Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Adaptor complex"”.
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Characterization of the ADA/GCN5 transcriptional adaptor complex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Genetic and biochemical characterization of the ADAs, a transcriptional adaptor complex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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σ1-adaptin - the Small Subunit of the Clathrin Adaptor Complex AP-1
Der Adaptorkomplex AP-1 ist ein heterotetramerer Proteinkomplex, der an der Bildung von Clathrin-Vesikeln am trans-Golgi Netzwerk und an Endosomen mitwirkt. Durch die Bindung an Phosphatidylinositol-4-phosphat, an ARF-1 und an Sortierungssignale der transportierten Proteine gelangt der Komplex an …
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Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
Apicomplexan parasites use Ca²⁺-regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. Ca²⁺-dependent protein kinases (CDPKs) are required for microneme exocytosis; however, the molecular events that regulate trafficking and fusion of micronemes …
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Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
… Ende durch den heterotetrameren Clathrin-Adaptor AP-2 oder andere monomere Adaptoren.In dieser Arbeit zeigen wir, daß die mittlere Untereinheit µ2 des AP-2 Komplexes direkt mit dem zytoplasmatischen Schwanz der exzitatorischen AMPA-Rezeptor Untereinheit GluR2 über ein dibasisches Motiv …
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Characterization of the Human Adenovirus 19a E3/49K Protein
… motif in the cytoplasmic tail with the clathrin adaptor complex AP-2. From early endosomes 49K proteins and C-terminal fragments recycle to the TGN potentially involving the interaction of the cytoplasmic tail of 49K with the clathrin adaptor complex AP-1 or to the cell surface, whereas a …
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A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
… and was shown to mediate the binding of the AP-3 adaptor complex to the M5 i3. Immunocytochemical and live cell imaging of primary rat hippocampal neurons revealed co-localization of M5 and AGAP1- or AP-3- positive vesicles after treatment with a muscarinic agonist. Activity-induced receptor …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… of the AMPAR GluR2 subunit with the AP2 clathrin adaptor complex. We find that G2CT expression interferes with NMDAR-dependent AMPAR endocytosis and LTD, without affecting baseline synaptic transmission. When expressed in vivo, G2CT completely blocks the MD-induced depression of deprived-eye …
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Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum
… accessory proteins, one of which is the adaptor complex AP-2, to co-ordinate vesicle formation. Disruption of genes involved in clathrin-mediated endocytosis causes embryonic lethality in multicellular animals suggesting that clathrin-mediated endocytosis is a fundamental cellular …
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Investigations of the assembly and function of the Toxoplasma micropore
*Toxoplasma gondii* is an apicomplexan parasite that can invade all warm-blooded animals. One of the characteristic features of this parasite is its pellicle, a complex three-layer membrane that includes flattened vesicles that run the entire parasite. *Toxoplasma*’s pellicle has conferred the …
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Characterisation of the AP-3 adaptor-like complex
… coat consists of two components, clathrin and adaptor (or AP) complexes, the AP-1 complex is associated with the clathrin coated vesicles that bud from the TGN and the AP-2 complex is associated with the clathrin coated vesicles that bud from the plasma membrane. A new type of adaptor-like …