differences were found that possibly contribute to host specificity of the members. The VAS is known to stimulate a life-long protective antibody response, though viral replication is only of short duration. Several studies were …
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Functional genomics in the stroke-prone spontaneously hypertensive rat: genome wide and candidate gene analysis
… in reduced SHRSP Gstm1 expression. Recombinant adenoviruses expressing Gstm1 and short-hairpin RNA-interference sequences to reduce Gstm family expression were produced. In-vivo overexpression of Gstm1 did not improve endothelial nitric-oxide bioavailability in SHRSP carotid arteries. Bacterial …
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UNDERSTANDING THE RELATIONSHIP BETWEEN ONCOLYTIC AD5 DELETED E1b55KDA LYTIC INFECTION AND P53 IN MAMMALIAN CELLS
Adenoviruses are the most commonly used in the development of oncolytic therapy. Oncolytic adenoviruses are genetically modified to selectivity replicate in and kill tumor cells. The p53 molecule is a tumor suppressor protein that responds to viral infection through the activation of apoptosis, …
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Structure of the GP16 ATPase from the φ29 dsDNA packaging motor
… viruses such as poxviruses, herpesviruses and adenoviruses. Encapsidation of bacteriophage φ29 DNA is driven by a phage-encoded molecular motor. This motor is powered by an oligomeric ATPase, gp16, or gene product 16, that converts energy obtained from ATP hydrolysis into translocation of …
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Economic evaluation of using adenovirus type 4 and type 7 vaccines in United States military basic trainees
Adenoviruses, particularly types 4 and 7, are associated with febrile respiratory illness (FRI) outbreaks in US military basic trainees. Vaccines against these two serotypes controlled FRI in basic trainees until production ceased in the mid-1990s. After contracting a new manufacturer, adenovirus …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… processing by use of GSN expressing adenoviruses (AdVs). Use of a non-cleavable GSN-AdV provided evidence for not only the requirement of GSN in the hypertrophic response, but also for caspase mediated GSN cleavage. This body of work implicates caspase pathways and their targets as …
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Advances in Bone Tissue Engineering
… RNA. In study III, MSCs were transduced with adenoviruses to express BMP2 and VEGF. An interesting interaction was discovered, where VEGF was shown to inhibit simultaneous BMP2 expression. In study IV, a periosteum-like graft was engineered, using the dermal matrix AlloDerm and seeded MSCs. …
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OAdV7, an ovine adenoviral vector as a novel vaccine vector for tumour immunotherapy
Adenoviruses are a large family of non-enveloped DNA viruses with the ability to efficiently transduce human cells and activate the innate immune system, making them one of the most popular viral vectors for vaccine development. To date, the majority of the studies in the literature have focused …
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Arrhythmogenic mechanisms of acute cardiac infection
… pathogen. However, it is not understood how adenoviruses cause sudden cardiac arrest. Myocarditis is defined by two phases, acute and chronic. The acute phase involves viral-mediated remodeling of subcellular structures in the myocardium, which is thought to contribute to arrhythmogenesis. …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… We hypothesized that protecting oncolytic adenoviruses from humoral and cellular immunity to viral antigens will enhance the effectiveness of virotherapy. Here, we utilized sera obtained from patients who underwent a completed clinical trial with Delta-24-RGD for recurrent malignant gliomas …
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