Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Adenosine Monophosphate"”.
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Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
Platelet activation is a critical physiological event, whose main role is to prevent excessive blood loss and repair vessel wall injuries. However, platelet activation must be controlled to prevent unwanted and exaggerated responses leading to the occlusion of the blood vessel. The …
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Adenosine monophosphate-activated protein kinase regulates reward regions of the brain during cocaine sensitization
… disrupts brain metabolism by depleting ATP (adenosine triphosphate) production. Given that adenosine monophosphate-activated protein kinase (AMPK) regulates ATP levels, it is worth investigating if cocaine disrupts its normal function. Previous studies showed changes in AMPK activity, marked …
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Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors
The alteration of intracellular cyclic adenosine monophosphate (cAMP) levels plays important regulatory roles in both physiological and pathological conditions, such as cancer. As the most aggressive form of brain tumour, glioblastoma is currently incurable due to limited treatment modalities. Low …
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Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors
Studies were undertaken to examine regulation of progesterone receptor gene expression and estrogen receptor bioactivity in uterine cells, and to determine the cellular mechanisms through which various factors mediate regulation of these receptor proteins. Exposure of uterine cells maintained in …
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Direct Measurements of the Effects of Cyclic Adenosine Monophosphate, and Related Compounds, on Membrane Conductances, Intracellular Calcium and Ph in Gastropod Neurons (cyclic-Amp)
… effects of intracellular injections of cyclic adenosine monophosphate (AMP) and related compounds were examined in identifiable gastropod neurons. Injecting cyclic AMP (or cyclic GMP) in amounts which should have elevated the internal concentration from 0.1-7.6 mM (mean = 3.3 mM) resulted in …
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ΜΕΛΕΤΗ ΣΥΠΛΟΚΩΝ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5' - ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ
IN THIS THESIS THE INTERACTION OF METAL IONS WITH ADENOSINE MONOPHOSPHATE, 6-MERCAPTOPURINE AND ITS RIBOSIDE - ANTICANCER DRUGS - AND 8-AZAPURINES IS INVESTIGATED. WE HAVE PREPARED THE COMPLEXES OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. …
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Exploring Zirconia as a Column Packing Material
… and analysis of phosphorylated proteins. Adenosine triphosphate, Adenosine diphosphate and Adenosine monophosphate were used as prototypes for phosphorylated proteins. Separation, absorption, fluorescence and SEM studies were performed to determine the adsorption of Adenosine phosphates …
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Studies on the mechanism of action of thyroid hormones
Inosine monophosphate (IMP) is a precursor of the two purine nucleotides, adenosine monophosphate (AMP) and guanosine monophosphate (GMP)e through DEAE-Scphacex, and the reaction IMP~ XMP is catalyzed by: IMP dehydrogenase which was purified in a manner similar to adenylosuccinate synthetase. …
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In Pursuit of a Molecular Fountain of Youth: The Identification and Characterization of Lifespan Regulators in Drosophila
… to humans. Next, we identified the two key adenosine monophosphate (AMP) biosynthetic pathways as regulators of Drosophila longevity. We found that heterozygous mutation of anabolic components of the de novo as well as the salvage AMP biosynthesis pathways extend lifespan. These pathway …
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A Study of the Adrenergic Receptors in Mammalian Tracheal Smooth Muscle
… cortisol, no increase in tissue cyclic 3‘,5'-adenosine monophosphate (cyclic AMP) levels was found over those levels measured in tracheas incubated with sodium succinate as a control. It was concluded that, under the conditions studied, the mechanical activity produced by catecholamines on …
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The Physiological and Biochemical Understanding of 5’-Amp Induced Deep Hypometabolism
… deep hypometabolism (DH) via an injection of adenosine monophosphate (5’-AMP) followed by placement in an ambient temperature (Ta) around 15oC currently can last about 3-9 hours. While we have insight into how 5’-AMP induced hypometabolism is initiated, it remains unclear how arousal from …
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The relationship between two forms of glycogen phosphorylase in Dictyostelium discoideum
… ’a' form (the active form) is independent of 5′adenosine monophosphate (5′AMP) while the activity of the ’b' form (the inactive form) is 5′AMP dependent, The two forms are developmentally regulated. Polyclortal antibodies raised to the purified forms of this enzyme show low cross reactivity. The …
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THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE
… soma, the BDNF/TrkB complex activates cyclic Adenosine Monophosphate (cAMP) response element binding protein (CREB), leading to transcriptional changes that support neuron dendrite growth and survival. Using a skeletal muscle-synthesized BDNF deficient mouse model, this thesis aims to assess …
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The role of reactive nitrogen species and aged garlic extract on platelet function
… within platelets, including calcium and cyclic adenosine monophosphate (cAMP). The effect of AGE upon the other cyclic nucleotide, cyclic guanosine monophosphate (cGMP) is currently unknown. The aims therefore of this project are to identify the effect of AGE upon platelet cGMP, as well as …
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In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation
… chorionic gonadotropin (hCG) and 3' 5', cyclic adenosine monophosphate ( cAMP) on porcine placental and endometrial production of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. Duplicate 300 mg samples of placenta, endometrium or both (co-incubation) …
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Radiation Sensitization of Breast Cancer Cells by Vitamin D Through the Promotion of Autophagic Cell Death
… were able to demonstrate a potential role of 5' adenosine monophosphate-activated protein kinase in the sensitization of breast tumor cells to radiation by vitamin D3 as well as cytotoxic autophagy.
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Anthrax toxin effects on B lymphocyte function
… adenylyl cyclase that forms 3’,5’-adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This enzymatic reaction causes an increase in intracellular cyclic AMP (cAMP) in host cells. As cAMP is a prominent second messenger in cellular signaling, edema toxin has a wide …
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Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
… in IGF-1 and possible inhibition related to 5`-adenosine monophosphate-activated protein kinase (AMPK) activation. Specific aim 2 examined the regulation of protein degradation during the progression of cancer cachexia. Proteasomal regulated protein degradation was induced during initial stages …
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