Global ETD Search
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Showing 1 to 9 of 9 for “"Adenosylmethionine Decarboxylase"”.
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The Role of S-Adenosylmethionine Decarboxylase on Regulation of Polyamine and Trypanothione Metabolism in Trypanosoma Brucei
… drug targets. We have characterized T. brucei S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme required for the synthesis of spermidine and trypanothione, and examined the role of AdoMetDC on the regulation of polyamine and trypanothione metabolism. The recombinant T. brucei AdoMetDC …
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Polyamine metabolism in Arabidopsis: Transgenic manipulation and gene expression
… manipulation of polyamines via a mouse ornithine decarboxylase (mODC) gene on plant metabolism. (2) To analyze the spatial and temporal expression patterns of Arabidopsis thaliana S-adenosylmethionine decarboxylase genes (AtSAMDC3, AtSAMDC4 and AtSAMDC5) during its life cycle.</p><p>The major …
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Characterization of the expression profile of polyamine biosynthetic genes (Spermidine synthase) and polyamine metabolic regulation in arabidopsis
… other biosynthetic enzymes (mouse ornithine decarboxylase or Plasmodium falciparum ornithine decarboxylase/S-adenosylmethionine decarboxylase) altered spermidine/spermine content much, which indicates a complex and tightly regulated machinery for higher polyamine homeostasis. The turn-over …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… reiterates the activation and regulation of S-adenosylmethionine decarboxylase by a catalytically dead paralog (AdoMetDC prozyme) in the trypanosomatids, and remarkably, it has independently evolved for two enzymes within the trypanosomatid spermidine biosynthetic pathway. T. brucei seemingly …
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The development of a molecular chaperone-based system to improve the heterologous production of Plasmodium falciparum AdoMetDC protein in E. coli.
S-Adenosylmethionine decarboxylase/ornithine decarboxylase from Plasmodium falciparum (PfAdoMetDC/ODC) has been described as an ideal antimalarial drug target. However, the production of this large bifunctional protein to facilitate its biochemical characterization is hampered by the poor yields of …
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Effects of co-expression of chaperone combinations on production of soluble plasmodial protein PfAdoMetDC in E. coli
Plasmodium falciparum S-adenosylmethionine decarboxylase (PfAdoMetDC) plays an important role during the synthesis of polyamines, such as putrescine, spermidine and spermine. Polyamines play a major role in the survival of the malaria parasite. They are critical components of cell growth and …
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Characterization of molecular functions of polyamines in fruit development and ripening in tomato (Solanum lycopersicum)
… yeast spermidine synthase (ySpdSyn) or S-adenosylmethionine decarboxylase (ySAMdc) under constitutive CaMV 35S and/or fruit-specific SlE8 promoters. The ySpdSyn-expression enhanced PUT, SPD and SPM level in floral buds and fertilized developing ovaries by 2- to 3-fold compared to WT …
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Characterization of molecular functions of polyamines in fruit development and ripening in tomato (Solanum lycopersicum)
… yeast spermidine synthase (ySpdSyn) or S-adenosylmethionine decarboxylase (ySAMdc) under constitutive CaMV 35S and/or fruit-specific SlE8 promoters. The ySpdSyn-expression enhanced PUT, SPD and SPM level in floral buds and fertilized developing ovaries by 2- to 3-fold compared to WT …
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Variation in peach fruit susceptibility to Monilinia laxa and gene expression
… Pru P1, an harpin inducing protein and S-adenosylmethionine decarboxylase were found, conversely among the down-regulated ones, cinnamyl alcohol dehydrogenase, an histidine- containing phosphotransfer protein and the ferritin were found. The microarray experimental results and the data …