Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Adaptive resistance"”.
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Role of Macrophages In Adaptive Resistance to Anti-Vegf Therapy
… pathway in cancer has been limited by acquired resistance; yet, the mechanisms by which this occurs is unclear. We investigated the role of macrophages in the development of acquired resistance to anti-VEGF antibody (AVA) therapy.</p> <p>Materials and Methods: We first established a murine …
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Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… with anti-VEGF antibody (AVA) therapy, adaptive resistance is nearly ubiquitous and additional therapeutic options are limited. A dependence on glutamine metabolism, <em>via </em>the enzyme glutaminase (GLS), is a known mechanism of adaptive resistance.</p> <p><strong>Purpose: …
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A Temporal Fuzzy-ART Neural Network Architecture as a Model of Phoneme Perception
This paper explores the applicability of Adaptive Resistance Theory- (ART-) type neural networks for finding and encoding linguistic structures, specifically those corresponding to acoustic patterns in natural speech. We build an interpretation of human perceptual response to acoustic pattern in …
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Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
… heterogeneity and frequently (46%) develops resistance to neoadjuvant chemotherapy (NAC). Currently, the genomic basis of chemoresistance remains poorly understood. An important question is whether resistance to chemotherapy is driven by the selection of rare pre-existing subclones with …
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Measuring Single Cell Responses to Lapatinib In A Heterogeneous Population
… challenge with targeted therapy is the acquired resistance in the cancer cells to these therapies, quite often very rapidly in the course of a few months. One of the major targets in cancer has been the EGFR/ErbB2 network in breast and other cancer types. Prior work from our lab and others have …
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Does the human skin microbiome adapt to antibiotic exposure?
… colony and cell morphology, cross-resistance (to other antibiotics), growth rate and competitive fitness ability. S. epidermidis parent strains were firstly susceptible to antibiotics such as erythromycin and doxycycline, and later formed adaptive resistance. Erythromycin adapted …
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Factors that enhance the ability of Pseudomonas aeruginosa to resist the action of antibiotics
… treatment, focusing especially on the adaptive resistance could be the key area that the bacterium develops in this phenomenon. Most studies on antibiotic resistance in P.aeruginosa have focused upon genotypic studies. This study set out to develop an in vitro model to examine the …
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Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
… as well as lend direct insights into potential adaptive resistance mechanisms. However, quantification of phosphoproteome, especially the translationally relevant low abundant signals including tyrosine and pathway specific phosphorylation, is limited in the clinic. Here, we describe mass …
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China Dispossession Watch: Making Visible the Human Costs of Forced Land Expropriation in Urbanizing China
… communities navigate severe constraints through adaptive resistance strategies to overcome power asymmetries and institutional manipulation, and documents their economic, social, and health outcomes. Moving beyond analysis to practice, the thesis introduces two pragmatic interventions developed …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… rate to BRAF inhibitor treatment. In this study, adaptive resistance, and a potential combination of standard therapies in BRAF<sup>V600E</sup> CRC were unveiled. Intriguingly, a robust association of BRAF<sup>V600E</sup> mutation and DNA hypermethylation suggests this is a unique subgroup …
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Chemical penetration enhancers and in situ-forming reservoirs for trans-tympanic drug delivery : progress toward improved treatment of Otitis media
… a driving force behind the observed increase in adaptive resistance among pathogenic bacteria in the nasopharynx. Local, sustained delivery of antimicrobial agents to the site of infection allows for higher drug concentrations and optimized release profiles than are permitted by systemic …
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Leveraging Single Cell Technologies For The Characterization and Treatment of Refractory Pancreatic Cancer
… methods to a panel of PDO samples to explore adaptive resistance mechanisms of PDAC lesions following administration of epigenetically-modifying therapeutic agents (HDAC inhibitors). I describe a novel HDACi resistance mechanism of AP1 activation, which can be intercepted by using an AP1 …
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… the clinic. However, treatment-associated resistance mechanisms have long threatened to attenuate clinical benefit through either adaptive or acquired resistance. To better understand the impact of this mutation on this patient population, this dissertation has sought to characterize the …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… receptor (IGF1R), potentially as a mechanism of adaptive resistance. Combined inhibition of PI3K, mTOR, and IGF1R via small molecule inhibitors resulted in a drastically reduced tumor volume <em>in vivo</em>, despite the lack of substantial antiproliferative effects <em>in vitro</em>. …
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… (PDAC) to examine the tumor response to and adaptive resistance mechanisms engaged by therapy with two established methods of hypoxia-reducing therapy: the hypoxia-activated prodrug TH-302 and vascular endothelial growth factor receptor 2 (VEGFR-2) blockade. The combination of both modalities …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
… studies indicate that inhibiting MSMP in adaptive-resistant ovarian tumors combined with anti-angiogenic therapy can overcome adaptive resistance to anti-VEGF antibody-based therapy. Due to the high specificity of their targets and safety profiles, antibodies are a proven and fast-growing …
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Studies on the mechanism of zinc pyrithione resistance in Pseudomonas aeruginosa PAO1
… to passage <i>Pseudomonas aeruginosa</i> towards resistance against selected antimicrobial agents (Isothiazolone biocides). These passages in sub-minimal inhibitory concentrations (sub-MIC) of antimicrobial agents also exhibited corresponding shifts in outer membrane protein profiles. The aim of …
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Bioimage informatics for understanding the effects of chemotherapy on cellular signaling, structure, and function
… with cancer relapse, metastasis, and drug resistance. The biological mechanisms that drive the structural and functional changes in cancer cells associated with these features of disease progression remain poorly understood. Consequently, quantitative characterization of molecular signaling …
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… - regrowth of the bacterial cultures due to adaptive resistance development. Stochastic interaction surface analysis demonstrated the pronounced antagonism between meropenem and linezolid to be robust against variation in the growth phase and pharmacodynamic endpoint definition, but sensitive …
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Investigating the requirement of KRAS for the maintenance of pancreatic cancer
… KRAS for PDAC maintenance and potential resistance mechanisms that may arise in response to KRAS inhibition. Since there is no effective pharmacological KRAS inhibitor to date, we interrogated the requirement of KRAS for PDAC cell survival using an inducible shRNA-based system that …
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