Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Adaptors"”.
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Substrate specificity of [alpha]-proteobacterial N-end rule adaptors
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.
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Isolation of GCN5 and ADA5 in a selection for transcriptional adaptors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… are organized by many types of trafficking adaptors. These include the heterotetrameric adaptor protein complexes (APs) and the monomeric Golgi-localized, gamma-ear containing, Arf-binding proteins (GGAs). The fundamental question of how these adaptors are recruited to TGN membrane remains …
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Simultaneous Delivery of CRISPR/Cas Complexes and Donor DNA Using Cell-Penetrating Peptide-Adaptors
<p>Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/CRISPR associated protein (Cas) complexes are becoming the preferred technique for genomic editing because of their precision, efficiency and accuracy. Prokaryotes naturally use CRISPR/Cas complexes to detect and eliminate foreign …
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Understanding the Innovation of Utilizing Universal Design for Learning in Integrated STEM Classrooms by Early Adaptors
Integrated STEM education and Universal Design for Learning (UDL) have been often theorized as compatible. However, there has been little research done to understand how UDL is used in real-world integrated STEM classrooms. Our study aimed to understand how current practicing educators in …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
T cells are an important part of the adaptive immune system, as they are able to specifically recognize foreign agents and generate responses based on the nature of the recognized agent. In addition, they are responsible for the maintenance of cellular tolerance and homeostasis. T lymphocytes need …
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Interaction between the AAA+ protease CIpXP and the adaptor protein SspB
… tags or degrons. Accessory proteins called adaptors can also modulate substrate selection by proteases. These adaptors have the potential to affect substrate specificity as well as expand the repertoire of substrates that can be degraded by proteases. Understanding how proteases interact …
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The Rebel Leader: A Sequential Explanatory Mixed Methods Analysis of Rebel Superintendents in Suburban Public Schools
… three were identified as mild to moderate adaptors; and, three superintendents were identified as mild innovators. The mild innovators group served as a control group for comparison. No participants were identified as high adaptors in this study.</p><p>Superintendents who scored as high …
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Recalled to Life: Adaptations of Charles Dickens for Children and Young Adults
… young adults. I argue that Dickens’s appeal to adaptors targeting young audiences lies in the specificities of his writing, that is, elements which are often referred to as ‘Dickensian’. This project draws on children’s literature criticism, adaptation theory, and Dickens scholarship. The first …
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Post-translational control of mitochondria by Fbxo7 in Parkinson's disease
… addition, I validated the mitochondrial fission adaptors MiD49 and MiD51 as novel binding partners of Fbxo7. MiD49 and MiD51 protein levels were found to be stabilised in the presence of Fbxo7, independently of Fbxo7’s activity as part of an SCF ligase complex. MiD49 and MiD51 were also found to …
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Origins and composition of the cullin-RING E3 ligases in trypanosomes
… multi-subunit complexes that comprise substrate adaptors, RINGs for the transference of ubiquitin and cullins that serve as scaffold for the complex.<br/><br/>Some cullin-RING E3 ligases and other elements of the ubiquitylation network have been described as resistance-associated genes in …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… of RNA viruses and they signal through the adaptors TRIF (TLR3, 4), MyD88 (TLR4, 7/8, 9), and MAVS (RIG-I). The innate response serves to limit viral spread and to activate adaptive immune responses which eventually clear the infection. We dissected the contribution of TLR- and RLR- mediated …
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Structural characterization of a protein/RNA complex : human TAP/NXF1 protein/retroviral CTE RNA
… contact the cellular mRNA indirectly via protein adaptors such as REF/Aly. It can also mediate the nuclear export of exogenous and partially processed viral mRNAs containing a cis-acting Constitutive Transport Element (CTE), which is the case for some types of simian retroviruses. The CTE RNA …
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Biomechanics and dynamics of turning
… mechanical performance of prosthetic rotation adaptors to data on ankle rotation in intact humans. We find that the human ankle varies in composite stiffness throughout the stride. While none of the rotation adaptors tested varies its stiffness in the same pattern, most of them encompassed the …
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Understanding and harnessing energy-dependent proteolysis for controlled protein degradation in bacteria
… with the aid of dedicated specificity factors (adaptors). The prior identification and detailed biochemical characterization of an efficient ClpXP degron (the ssrA tag) and cognate adaptor (SspB) serve as powerful tools and enable the mechanistic studies presented here. In Chapter 2, I describe …
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Importing French Drama for the American Stage: Giraudoux, Anouilh, Sartre, and Genet
… than French love of language). Consequently, as adaptors and translators worked with the dramatic texts of Giraudoux, Anouilh, Sartre, and Genet, they often chose to modify the tone of the plays, the specific details and historical contexts, and the patterns of the language.
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TYA Adaptations for the Theatre Educator
… methods from some of the best playwrights and adaptors in the TYA world, theatre educators will be able to create meaningful, challenging works adapted from children’s literature.</p>
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Messenger Ribonucleoprotein (Mrnp) Complexes: Proteomic and Functional Analysis
… but also look at the roles of conventional adaptors for the respective motors. Interestingly, both opposite-polarity motors, kinesin-1 and cytoplasmic dynein, are required for dFMRP-RNP transport, implying a coordination model rather than tug-of-war model for motor activities. Furthermore, …
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Mechanisms of dynein-based mRNA transport processes in human cells
… was first employed to identify candidate adaptors between dynein and mRNA in HeLa cells. Analysis of the interactomes of dynein and its co-factor BICD2 revealed that the RNA binding proteins FXR1 and FXR2 associate with the transport machinery independently of RNA, and that they link …
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Investigating the trafficking of Golgi-resident glycosylation enzymes
… Similar binding studies revealed that the COPI adaptors GOLPH3+3L pulled down the COPI coat and over a hundred novel clients. GOLPH3+3L were shown to interact promiscuously with the cytoplasmic tails of clients with a total predicted charge of ≥4+. An in vivo Golgi retention assay revealed that …
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