Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Adenomatous Polyposis Coli Protein"”.
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Novel interactions and functions of the Adenomatous polyposis coli protein
Mutations of the Adenomatous polyposis coli (APC) gene are a frequent and early event in the development of sporadic colorectal cancer and also form the genetic basis of familial adenomatous polyposis. APC is an established regulator of the cytoskeleton, however, the tumour suppressive function of …
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Effects of Omega-3s and Vitamin E Prophylactic Diets and the Implications of Lipid Transport in Spinal Cord Injury
… were increased at 7 days post-injury and its protein levels remained constant despite neuronal and oligodendrocyte loss. We observed the highest IR in motor neurons of the ventral gray matter and mature oligodendrocytes expressing the adenomatous polyposis coli protein (APC). Quantitative …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …