Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Adenosine receptor"”.
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Synthesis towards synthetic adenosine receptor
Adenosine is a biologically important molecule as it acts as local modulator with cytoprotective function in the body. Adenosine accumulates in the extracellular space in response to metabolic stress and cell damage, and elevations in extracellular adenosine level are found in conditions like …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through interaction with four G-protein coupled adenosine receptors: A1R, A2AR, A2BR, and A3R. However, …
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The Effects of Nucleus Accumbens Opiate and Adenosine Receptor Activity on Appetitive Operant Learning
… Systemic manipulations of the opioid and adenosine receptor pathways influence learning in several different paradigms. Manipulations of both of these receptors within the nucleus accumbens affect motivational aspects of instrumental conditioning and food intake. The nucleus accumbens has …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… similar properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
… development of atherosclerosis. The release of adenosine at sites of inflammation represents an endogenous mechanism for limiting excessive inflammation and tissue damage. The majority of the anti-inflammatory effects of adenosine are mediated by signalling through the A2AAR and activation of …
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Adenosine receptors in cutaneous thermal hyperemia and active vasodilation in humans
… it remains unclear as to the source of NO. Adenosine receptors induce vasodilation in many human tissues and may work, in part, through NO. As these receptors are also known to be located in the cutaneous vasculature, the studies contained in this thesis were designed to investigate a …
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Adenosinergic modulation of hippocampal gamma oscillations: from single cell to whole animal
… have been linked to higher cognitive functions. Adenosine receptor modulation has been shown to alter cognitive function in animals and humans. In this thesis the effects of adenosine receptor modulation on in vitro and in vivo hippocampal gamma oscillations were investigated as well as the …
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The effects of theophylline on the in vitro respiratory response to hypoxia
… nonselective phophodiesterase inhibitor and adenosine receptor antagonist, on the hypoxic ventilatory response. Brainstem slices are isolated from neonatal mice (4-8 days old) and superfused with artificial cerebrospinal fluid (aCSF), equilibrated with a hyperoxic gas mixture (95% O_2, 5% …
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Hypoxic immunomodulation results in increased disease risk and altered behavior via non-canonical pathways
… potential activators such as K+ efflux and A2A adenosine receptor were administered. After glyburide (K+ efflux antagonist) and 3,7-dimethyl-1-prop-2-ynyl-purine-2,6-dione (DMPX-A2A adenosine receptor antagonist) administration, both drugs significantly reduced the level of caspase-1 activation …
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
… in GBM is homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene, which occurs in 50% of all GBM cases. Despite its common occurrence, it is unclear what contribution MTAP loss makes in the pathogenesis of GBM or whether this genetic alteration can be used as a therapeutic …
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The Effect of Adenosine on the Production of Inflammatory Mediators By Macrophages in Response to Candida Albicans
… factor alpha (TNF-α) and interleukin 1 (IL-1). Adenosine is an important physiological molecule that can modulate the function of macrophages by altering the amounts of cytokine produced. The effect of adenosine on the production of TNF-α and IL-1 by peritoneal macrophages was studied. Murine …
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
<p>Adenosine A<sub>2B</sub> receptor (A<sub>2B</sub>R) appear to contribute to chronic inflammation. This receptor is highly expressed in macrophages and cardiac fibroblasts, cells which play key roles in inflammation and healing following myocardial infarction (MI). A<sub>2B</sub>R have been shown …
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Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids
… OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine receptors differently contribute to …
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… disease. The purinergic pathway’s generation of adenosine and its activation of the adenosine receptor A2B (A2BR) induces cell-cell adhesion to promote barrier function. This barrier function is known to be important in maintaining homeostasis during hypoxia, trauma, and sepsis. Loss of this …
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Role and Regulation of Sphingosine 1-Phosphate In Erythrocyte
… role of erythrocyte Sphk1/S1P in SCD. Elevated adenosine, a signaling molecule induced by hypoxia, increases erythrocyte Sphk1 activity in normal and sickle erythrocytes by activating the A2B adenosine receptor (ADORA2B) which then leads to activation of protein kinase A (PKA) and Extracellular …
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Mechanisms Mediating Modulation Of The Cardiopulmonary Chemoreflex Control Of Regional Sympathetic Outputs By Adenosine A1 And A2a Receptors In The Nts
… <p>Degree: Doctor of Philosophy</p> <p>Adenosine is an important neuromodulator of cardiovascular control at the level of the nucleus of the solitary tract (NTS) where cardiovascular and other autonomic reflexes are primarily integrated. Levels of adenosine increase in the NTS during …
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Exploring the molecular signatures of the ligand-receptor-Gi/o protein interactions of adenosine A1 and A3 receptors
Human adenosine A1 receptor (hA1R) and adenosine A3 receptors (hA3R) are two closely related class A Gi/o-coupled receptors. Both of them represented valuable therapeutic targets and various types of ligands have been developed for regulating their activities. hA1R has important implications in …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
… mice that expressed inhibitory DREADDs—designer receptors that are activated only by otherwise inert ligands—only in dopamine transporter (DAT) or A2A adenosine receptor (A2A) expressing neurons, allowing us to transiently inhibit either DA-releasing neurons (DATcre/DREADD) or striatopallidal …
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Sex differences in the cardiac beta-adrenergic receptor contractile response
… present following menopause. &beta-adrenergic receptors are pharmaceutical targets in the treatment of cardiovascular disease, and sex differences in &beta-adrenergic responsiveness have been demonstrated. However, limited studies have addressed the mechanism(s) underlying these differences. To …
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