Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Adenosine receptors"”.
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Adenosine receptors in cutaneous thermal hyperemia and active vasodilation in humans
… it remains unclear as to the source of NO. Adenosine receptors induce vasodilation in many human tissues and may work, in part, through NO. As these receptors are also known to be located in the cutaneous vasculature, the studies contained in this thesis were designed to investigate a …
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Modulation as an Acidosis-Evoked Current by A1 Adenosine Receptors in the CA1 Region of the Mouse Hippocampus
… independent of glutamate receptor activation. Adenosine is released during periods of metabolic stress and exerts a neuroprotective role mediated by adenosine A1 receptor stimulation. The purpose of this project was to study the effect of adenosine A1 receptor stimulation in an in vitro model …
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Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract
… showed that activation of NTS A<sub>1</sub> adenosine</p> <p>receptors yields variable hemodynamic responses with prevailing pressor and iliac</p> <p>vasoconstrictor responses. These responses are accompanied with differential</p> <p>activation of regional sympathetic activity …
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ΥΠΟΔΟΧΕΙΣ ΑΔΕΝΟΣΙΝΗΣ. ΕΠΙΔΡΑΣΗ ΝΟΥΚΛΕΟΤΙΔΙΩΝ ΤΗΣ ΓΟΥΑΝΟΣΙΝΗΣ ΚΑΙ ΔΙΣΘΕΝΩΝ ΜΕΤΑΛΛΩΝ
… OF GUANOSINE NUCLEOTIDES AND DEVALENT CATIONS ON ADENOSINE RECEPTORS. THE BIOLOGICAL SYSTEM THAT HAS BEEN USED WAS RAT AND MOUSE MEMBRANE HOMOGENATES. WE USED BINDING ASSAY METHODS TO STUDY THE BINDING CHARACTERISTICS OF STABLE TRITIADED ADENOSINE ANALOGS THAT HAVE BEEN PROPOSED AS A1 AND A2 …
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Adenosinergic modulation of hippocampal gamma oscillations: from single cell to whole animal
… have been linked to higher cognitive functions. Adenosine receptor modulation has been shown to alter cognitive function in animals and humans. In this thesis the effects of adenosine receptor modulation on in vitro and in vivo hippocampal gamma oscillations were investigated as well as the …
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The Effects of Nucleus Accumbens Opiate and Adenosine Receptor Activity on Appetitive Operant Learning
… Systemic manipulations of the opioid and adenosine receptor pathways influence learning in several different paradigms. Manipulations of both of these receptors within the nucleus accumbens affect motivational aspects of instrumental conditioning and food intake. The nucleus accumbens has …
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Mechanisms Mediating Modulation Of The Cardiopulmonary Chemoreflex Control Of Regional Sympathetic Outputs By Adenosine A1 And A2a Receptors In The Nts
… <p>Degree: Doctor of Philosophy</p> <p>Adenosine is an important neuromodulator of cardiovascular control at the level of the nucleus of the solitary tract (NTS) where cardiovascular and other autonomic reflexes are primarily integrated. Levels of adenosine increase in the NTS during …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
… study demonstrated the correlation between the adenosine signaling pathway and BBB breakdown, highlighting the modulatory role of A2A and A2B adenosine receptors. In conclusion, association of an antibiotic therapy with a drug able to block the VEGFR-1 on pericytes could represent a novel …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
P1-receptors, or adenosine receptors, and P2Y receptors, are G-protein-coupled receptors, belonging to the purinergic receptor family. Adenosine is the natural ligand of the P1 receptors, while P2Y receptors are activated by nucleotide ligands (ATP,ADP, UTP and UDP). The adenosine receptors (P1) …
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Drug discovery at class A and class B GPCRs
G protein-coupled receptors (GPCRs) are a big family of membrane receptors encoded by more than 800 genes in humans. The vast number and diversity of GPCRs enables them to interact with an equally great number of ligands enabling them to regulate many physiological functions such as senses, …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… similar properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been …
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The Role of Adenosine Signaling In Mature Erythrocytes and Erythroid Progenitors
<p>Adenosine is a ubiquitous nucleoside in almost all the cells throughout our bodies. It is highly induced particularly under hypoxia or energy depletion conditions. Adenosine functions as a critical ligand, after binding to membrane-associated adenosine receptors, adenosine initiates a downstream …
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Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids
… OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine receptors differently contribute to …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through interaction with four G-protein coupled adenosine receptors: A1R, A2AR, A2BR, and A3R. However, …
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Factors influencing the responsiveness of human bronchi
… the pharmacological characterization of adenosine receptors, the effects of brain natriuretic peptide, the influence of lipopolysaccharide, the role of hyperglycemia, the activity of vasoactive intestinal peptide receptors and the influence of phosphodiesterase 3/4 enzymes and their …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… a novel immunosuppressive pathway, called adenosine pathway, has been suggested to contribute to the ability of PDAC to evade the immune system and its resistance to immunotherapies (IOT) and cytotoxic treatments, by generating extracellular adenosine (eAdo) as a consequence of the …
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The effects of caffeine and caffeine withdrawal on measures of mood, cognition, and functional magnetic resonance imaging
… that exerts its effects by antagonizing adenosine receptors in a competitive fashion. Caffeine has been considered to have net benefits on mood, reaction time, and cognitive performance. However, chronic caffeine use can result in tolerance to some of its stimulant effects and symptoms of …
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NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)
… shown to be released, including serotonin and adenosine. Previous research has shown the effects of these neuroactive agents on seizure and respiratory function independently. A role of adenosine in triggering death post-seizures in a chemically-induced seizure model has been shown, but the …
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Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2B Signaling
… metabolic energy currency. Patients who lack adenosine deaminase (ADA), the enzyme that irreversibly metabolizes adenosine, have high levels of adenosine that yield severe health problems, including HL; however, the pathogenic mechanisms behind HL and adenosine remain elusive. Our lab has …
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Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… of extracellular Κ⁺, b) the activation of NMDA receptors and c) the application of 10μΜ Adenosine (endogenous substance with antiepileptic properties). Epileptic mice (tg/tg) and phenotypically normal controls (tg/+ or +/+) were used for all the experiments (1 and 2), which employed respectively …
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