Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 144 for “"Adaptor protein"”.
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The characterization of adaptor protein homologues in Plasmodium falciparum
… in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The …
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Investigating the Role of Adaptor Protein ShcD in the Oligodendrocyte Lineage
… for the coordination of neuronal signaling. Adaptor protein ShcD is highly expressed in oligodendrocyte progenitor cells (OPCs), with a gradual reduction across differentiation to mature OLs. Utilizing ShcD wildtype (WT) and ShcD knockout (KO) mice, we investigated the role of ShcD within …
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The role of adaptor protein Mal/TIRAP in transducing TLR signalling
… developing targeted therapies. Mal/TIRAP is an adaptor protein and the first intracellular component of the TLR4 and TLR2 signalling pathways. In the traditional model of signalling, ligand stimulation dimerises TLR4 and TLR2 which then recruits Mal/TIRAP. Mal/TIRAP links the TLRS to the …
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Interaction between the AAA+ protease CIpXP and the adaptor protein SspB
… processes including regulatory pathways and protein quality control in prokaryotes and eukaryotes. ATP-dependent protein degradation is mediated by multimeric protease complexes, each consisting of a AAA+ ATPase and a peptidase component. Substrate selection by the proteases is a highly …
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Role of the adaptor protein, beta-arrestin1, in the Notch signaling pathway
… homologues of Kurtz and functions as an adaptor protein in a variety of cellular processes such as endocytosis, ubiquitination and nuclear shuttling. We hypothesize that a similar interaction occurs in mammalian cells between Notch, beta-arrestin1 and Deltex to negatively modulate the …
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An investigation of the function of adaptor protein complex 4 (AP-4)
… organelles. During vesicle trafficking, proteins are selectively sorted into membrane bound transport intermediates by vesicle adaptors, which include those of the highly conserved adaptor protein (AP) complex family. Each AP complex has a distinct subcellular localisation and functions …
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Structural and functional characterisation of pUL21, an α-herpesvirus phosphatase adaptor protein
… Virus infection is a complex process where viral proteins cooperate to exploit host cell metabolism while evading immune responses. Herpes simplex virus 1 (HSV-1) is a very prevalent human herpesvirus that causes life-long infection and is known to dramatically remodel the cellular environment …
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Structural and Functional Basis for the Autoregulation of the Adaptor Protein TOM1
Target of Myb 1 (TOM1) is an endosomal adaptor protein that plays a role in cargo membrane trafficking for degradation by serving as an alternative endosomal sorting complex required for transport component. TOM1 has also been shown to serve as a novel phosphatidylinositol 5-phosphate (PtdIns5P) …
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The Role of Adaptor Protein Grb2 in Ecotropic Retrovirus Entry and Receptor Trafficking
… we identified growth factor receptor-bound protein 2 (Grb2), as a key protein for eMLV infection. Grb2 is an adaptor that has been shown to couple cell surface receptors such as the epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (Met) to intracellular signaling …
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Role of the MecA adaptor protein in regulation of the AAA + chaperone ClpC of Bacillus subtilis
ClpC, a member of the AAA+ protein superfamily from Bacillus subtilis, is forming with ClpP a proteolytic system, that is part of the protein quality control system and involved in general proteolysis of misfolded and aggregated proteins. In addition ClpCP together with the adaptor MecA is …
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Biochemical and genetic analysis of the adaptor protein SH3P7 : insights from a newly generated knockout mouse
… is a widely expressed actin-binding adaptor protein identified as a substrate for protein tyrosine kinase (PTK) after BCR activation. In addition to two protein-binding modules specific for filamentous actin, SH3P7 also contains an SH3 domain. The biochemical studies presented here, …
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The N-end rule degradation pathway : substrate recognition and staged delivery to the CIpAP protease by the CIpS adaptor protein
Regulated protein degradation is crucial in the regulation of many physiological processes as well as in protein quality control. In all organisms, ranging from bacteria to mammals, ATP-dependent proteases carry out regulated protein degradation in order to maintain homeostasis as well as to …
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The Association of Single Nucleotide Polymorphisms (SNPs) in the Nitric Oxide Synthase 1 Adaptor Protein Gene (NOS1AP) and the QT Interval Duration Across Race/Ethnicity in Adults Without Clinical Cardiovascular Disease
Introduction: The QT interval is an independent risk factor for sudden cardiac death (SCD). A genome wide association study (GWAS) identified NOS1AP variants associated with QT, which has been replicated in predominantly Caucasian populations. The MESA study provides an opportunity to study single …
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Structural characterization of interaction of K11 and K63 mixed-linkage polyubiquitin chains with the tUIMs of epsin1
… of ubiquitin (Ub) to a variety of substrate proteins in cells is a versatile post-translational modification involved in the regulation of numerous cellular processes. The distinct messages that polyubiquitylation encodes are attributed to the multitude of conformations possible through …
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Unraveling the Dynamics of Ser126 Phosphorylation in Paxillin: A Focus on Phosphatase Activity
Paxillin is a focal adhesion adaptor protein essential for cell adhesion and migration, regulated by reversible phosphorylation. In endothelial cells, phosphorylation at serine 126 (Ser126) plays a key role in processes like angiogenesis and vascular permeability. This study aimed to identify the …
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The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa
Monogenic defects in the low density lipoprotein (LDL) uptake pathway occur commonly in South Africans, particularly in the Afrikaner community where inheritance is typically autosomal dominant, arising predominantly from abnormal structure and thus function of the LDL receptor (LDLr). Defects in …
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Exploring the Biophysical Properties of Domains Within Multi-Domain Proteins
… in understanding the biophysical properties of proteins using small modular domains such as SH3 domains. However, there is a surprising lack of knowledge regarding how these properties are affected when the domain is placed back within its full-length multi-domain protein. Using a combination of …
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ANALYSIS OF AXONAL TRANSPORT DEFECTS IN A ZEBRAFISH MODEL FOR SPINAL MUSCULAR ATROPHY
… a deficiency of the survival motor neuron (SMN) protein. It is characterised by the progressive loss of α-motor neurons (MNs), leading to muscle weakness, atrophy, and in the worst cases death. SMN is a ubiquitously expressed protein that is involved in spliceosome assembly. A decrease in SMN …
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