Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"Adaptive evolution"”.
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Niche-adaptive evolution in Campylobacter jejuni
Campylobacter jejuni is the leading causative agent of human bacterial gastroenteritis. Human C. jejuni infection (campylobacteriosis) is frequently associated with poultry; through consumption of undercooked products, cross contamination from raw meats, or through direct contact with birds or …
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Isolation of low ethanol producing yeast strains using adaptive evolution
… of a non-genetic engineering approach, adaptive evolution, to generate variants of Saccharomyces cerevisiae that produce reduced levels of ethanol relative to the strains they were derived from. Sub-lethal concentrations of sulfite, which sequesters acetaldehyde, thereby limiting ethanol …
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Testing for host adaptive evolution using the maize streak virus model
… promote viral diversity and result in the rapid evolution of new, fitter MSV variants, continuous genomic surveillance of MSV is therefore important. Based on analyses of full genome sequences, MSV-A has been classified into five subtypes (-A1, -A2, -A3, -A4, and -A6) and more than 20 recombinant …
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Self-adaptive evolution of model structures and parameters / by Jason John Bobbin.
This thesis proposes a new self-adaptive, symbiotic model evolution framework SASME. SASME is described generally and then applied to the specific task of evolving rule sets with explicit default hierarchies for learning problems. Experiments are conducted on the SASME framework to establish the …
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Testing models of the adaptive evolution of consistent individual differences in behavior using sticklebacks
… in behavior is a recent challenge for evolutionary biology in general and behavioral ecology in particular. While there is some evidence that this limited behavioral plasticity may be a result of physiological or genetic constraints, there is growing theoretical evidence suggesting that …
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Invasion genomics, adaptive evolution, and transcriptional plasticity of Anopheles stephensi in Ethiopia and Yemen : implications for malaria transmission and control.
… and Plasmodium falciparum, highlighting evolutionary feedbacks within the transmission system. High-resolution whole-genome sequencing resolves population structure, connectivity, and recent demographic history, and identifies loci under positive selection associated with insecticide …
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Adaptive evolution, sex-linkage, and gene conversion in the voltage-gated sodium channels of toxic newts and their snake predators
… exceptions exist. These include the convergent evolution of tetrodotoxin resistance in snakes, which has a simple genetic basis and can be used as a model system to investigate the genetic basis of adaptive evolution. Tetrodotoxin is a potent neurotoxin used as a chemical defense by various …
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Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
… comprises three chapters exploring the adaptive evolution of surface proteins in pathogens responsible for Lyme Disease and Acquired Immunodeficiency Syndrome (AIDS). The first chapter focused on antigenicity analysis of the VlsE protein in <em>Borreliella</em> bacteria. Conserved …
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Embryology and the evolutionary synthesis: Waddington, development and genetics
… and morphology within mid twentieth century evolution theory, is discussed in the context of the growth to dominance of natural selection as the orthodox mechanism of adaptive evolution. The unification of neo-Mendelian heredity and neo-Darwinian selection theory, is descnbed as the core of …
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Evolutionary dynamics of the human gut microbiome
… members in the ecosystem. Understanding the evolutionary dynamics of microbial species in the gut microbiome requires sequencing information that differentiates strains and even single cells. In this thesis, I present efforts that investigate the evolution of bacterial strains in their …
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Evolutionary design of digital trajectory-tracking controllers for robotic manipulators
… in this thesis. In particular, the following evolutionary optimisation techniques are used to design digital trajectorytracking controllers for robotic manipulators:(i) genetic algorithms,(ii) non-adaptive evolution strategies(iii) adaptive evolution strategies.It is shown that, with …
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Adaptation in a Changing World: Evolutionary mechanisms of salt tolerance in a coastal amphibian
In order to predict evolutionary outcomes of environmental change on populations in nature, we need an improved understanding of the biological mechanisms that affect whether organisms will adapt to a changed environment. This dissertation capitalizes on the unlikely discovery of a freshwater …
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Identifying genes that confer ethanol tolerance in Saccharomyces cerevisiae
… (SM) and a chemical (CM) mutant from W303, via adaptive evolution (Stanley 2008). Transcriptome analysis of the resultant ET mutants found that expression levels of hundreds of genes were altered, relative to the parent under ethanol-stress conditions. The primary objective of this thesis was to …
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The Distribution of Fitness Effects of Synonymous Mutations in a Gene under Selection
Models of adaptive evolution consider the path that a population takes to a fitness optimum through a series of beneficial single-nucleotide changes, although synonymous mutations, which do not alter the amino acid sequence, have been conventionally seen as ‘silent’ changes. However, recent studies …
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Platyrrhine Phylogenetics With A Focus On Callitrichine Life History Adaptations
… was accessed though detection of chimerism and adaptive evolution of genes involved in reproduction. We determined based on these analysis that the reduction in litter size is likely pre-ovulation and due to a reversion to mono-ovulation in the species.</p>
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Systematic and combinatorial approaches for metabolic engineering of optimal yeast strains to produce fuels and chemicals
… demonstrates a promising approach for directing adaptive evolution toward fermentative metabolism. To understand the genetic basis of the improved phenotype, genome sequencing was conducted and used to identify a loss of function mutation in a repressor of galactose metabolic genes (Gal80p); this …
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Insight Into Human Brain Evolution Through Phylogenetic Analysis And Comparative Genomics
… and molecular approach to study human brain evolution. First, we traced the evolutionary history of encephalization across mammals through a phylogenetic analysis in order to infer at which point significant changes in brain size occurred. We demonstrate that variation in brain size began in …
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Molecular Evolution of Anthocyanin Biosynthesis in Morning Glories
… of adaptation has become a central focus of evolutionary biology, and the incorporation of increasingly sophisticated analytical tools from molecular biology has made identifying causal genes a practical reality. The work presented herein addresses the effects of pleiotropic constraint on …
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Identifying ecological differentiation in microbial communities across taxonomic scales
… both genetic and phenotypic, is a product of evolutionary and ecological processes interacting at multiple levels of biological organization. High-throughput sequencing is providing a means to resolve the vast amount of genetic diversity in microbial assemblages. However, a current fundamental …
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Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity
… thesis is to investigate aspects of molecular evolution and enzyme engineering using the experimental evolution of Tobacco Etch Virus cysteine protease (TEV) as a model. I map key features of the local fitness landscape and characterise how they affect details of enzyme evolution. In order to …
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