Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 53 for “"Adaptive changes"”.
-
Identifying and Targeting Adaptive Changes to Bet Inhibition In Ovarian Cancer
… of the mTOR pathway appeared to be an early adaptive response to BET inhibition. Decreased cell viability and increased apoptosis were seen with the addition of an mTORC1 or dual mTORC1/2 inhibitor to CN210 compared with CN210 alone. Notably, we found that decreased Akt activation and …
-
Studies on the mechanisms underlying adaptive changes of fatty acid synthetase in rat liver
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Adaptive changes in the morphology of natural materials due to alterations in mechanical stress
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1997.
-
The role of pituitary growth hormone in the regulation of albumin synthesis and catabolism
… had centred mainly upon the nature of the adaptive changes occurring in albumin metabolism in response to altered dietary protein intake, and by the time I was due to take up my appointment many of these adaptive changes had been clearly defined. The factors mediating these changes however …
-
The role of pituitary growth hormone in the regulation of albumin synthesis and catabolism
… had centred mainly upon the nature of the adaptive changes occurring in albumin metabolism in response to altered dietary protein intake, and by the time I was due to take up my appointment many of these adaptive changes had been clearly defined. The factors mediating these changes however …
-
AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… systemic physiological, metabolic, and vascular changes in order to maintain cellular homeostasis. Using C57BL/6J mice exposed to normoxia, hypoxia or hyperoxia, we studied the systemic physiological and brain microvascular adaptive changes in response to fluctuations in atmospheric oxygen level. …
-
Alleviating Equines: Investigating the Hypothesized Mechanisms of Change in Equine Assisted Psychotherapy
… with therapy horses is responsible for producing changes in general psychological constructs (secondary level). Adaptive changes in secondary level constructs account for reductions in mental illness symptoms (tertiary level). Results indicated a significant reduction in tertiary level symptoms, …
-
Motion Processing in Direction Selective Retinal Ganglion Cells through Dynamic Environments
… contrasts, and how populations of DSGCs adapt to changes in light level, spanning moonlight to daylight. In Chapter 2, I describe the development of a functional classification method to identify and classify DSGCs. In Chapter 3, I show how NMDA-dependent synapses improve direction coding in DSGCs …
-
Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading of bones in vivo include bone formation, though it is unclear if this …
-
The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase
… investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic acid decreased …
-
Comparative Genomics Insights into Speciation and Evolution of Hawaiian Drosophila
… provides a natural arena for understanding adaptive radiation and speciation, and genomics and bioinformatics offer new approaches for studying these fundamental processes. The mode of speciation should have profound impacts on the genomic architecture and patterns of reproductive isolation …
-
Fasten-induzierte Regulation hepatischer basolateraler Gallensäuretransporter in Ratten vermittelt über PGC-1[alpha]/HNF-4[alpha]
Fasting induces numerous adaptive changes in metabolism by several central signaling pathways, the most important represented by the HNF4-alpha PGC-1-alpha-pathway. Because HNF4-alpha has been identified as central regulator of basolateral bile acid transporters and a previous study reports …
-
Post occupancy evaluation of five story walk up dwellings : the case of four mass housing estates in Algiers.
… features of their housing environment. Adaptive changes made to the original design of the dwellings have been recorded, as well as the space use patterns of the main living areas. The relationship between residents' satisfaction with their dwelling and their perception of the various …
-
Neuronaalisten kolinergisten nikotiinireseptorien positiivinen ja negatiivinen allosteerinen modulaatio
… drugs such as nicotine and opioids cause adaptive changes in central nervous system. In addition to binding site of acetylcholine, various allosteric binding sites have been identified in nAChRs. Allosteric ligands are able to modulate the effect of agonist by binding to allosteric binding …
-
Novel Bifunctional Ligands For Neuropathic Pain: Design and Synthesis of Overlapping Pharmacophores of Opioid and Melanocortin Ligands
Biologically many disease states lead to changes in expressed proteins. Therefore, "system changes" that occur must be considered in any treatment for the disease. This new approach to drug design and discovery would be particularly applicable to the diseases that involve adaptive changes in the …
-
The metabolic sequelae of oesophago-gastric resection
… has long been recognised to result in profound changes in the handling of ingested nutrients. This results in significant morbidity after radical surgery for oesophago-gastric cancer, in particular post-prandial hypoglycaemia, altered appetite, early satiety and noxious post-prandial symptoms. …
-
Organisational sensemaking through the sustainable management of Fujian opera troupes in the urban-rural reconstruction
… the Fujian Opera Troupe is experiencing profound changes in the external environment and internal management. This thesis investigates organisational sensemaking in the sustainable management of Fujian Opera Troupes from pluralistic stakeholders based on the theoretical framework in applied …
-
Identification of host cellular factors that regulate human norovirus replication
… human norovirus replication, and to analyse the adaptive changes required to support its long-term replication in cell culture. First, using a genome-wide microarray screen, we found that the expression of the receptor for type III interferons is suppressed by epigenetic modification of its …
-
Correlated evolution in experimental populations of yeast
… effects were not correlated, such that adaptive changes of large effect tended to have disproportionately small correlated effects and (3) reciprocal correlated responses to selection did not evolve to symmetry. The view of adaptation emerging from this work is that correlated effects …
Page 1 of 3