Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Adenovirus vector"”.
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Developing SINrep5 as a Viral Vector Platform to Test SARS-CoV-2 Vaccine Candidates
… One particular vaccine of interest is the adenovirus vector-based vaccine, which has raised apprehension since its use against SARS-CoV-2. Public hesitation and unclear human-use risks surrounding adenovirus vector vaccines have warranted exploration into other vectors—not just as …
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Strategy for speedy field diagnosis and control of avian influenza viruses (AIV) outbreak at the point of contact/care (POC)
… to transport the samples to a laboratory. The Adenovirus vectors are known as suitable recombinant vaccine vectors because they are capable of infecting a wide variety of cell types, can grow to high titres in vitro, and cannot integrate in the host genome. Due to these features, the Adenovirus …
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Characterisation and analysis of the NS1 gene of tick-borne encephalitis virus
… the CMV IEP/NS1 fragment used as the basis of an adenovirus Eta deletion mutant. The novel combination of the cytomegalovirus immediate- early promoter and the adenovirus vector produced extremely high levels of NS1 expression in cells which do not support the replication of the adenovirus …
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The role of Xist RNA in the maintenance of X chromosome inactivation
… Xist mutation were cultured and infected with an adenovirus vector carrying the gene for Cre recombinase. After Cre mediated deletion of Xist, the inactive X remained transcriptionally silent, late replicating, and hypoacetylated on histone H4, confirming that X-inactivation can be maintained in …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… a 2-dose strategy utilizing either 2-doses of an adenovirus vector (Ad5-YFV) or a heterologous strategy utilizing Ad5-YFV and a live-attenuated (LMA) vaccine were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA at once was also …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… a 2-dose strategy utilizing either 2-doses of an adenovirus vector (Ad5-YFV) or a heterologous strategy utilizing Ad5-YFV and a live-attenuated (LMA) vaccine were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA at once was also …
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Role of viral vectors in candidate HIV vaccine-induced immune responses
… trial, which utilized the recombinant canarypox vector ALVAC, demonstrated moderate, short-term efficacy, while multiple trials utilizing the recombinant human adenovirus vector Ad5 either demonstrated no efficacy or transiently increased the risk of HIV infection in vaccine recipients with …
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Investigating the role of apoptosis regulator EndoG on exogenous DNA uptake, stability, replication and recombination
… such as plasmid DNA (pDNA) and viral DNA vectors, considering their importance in gene therapy applications. The effects of EndoG knockdown on pDNA stability and levels of encoded reporter gene expression were evaluated in the cervical carcinoma HeLa cells. Transfection of pDNA vectors …